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Role of NADPH Oxidase in Beta Cell Dysfunction

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Islets of Langerhans, 2. ed.

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Abstract

Dysfunction of pancreatic beta cells and loss of beta cell mass is a major factor in the development of diabetes. Currently there is no cure for diabetes, and available therapies do not focus on halting or reversing the loss of beta cell function. New strategies to preserve beta cells in diabetes are needed. Conferring protection to the beta cells against the effects of sustained intracellular reactive oxygen species (ROS) presents a novel approach to preserve beta cell mass. Important contributors to increases in intercellular ROS in beta cells are nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzymes. Discussed in this review are the roles of NADPH oxidases in the beta cell, their contribution to beta cell dysfunction, and new emerging selective inhibitors of NADPH oxidase.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA

    Dr. Jessica R. Weaver

  2. Department of Microbiology and Molecular Cell Biology, Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes Center, W. Olney Road, Norfolk, VA, USA

    Prof. David A. Taylor-Fishwick

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  1. Dr. Jessica R. Weaver
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Correspondence to David A. Taylor-Fishwick .

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  1. Södersjukhuset, Karolinska Institutet Dept. Clinical Research & Education, Stockholm, Sweden

    Md. Shahidul Islam

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Weaver, J.R., Taylor-Fishwick, D.A. (2014). Role of NADPH Oxidase in Beta Cell Dysfunction. In: Islam, M. (eds) Islets of Langerhans, 2. ed.. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6884-0_46-3

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