Abstract
Pituitary adenomas are the most common sellar pathology. They can be classified according to size (micro vs. macroadenomas) and according to endocrine function (active vs. inactive). Indications for surgical removal include macroadenomas causing compression of neighboring structures and endocrine-active adenomas that cause detrimental systemic effects, as seen in acromegaly and Cushing’s disease. The majority of pituitary tumors can be safely and effectively removed through an endonasal, transsphenoidal route. Historically, this procedure has been performed under microscopic visualization; however, the recent emergence and evolution of endoscopic techniques have gained acceptance among skull base surgeons managing these lesions. The endoscope may be used as the sole source of visualization or as an adjunct in the microscopic approach. Its increased luminosity and angled profile grants the surgeon the possibility of visualization of lateral and posterior components of the sellar compartment, a feature particularly useful in macroadenomas invading the cavernous sinuses. In this chapter we describe the surgical technique, indications and complication avoidance strategies of the microscopic, endoscope-assisted transsphenoidal removal of pituitary adenomas.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Catapano D, Sloffer CA, Frank G, Pasquini E, D’Angelo VA, Lanzino G (2006) Comparison between the microscope and endoscope in the direct endonasal extended transsphenoidal approach: anatomical study. J Neurosurg 104(3):419–425
Cushing H (1912) The Pituitary body and its disorders: clinical states produced by disorders of the hypophysis cerebri. J.B. Lippincott, Philadelphia, pp 296–305
Dehdashti AR, Ganna A, Karabatsou K, Gentili F (2008) Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series. Neurosurgery 62(5):1006–1015, discussion 1015–1007
Dusick JR, Esposito F, Malkasian D, Kelly DF (2007) Avoidance of carotid artery injuries in transsphenoidal surgery with the Doppler probe and micro-hook blades. Neurosurgery 60(4 Suppl 2):322–328, discussion 328–329
Esposito F, Dusick JR, Fatemi N, Kelly DF (2007) Graded repair of cranial base defects and cerebrospinal fluid leaks in transsphenoidal surgery. Neurosurgery 60(4 Suppl 2):295–303, discussion 303–294
Fatemi N, Dusick JR, de Paiva Neto MA, Kelly DF (2008a) The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience. Neurosurgery 63(4 Suppl 2):244–256, discussion 256
Fatemi N, Dusick JR, Malkasian D, McArthur DL, Emerson J, Schad W, Kelly DF (2008b) A short trapezoidal speculum for suprasellar and infrasellar exposure in endonasal transsphenoidal surgery. Neurosurgery 62(5 Suppl 2):ONS325–ONS329, discussion ONS329-330
Fatemi N, Dusick JR, Mattozo C, McArthur DL, Cohan P, Boscardin J, Wang C, Swerdloff RS, Kelly DF (2008c) Pituitary hormonal loss and recovery after transsphenoidal adenoma removal. Neurosurgery 63(4):709–718, discussion 718–709
Fernandez-Miranda JC, Prevedello DM, Madhok R, Morera V, Barges-Coll J, Reineman K, Snyderman CH, Gardner P, Carrau R, Kassam AB (2009) Sphenoid septations and their relationship with internal carotid arteries: anatomical and radiological study. Laryngoscope 119(10):1893–1896
Frank G, Pasquini E (2002) Endoscopic endonasal approaches to the cavernous sinus: surgical approaches. Neurosurgery 50(3):675
Frank G, Pasquini E (2006) Endoscopic endonasal cavernous sinus surgery, with special reference to pituitary adenomas. Front Horm Res 34:64–82
Frank G, Pasquini E, Farneti G, Mazzatenta D, Sciarretta V, Grasso V, Faustini Fustini M (2006) The endoscopic versus the traditional approach in pituitary surgery. Neuroendocrinology 83(3–4):240–248
Hardy J, Somma M (1979) Acromegaly. Surgical treatment by transsphenoidal microsurgical removal of the pituitary adenoma. In: Collins WF, Tindall GT (eds) Clinical management of pituitary disorders. Raven, New York, pp 209–217
Jagannathan J, Smith R, DeVroom HL, Vortmeyer AO, Stratakis CA, Nieman LK, Oldfield EH (2009) Outcome of using the histological pseudocapsule as a surgical capsule in cushing disease. J Neurosurg 111(3):531–539
Jane JA Jr, Thapar K, Laws ER Jr (2001) Acromegaly: historical perspectives and current therapy. J Neurooncol 54(2):129–137
Jane JA Jr, Thapar K, Kaptain GJ, Maartens N, Laws ER Jr (2002) Pituitary surgery: transsphenoidal approach. Neurosurgery 51(2):435–442, discussion 442–434
Jho HD, Carrau RL (1997) Endoscopic endonasal transsphenoidal surgery: experience with 50 patients. J Neurosurg 87(1):44–51
Kassam A, Snyderman C, Carrau R (2004) An evolving paradigm to the ventral skull base. Skull Base 14(suppl 1)
Kassam A, Snyderman CH, Carrau RL, Gardner P, Mintz A (2005a) Endoneurosurgical hemostasis techniques: lessons learned from 400 cases. Neurosurg Focus 19(1):E7
Kassam A, Snyderman CH, Mintz A, Gardner P, Carrau RL (2005b) Expanded endonasal approach: the rostrocaudal axis. Part I. Crista galli to the sella turcica. Neurosurg Focus 19(1):E3
Kawamata T, Iseki H, Ishizaki R, Hori T (2002a) Minimally invasive endoscope-assisted endonasal trans-sphenoidal microsurgery for pituitary tumors: experience with 215 cases comparing with sublabial trans-sphenoidal approach. Neurol Res 24(3):259–265
Kawamata T, Kamikawa S, Iseki H, Hori T (2002b) Flexible endoscope-assisted endonasal transsphenoidal surgery for pituitary tumors. Minim Invasive Neurosurg 45(4):208–210
Kelly DF (2007) Transsphenoidal surgery for cushing’s disease: a review of success rates, remission predictors, management of failed surgery, and Nelson’s syndrome. Neurosurg Focus 23(3):E5
Kelly DF, Oskouian RJ, Fineman I (2001) Collagen sponge repair of small cerebrospinal fluid leaks obviates tissue grafts and cerebrospinal fluid diversion after pituitary surgery. Neurosurgery 49(4):885–889, discussion 889–890
Kleinman HK, Klebe RJ, Martin GR (1981) Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol 88(3):473–485
Lasio G, Ferroli P, Felisati G, Broggi G (2002) Image-guided endoscopic transnasal removal of recurrent pituitary adenomas. Neurosurgery 51(1):132–136, discussion 136–137
Laws ER, Reitmeyer M, Thapar K, Vance ML (2002) Cushing’s disease resulting from pituitary corticotrophic microadenoma. Treatment results from transsphenoidal microsurgery and gamma knife radiosurgery. Neurochirurgie 48(2–3 Pt 2):294–299
Liu JK, Das K, Weiss MH, Laws ER Jr, Couldwell WT (2001) The history and evolution of transsphenoidal surgery. J Neurosurg 95(6):1083–1096
Mattozo CA, Dusick JR, Esposito F, Mora H, Cohan P, Malkasian D, Kelly DF (2006) Suboptimal sphenoid and sellar exposure: a consistent finding in patients treated with repeat transsphenoidal surgery for residual endocrine-inactive macroadenomas. Neurosurgery 58(5):857–865, discussion 857–865
McDonald TJ, Laws ER Jr (1982) Historical aspects of the management of pituitary disorders with emphasis on transsphenoidal surgery. In: Laws ER Jr, Randall RV, Kern EB, Abboud CF (eds) The management of pituitary adenomas and related lesions with emphasis on transsphenoidal microsurgery. Appleton, New York, pp 1–13
McLaughlin N, Eisenberg A, Cohan P, Chaloner C, Kelly DF (2012) The value of endoscopy for maximizing tumor removal in endonasal transsphenoidal pituitary adenoma surgery. J Neurosurg 118:613–620
Narotam PK, Van Dellen JR, Bhoola K, Raidoo D (1993) Experimental evaluation of collagen sponge as a dural graft. Br J Neurosurg 7(6):635–641
Narotam PK, van Dellen JR, Bhoola KD (1995) A clinicopathological study of collagen sponge as a dural graft in neurosurgery. J Neurosurg 82(3):406–412
Oldfield EH, Vortmeyer AO (2006) Development of a histological pseudocapsule and its use as a surgical capsule in the excision of pituitary tumors. J Neurosurg 104(1):7–19
Powell M (2009) Microscope and endoscopic pituitary surgery. Acta Neurochir 151(7):723–728
Prevedello DM, Doglietto F, Jane JA Jr, Jagannathan J, Han J, Laws ER Jr (2007) History of endoscopic skull base surgery: its evolution and current reality. J Neurosurg 107(1):206–213
Prevedello DM, Kassam AB, Gardner P, Zanation A, Snyderman CH, Carrau RL (2010) “Q-tip” retractor in endoscopic cranial base surgery. Neurosurgery 66(2):363–366, discussion 366–367
Rotenberg B, Tam S, Ryu WH, Duggal N (2010) Microscopic versus endoscopic pituitary surgery: a systematic review. Laryngoscope 120(7):1292–1297
Spencer WR, Das K, Nwagu C, Wenk E, Schaefer SD, Moscatello A, Couldwell WT (1999) Approaches to the sellar and parasellar region: anatomic comparison of the microscope versus endoscope. Laryngoscope 109(5):791–794
Wilson CB, Dempsey LC (1978) Transsphenoidal microsurgical removal of 250 pituitary adenomas. J Neurosurg 48(1):13–22
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Filho, L.F.S.D. et al. (2014). Pituitary Adenomas: Treatment Using the Endonasal Approach. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 12. Tumors of the Central Nervous System, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7217-5_18
Download citation
DOI: https://doi.org/10.1007/978-94-007-7217-5_18
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-7216-8
Online ISBN: 978-94-007-7217-5
eBook Packages: MedicineMedicine (R0)