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Androgen Receptor and Steroidogenesis Pathway Control

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Prostate Cancer: Shifting from Morphology to Biology

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Abstract

Prostate cancer is the most common male malignancy and the leading cause of mortality in western countries. Androgens, the hormones that regulate prostate development and physiology, play a pivotal role also in the maintenance and progression of prostate cancer (Chen et al, Curr Opin Pharmacol, 8:440–448, 2008). Approximately 80–90 % of these tumors are dependent on androgen at initial diagnosis. Therapies that counteract androgen, by reducing its levels, blocking it, or antagonizing the androgen receptor (AR) and its target genes, represent the mainstay of treatment for prostate cancer (Chen et al, Curr Opin Pharmacol, 8:440–448, 2008). However, androgen ablation therapy ultimately fails because prostate cancer progresses to a hormone refractory state.

This chapter focuses on the role of AR-coactivators in prostate cancerogenesis.

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Authors and Affiliations

  1. Department of Biochemistry and Medical Biotechnology, Federico II University, via S. Pansini, n.5, Naples, Italy

    Simona Romano, Rita Bisogni & Maria Fiammetta Romano

Authors
  1. Simona Romano
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  2. Rita Bisogni
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  3. Maria Fiammetta Romano
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Correspondence to Simona Romano .

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Editors and Affiliations

  1. Biomedical Advanced Sciences Pathology Section, University Federico II of Naples, Naples, Italy

    Stefania Staibano

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Romano, S., Bisogni, R., Romano, M.F. (2013). Androgen Receptor and Steroidogenesis Pathway Control. In: Staibano, S. (eds) Prostate Cancer: Shifting from Morphology to Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7149-9_4

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