Abstract
Although readily available and convenient to use on PET/CT, SUV measurements are influenced by biologic and technologic factors like injected activity and scan duration. The aim of this study was to investigate the effect of varying scan duration on SUV using standard clinical activities of 18F-FDG. Patient PET/CT images were acquired in list-mode for 6 min in forty 18F-FDG oncology patients with known tumor. For each patient, data were sorted into 10 images of different durations (from 10 s to 6 min). SUVmax were measured for the lesions in the images. Tumor SUVmax were statistically analyzed taking the low-noise 6 min SUVmax as standard. For each of the nine scan duration from 10 s to 5 min, the normalized SUVmax were 1.080 ± 0.1611, 1.041 ± 0.1043, 1.005 ± 0.0732, 1.004 ± 0.0696, 1.005 ± 0.0456, 0.995 ± 0.0452, 0.996 ± 0.0299, 1.001 ± 0.0233, and 1.0002 ± 0.0144, respectively. One-sample t test revealed that the SUVmax biases for scan durations greater than 40 s were not statistically significant. It was concluded that scan duration as short as 40 s could be applied without compromising the quality of SUVmax measure.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Thie JA (2004) Understanding the standardized uptake value, its methods, and implications for usage. J Nucl Med 45(9):1431–1434
Adams MC, Turkington TG, Wilson JM et al (2010) A systematic review of the factors affecting accuracy of SUV measurements. Am J Roentgenol 195(2):310–320
Hu Z, Wang W, Gualtieri EE, et al (2007) An LOR-based systematic and fully-3D PET image reconstruction using a blob-basis function. In: IEEE nuclear science symposium conference record, 2007 (NSS’07), vol 6. pp. 4415–4418)
Borst GR, Belderbos JSA, Boellaard R et al (2005) Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer. Eur J Cancer 41:1533–1541
Wahl RL, Jacene H, Kasamon Y, et al (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 50(suppl):122S–150SS
Soret M, Bacharach SL, Buvat I (2007) Partial-volume effect in PET tumor imaging. J Nucl Med 48(6):932–945
Delbeke D, Coleman RE, Guiberteau MJ et al (2006) Procedure guideline for tumor imaging with 18F-FDG PET/CT 1.0. J Nucl Med 47(5):885–895
Barrington SF, Begent J, Lynch T et al (2008) Guidelines for the use of PET–CT in children. Nucl Med Commun 29(5):418–424
Boellaard R, O’Doherty M, Weber W et al (2010) FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0. Eur J Nucl Med Mol Imaging 37(1):181–200
Tatsumi M, Clark P, Nakamoto Y et al (2003) Impact of body habitus on quantitative and qualitative image quality in wholebody FDG-PET. Eur J Nucl Med Mol Imaging 30(1):40–45
Halpern B, Dahlbom M, Quon A et al (2004) Impact of patient weight and emission scan duration on PET/CT image quality and lesion detectability. J Nucl Med 45(5):797–801
Watson C, Casey M, Bendriem B et al (2005) Optimizing injected dose in clinical PET by accurately modeling the counting-rate response functions specific to individual patient scans. J Nucl Med 46(11):1825–1834
Goethals I, D’Asseler Y, Dobbeleir A et al (2010) The effect of acquisition time on visual and semi-quantitative analysis of F-18 FDG-PET studies in patients with head and neck cancer. Nucl Med Commun 31(3):227–231
Lodge MA, Chaudhry MA, Wahl RL (2012) Noise considerations for PET quantification using maximum and peak standardized uptake value. J Nucl Med 53(7):1041–1047
Brambilla M, Matheoud R, Secco C et al (2007) Impact of target-to-background ratio, target size, emission scan duration, and activity on physical figures of merit for a 3D LSO-based whole body PET/CT scanner. Med Phys 34(10):3854–3865
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Fan, Q., Su, M., Zhou, L. (2014). Impact of Scan Duration on PET/CT Maximum Standardized Uptake Value Measurement. In: Li, S., Jin, Q., Jiang, X., Park, J. (eds) Frontier and Future Development of Information Technology in Medicine and Education. Lecture Notes in Electrical Engineering, vol 269. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7618-0_405
Download citation
DOI: https://doi.org/10.1007/978-94-007-7618-0_405
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-7617-3
Online ISBN: 978-94-007-7618-0
eBook Packages: EngineeringEngineering (R0)