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Galectin-3 in Cardiovascular Disease

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General Methods in Biomarker Research and their Applications

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Abstract

Galectin-3 (Gal-3) is a member of the ß-galactoside binding protein family. It is discussed as a novel plasma biomarker secreted mainly by macrophages and different tissues like lung, ovary, breast and others. Gal-3 is probably not expressed in significant amounts in the myocardium. Recombinant mouse models are available. Gal-3 might be a drug target which is increased in the plasma in heart failure and kidney disease. In the experimental setting Gal-3 is associated with fibrosis development. High plasma Gal-3 concentrations were found to be associated with cardiovascular mortality in different studies. However, absolut plasma values differ considerably.

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Authors and Affiliations

  1. Clinical Sciences/Global Biomarker Strategy & Development, Bayer HealthCare AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Frank Kramer

  2. Herz- und Diabeszentrum NRW, Klinik für Thorax- und Kardiovaskularchirurgie, Erich und Hanna Klessmann-Institut für Kardiovaskuläre Forschung und Entwicklung, Universitätsklinikum der Ruhr-Universität Bochum, Georgstr. 1, 32545, Bad Oeynhausen, Germany

    Hendrik Milting

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Correspondence to Hendrik Milting .

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  1. Diabetes & Nutritional Sciences Division, King's College, London, United Kingdom

    Victor R. Preedy

  2. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

    Vinood B. Patel

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F.K. is a full-time employee of BAYER HealthCare AG, Germany.

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Kramer, F., Milting, H. (2014). Galectin-3 in Cardiovascular Disease. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7740-8_32-1

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