Abstract
The design of cytocompatible polymer materials without any cytotoxicity is an essential and important part in the preparation of nanodevices for the delivery of bioactive molecules. The phospholipid polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) is a strong candidate to provide such nanodevices because of its excellent cytocompatibility. Water-soluble MPC polymers bearing hydrophobic monomer units can form a stable polymer aggregate structure in biological milieus because of their amphiphilic nature. The obtained polymer aggregate can solubilize poorly soluble molecules, including bioactive molecules. In addition, MPC polymers containing active ester units to immobilize bioactive molecules are useful to investigate the bioactivity of immobilized molecules because non-specific interactions with biomolecules are reduced. The concept of a “cell-shuttle” that can penetrate the cell membrane without showing any cytotoxicity will be described.
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Abbreviations
- MPC:
-
2-Methacryloyloxyethyl phosphorylcholine
- BMA:
-
n-Butyl methacrylate
- MEONP:
-
p-Nitrophenyloxycarbonyl poly(oxyethylene) methacrylate
- PLA:
-
Poly(L-lactic acid)
- R8:
-
Octaarginine peptide
- PTX:
-
Paclitaxel
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Konno, T. (2014). Cytocompatible Phospholipid Polymers for Non-invasive Nanodevices. In: Prokop, A., Iwasaki, Y., Harada, A. (eds) Intracellular Delivery II. Fundamental Biomedical Technologies, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8896-0_13
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DOI: https://doi.org/10.1007/978-94-017-8896-0_13
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