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Genetics and Epigenetic Regulation in Allergic Diseases

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Allergy Bioinformatics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 8))

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Abstract

Multiple mechanisms mediate the risk of allergic diseases, including altered innate and adaptive immune responses, gene-environment interactions, epigenetic regulation, and possibly gene-environment-epigene interactions. The gene-environment interaction adds to the complexity of allergy and asthma and is now being successfully explored using epigenetic approaches. Allergic diseases are inheritable, influenced by the environment, and modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Environmental exposures, including prenatal maternal smoking, have been associated with allergy-related outcomes that could be explained by epigenetic regulation. In addition, several allergy- and asthma-related genes have been found to be susceptible to epigenetic regulation, including genes important to T effector pathways (IFN-γ, IL-4, IL-13, IL-17) and T-regulatory pathways (FoxP3). Therefore, investigation into the relationship between epigenetic regulation and allergic disease is critical for understanding the development of allergy and asthma. Previously published experimental work, with few exceptions, has been comprised mostly of small observational studies and models in in vitro systems and animals. Recently, however, and due to new and advanced technologies, novel translational research and exciting and elegant experimental studies have been published. Epigenetic factors (DNA methylation, modifications of histone tails or noncoding RNAs) work with other components of the cellular regulatory machinery to control the levels of expressed genes. Technologies to investigate epigenetic factors on a genomic scale and comprehensive approaches to data analysis have recently emerged and continue to improve. This chapter addresses the fundamental questions of how genetics and epigenetics influence allergic diseases, including asthma. These include how anti-asthmatic agents can induce epigenetic changes, and how epigenetic regulation can influence cytokine and chemokine production in immune cells. The discovery and validation that genetic and epigenetic biomarkers may be linked to exposure, allergies, or both might lead to better genotyping and epigenotyping of the risk, prognosis, treatment prediction, and development of novel therapies for the treatment of allergy.

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References

  • Alati R, Al Mamun A, O’Callaghan M, Najman JM, Williams GM. In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology. 2006;17(2):138–44.

    Article  PubMed  Google Scholar 

  • Andiappan AK, de Wang Y, Anantharaman R, Parate PN, Suri BK, Low HQ, Li Y, Zhao W, Castagnoli P, Liu J, et al. Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. PLoS ONE. 2011;6(5):e19719.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Birben E, Sahiner UM, Karaaslan C, Yavuz TS, Cosgun E, Kalayci O, Sackesen C. The genetic variants of thymic stromal lymphopoietin protein in children with asthma and allergic rhinitis. Int Arch Allergy Immunol. 2014;163(3):185–92.

    Article  CAS  PubMed  Google Scholar 

  • Black S, Teixeira AS, Loh AX, Vinall L, Holloway JW, Hardy R, Swallow DM. Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort. Allergy. 2009;64(8):1172–8.

    Article  CAS  PubMed  Google Scholar 

  • Bonnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet. 2013;45(8):902–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bonnelykke K, Sleiman P, Nielsen K. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014a;46(1):51–5.

    Article  CAS  PubMed  Google Scholar 

  • Bonnelykke K, Sleiman P, Nielsen K, Kreiner-Moller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014b;46(1):51–5.

    Article  CAS  PubMed  Google Scholar 

  • Brinkman AB, Gu H, Bartels SJ, Zhang Y, Matarese F, Simmer F, Marks H, Bock C, Gnirke A, Meissner A, et al. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk. Genome Res. 2012;22(6):1128–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, et al. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics. 2014;7:48.

    Article  PubMed  PubMed Central  Google Scholar 

  • Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol. 2003;111(2):215–25 quiz 26.

    Article  CAS  PubMed  Google Scholar 

  • Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet. 2009;41(12):1350–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Duffy DL, Martin NG, Battistutta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis. 1990;142(6 Pt 1):1351–8.

    Article  CAS  PubMed  Google Scholar 

  • Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med. 2006;355(21):2226–35.

    Article  CAS  PubMed  Google Scholar 

  • Esteller M. Epigenetics in cancer. N Engl J Med. 2008;358(11):1148–59.

    Article  CAS  PubMed  Google Scholar 

  • Ferreira MA, Matheson MC, Tang CS, Granell R, Ang W, Hui J, Kiefer AK, Duffy DL, Baltic S, Danoy P, et al. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J Allergy Clin Immunol. 2014;133(6):1564–71.

    Article  CAS  PubMed  Google Scholar 

  • Fields PE, Kim ST, Flavell RA. Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol. 2002;169(2):647–50.

    Article  CAS  PubMed  Google Scholar 

  • Galanter J, Choudhry S, Eng C, Nazario S, Rodriguez-Santana JR, Casal J, Torres-Palacios A, Salas J, Chapela R, Watson HG, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med. 2008;177(11):1194–200.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Godfrey S. Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness. Am J Respir Crit Care Med. 2001;163(4):1030.

    Article  CAS  PubMed  Google Scholar 

  • Gustafsson DSO, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis–a prospective follow-up to 7 years of age. Allergy. 2000;55(5):240–5.

    Article  CAS  PubMed  Google Scholar 

  • Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, Johnson BE, Fouse SD, Delaney A, Zhao Y, et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010;28(10):1097–105.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hinds DA, McMahon G, Kiefer AK, Do CB, Eriksson N, Evans DM, St Pourcain B, Ring SM, Mountain JL, Francke U, et al. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat Genet. 2013;45(8):907–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, et al. Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J Allergy Clin Immunol. 2008;121(3):769–70.

    Article  CAS  PubMed  Google Scholar 

  • Ho SM. Environmental epigenetics of asthma: an update. J Allergy Clin Immunol. 2010;126(3):453–65.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai H-J, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, et al. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015; 6.

    Google Scholar 

  • Hung CH, Chu YT, Suen JL, Lee MS, Chang HW, Lo YC, Jong YJ. Regulation of cytokine expression in human plasmacytoid dendritic cells by prostaglandin I2 analogues. Eur Respir J. 2009;33(2):405–10.

    Article  CAS  PubMed  Google Scholar 

  • Hung CH, Yang SN, Kuo PL, Chu YT, Chang HW, Wei WJ, Huang SK, Jong YJ. Modulation of cytokine expression in human myeloid dendritic cells by environmental endocrine-disrupting chemicals involves epigenetic regulation. Environ Health Perspect. 2010;118(1):67–72.

    CAS  PubMed  Google Scholar 

  • Idzko M, Hammad H, van Nimwegen M, Kool M, Vos N, Hoogsteden HC, Lambrecht BN. Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J Clin Invest. 2007;117(2):464–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009;41(2):178–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature. 2010; 467(7313): 338–42.

    Google Scholar 

  • Jones B, Chen J. Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J. 2006;25(11):2443–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim WK, Kwon JW, Seo JH, Kim HY, Yu J, Kim BJ, Kim HB, Lee SY, Kim KW, Kang MJ, et al. Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children. J Allergy Clin Immunol. 2012; 130(2): 421–6.

    Google Scholar 

  • Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children. Clin Epigenetics. 2012;4(1):17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kuo CH, Ko YC, Yang SN, Chu YT, Wang WL, Huang SK, Chen HN, Wei WJ, Jong YJ, Hung CH. Effects of PGI2 analogues on Th1- and Th2-related chemokines in monocytes via epigenetic regulation. J Mol Med (Berl). 2011;89(1):29–41.

    Article  CAS  PubMed  Google Scholar 

  • Kuo CH, Lin CH, Yang SN, Huang MY, Chen HL, Kuo PL, Hsu YL, Huang SK, Jong YJ, Wei WJ, et al. Effect of prostaglandin I2 analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation. Mol Med. 2012;18:433–44.

    Article  CAS  PubMed  Google Scholar 

  • Kuo CH, Hsieh CC, Kuo HF, Huang MY, Yang SN, Chen LC, Huang SK, Hung CH. Phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation. Allergy. 2013;68(7):870–9.

    Article  CAS  PubMed  Google Scholar 

  • Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, Mullen Y, Pfeifer GP, Ferreri K. Insulin gene expression is regulated by DNA methylation. PLoS ONE. 2009;4(9):e6953.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity. 2002;16(5):649–60.

    Article  CAS  PubMed  Google Scholar 

  • Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol. 2010; 125(2):328–35.

    Google Scholar 

  • Li YF, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest. 2005;127(4):1232–41.

    PubMed  Google Scholar 

  • Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009;462(7271):315–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene. 2010;29(25):3650–64.

    Article  CAS  PubMed  Google Scholar 

  • Lu MP, Chen RX, Wang ML, Zhu XJ, Zhu LP, Yin M, Zhang ZD, Cheng L. Association study on IL4, IL13 and IL4RA polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population. PLoS ONE. 2011;6(11):e27363.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007;448(7152):470–3.

    Article  CAS  PubMed  Google Scholar 

  • Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nilsson D, Henmyr V, Hallden C, Sall T, Kull I, Wickman M, Melen E, Cardell LO. Replication of genomewide associations with allergic sensitization and allergic rhinitis. Allergy. 2014;69(11):1506–14.

    Article  CAS  PubMed  Google Scholar 

  • Ohno T, Morita H, Arae K, Matsumoto K, Nakae S. Interleukin-33 in allergy. Allergy. 2012;67(10):1203–14.

    Article  CAS  PubMed  Google Scholar 

  • Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441–6.

    Article  CAS  PubMed  Google Scholar 

  • Pankratz VS, Vierkant RA, O’Byrne MM, Ovsyannikova IG, Poland GA. Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment. BMC Immunol. 2010;11:48.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ramasamy ACI, Coin LJ, Kumar A, McArdle WL, Imboden M, Leynaert B, Kogevinas M, Schmid-Grendelmeier P, Pekkanen J, Wjst M, Bircher AJ, Sovio U, Rochat T, Hartikainen AL, Balding DJ, Jarvelin MR, Probst-Hensch N, Strachan DP, Jarvis DL. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol. 2011a;128:9.

    Article  Google Scholar 

  • Ramasamy A, Curjuric I, Coin LJ, Kumar A, McArdle WL, Imboden M, Leynaert B, Kogevinas M, Schmid-Grendelmeier P, Pekkanen J, et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol. 2011b;128(5):996–1005.

    Article  CAS  PubMed  Google Scholar 

  • Sakashita M, Yoshimoto T, Hirota T, Harada M, Okubo K, Osawa Y, Fujieda S, Nakamura Y, Yasuda K, Nakanishi K, et al. Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy. 2008;38(12):1875–81.

    Article  CAS  PubMed  Google Scholar 

  • Savenije OE, Mahachie John JM, Granell R, Kerkhof M, Dijk FN, de Jongste JC, Smit HA, Brunekreef B, Postma DS, Van Steen K, et al. Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. J Allergy Clin Immunol. 2014;134(1):170–7.

    Article  CAS  PubMed  Google Scholar 

  • Schoenborn JR, Dorschner MO, Sekimata M, Santer DM, Shnyreva M, Fitzpatrick DR, Stamatoyannopoulos JA, Wilson CB. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol. 2007;8(7):732–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Song CX, Clark TA, Lu XY, Kislyuk A, Dai Q, Turner SW, He C, Korlach J. Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine. Nat Methods. 2012;9(1):75–7.

    Article  CAS  Google Scholar 

  • Statham AL, Robinson MD, Song JZ, Coolen MW, Stirzaker C, Clark SJ. Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA. Genome Res. 2012;22(6):1120–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011a;43(9):887–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011b;43(9):887–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsay JJ, Tchou-Wong KM, Greenberg AK, Pass H, Rom WN. Aryl hydrocarbon receptor and lung cancer. Anticancer Res. 2013;33(4):1247–56.

    PubMed  PubMed Central  Google Scholar 

  • Tykocinski LO, Hajkova P, Chang HD, Stamm T, Sozeri O, Lohning M, Hu-Li J, Niesner U, Kreher S, Friedrich B, et al. A critical control element for interleukin-4 memory expression in T helper lymphocytes. J Biol Chem. 2005;280(31):28177–85.

    Article  CAS  PubMed  Google Scholar 

  • Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol. 2008;8(3):169–82.

    Article  CAS  PubMed  Google Scholar 

  • Verlaan DJ, Berlivet S, Hunninghake GM, Madore AM, Lariviere M, Moussette S, Grundberg E, Kwan T, Ouimet M, Ge B, et al. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet. 2009;85(3):377–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wan YI, Strachan DP, Evans DM, Henderson J, McKeever T, Holloway JW, Hall IP, Sayers I. A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom. J Allergy Clin Immunol. 2011; 127(1):223–31.

    Google Scholar 

  • Wan YI, Shrine NR, Soler Artigas M, Wain LV, Blakey JD, Moffatt MF, Bush A, Chung KF, Cookson WO, Strachan DP, et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax. 2012;67(9):762–8.

    Article  CAS  PubMed  Google Scholar 

  • Watson B, Gauvreau GM. Thymic stromal lymphopoietin: a central regulator of allergic asthma. Expert Opin Ther Targets. 2014;18(7):771–85.

    Article  CAS  PubMed  Google Scholar 

  • Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity. 2009;30(1):155–67.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wei X, Zhang Y, Fu Z, Zhang L. The association between polymorphisms in the MRPL4 and TNF-alpha genes and susceptibility to allergic rhinitis. PLoS ONE. 2013;8(3):e57981.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weissmann F, Lyko F. Cooperative interactions between epigenetic modifications and their function in the regulation of chromosome architecture. BioEssays. 2003;25(8):792–7.

    Article  CAS  PubMed  Google Scholar 

  • White GP, Watt PM, Holt BJ, Holt PG. Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. J Immunol. 2002;168(6):2820–7.

    Article  CAS  PubMed  Google Scholar 

  • Zemach A, McDaniel IE, Silva P, Zilberman D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. 2010;328(5980):916–9.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan, People’s Republic of China

    Chang-Hung Kuo

  2. Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, #100, Tz-You 1st Road, Kaohsiung, Taiwan, 807, People’s Republic of China

    Chang-Hung Kuo & Chih-Hsing Hung

  3. Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, People’s Republic of China

    Chih-Hsing Hung

  4. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, People’s Republic of China

    Chih-Hsing Hung

  5. Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, People’s Republic of China

    Chih-Hsing Hung

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  1. Chang-Hung Kuo
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Correspondence to Chih-Hsing Hung .

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  1. The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

    Ailin Tao

  2. Department of Medicine, University of CA, San Diego, La Jolla, California, USA

    Eyal Raz

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Kuo, CH., Hung, CH. (2015). Genetics and Epigenetic Regulation in Allergic Diseases. In: Tao, A., Raz, E. (eds) Allergy Bioinformatics. Translational Bioinformatics, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7444-4_4

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