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Cancer Stem Cell Dynamics and Regulation

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Stem Cells and Cancer Stem Cells, Volume 13

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 13))

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Abstract

Mathematical models provide many insights into both the biology of cancer and the optimization of its treatment. Cancer stem cells represent a novel target of cancer therapeutics. While cancer stem cells can represent a relatively small proportion of the total cells within a tumor, they are responsible for driving the dynamics of tumor growth and invasiveness. Modeling in combination with experimental validation has advanced quantitative understanding of cancer stem cells and their interaction with their microenvironment. We present here the salient features of a set of examples of mathematical models that have contributed to our current understanding of how cancer stem cells are regulated and describe further opportunities for modeling.

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Author information

Authors and Affiliations

  1. Division of Hematology-Oncology, University of California, Suite 2333, PVUB, 957059, Los Angeles, CA, 90095, USA

    Han S. Myat

  2. Department of Biomathematics, and Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA

    Mary E. Sehl

Authors
  1. Han S. Myat
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  2. Mary E. Sehl
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Corresponding author

Correspondence to Mary E. Sehl .

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Myat, H.S., Sehl, M.E. (2015). Cancer Stem Cell Dynamics and Regulation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 13. Stem Cells and Cancer Stem Cells, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7233-4_7

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