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Adipose-Derived Stem Cells as a Novel Tool for Future Regenerative Medicine

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Stem Cells and Cancer Stem Cells, Volume 12

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 12))

Abstract

Stem cell-based therapies for the repair and regeneration of damaged tissues and organs offer a paradigm shift that may provide alternative therapeutic solutions for a number of diseases. The use of either embryonic stem cells or induced pluripotent stem cells in clinical situations may be still limited due to cell behaviors, ethical considerations, and genetic manipulation, even though these cells are theoretically highly beneficial. Adipose-derived stem cells (ASCs) seem to be an ideal population of stem cells for practical regenerative medicine since they are plentiful, of autologous tissue origin and thus non-immunogenic, and are more available due to minimal ethical considerations. Furthermore, recent basic research and preclinical studies have revealed that the use of ASCs in regenerative medicine is not limited to mesodermal components, but extends to both ectodermal and endodermal tissues and organs, even though ASCs are mesodermal in origin. This chapter will describe the biology of ASCs and their proliferation and differentiation capacities, and will summarize the current preclinical and clinical data from a variety of medical fields on the use of ASCs in regenerative medicine.

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Author information

Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1138421, Japan

    Hiroshi Mizuno MD, PhD & Morikuni Tobita MD, PhD

  2. Department of Surgery, Surgical Bio-engineering Laboratory, University of California, Davis, 4625 2nd Avenue, Room 3001, Sacramento, CA, 95817, USA

    Hakan Orbay MD, PhD

  3. Department of Plastic and Reconstructive Surgery, Baskent University Faculty of Medicine, Fevzi Cakmak Cad. 5. Sok., No: 48, 06490, Bahcelievler, Ankara, Turkey

    A. Cagri Uysal MD, PhD

  4. Department of Plastic and Reconstructive Surgery, Nanfang Hospital of Southerm Medical University, Guangzhou Dadao Bei 1838, Baiyun District, Guangzhou, China

    Feng Lu MD, PhD

Authors
  1. Hiroshi Mizuno MD, PhD
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  2. Morikuni Tobita MD, PhD
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  3. Hakan Orbay MD, PhD
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  4. A. Cagri Uysal MD, PhD
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  5. Feng Lu MD, PhD
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Corresponding author

Correspondence to Hiroshi Mizuno MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Mizuno, H., Tobita, M., Orbay, H., Uysal, A.C., Lu, F. (2014). Adipose-Derived Stem Cells as a Novel Tool for Future Regenerative Medicine. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 12. Stem Cells and Cancer Stem Cells, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8032-2_15

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