Abstract
The subjectivity of systems participators emerges as ubiquitously occurring attainment of biological systems and facilitates multifaceted rationalizations for constituting the characteristic normativity of biological systems. The ‘living world’ of biological systems creates the background for establishing subjectivity of socialized—that means reciprocally communicating—systems participators and allows the redirection of systems normativity by combined modularized approaches: (1) Biomodulatory interventions exemplarily show that the available background knowledge of biological systems participators and practices of the related communication-derived rules of the systems ‘living world’ may now be conveyed for scientific proof, namely to the accustomed object side of natural sciences. (2) Evolution-adjusted pathophysiology may now practically use the architecture of the ‘living world’. (3) Evolution-adjusted pathophysiology has access to the ‘living world’ of biological systems by providing the knowledge for evolving and redirecting the normativity of these systems. (4) Because of the assumed evolutionarily linked subjectivity of systems objects on the background of the systems ‘living world’ and the modular knowledge of systems participators, evolution fuses a dichotomy by simultaneously emerging in a directed and an undirected manner. In response, the modular knowledge of systems participators may be redeemed endogenously by ‘natural’ tumor evolution and ‘artificially’ (synthetic biology, gene transfection, etc.) by therapeutic approaches, i.e. combined modularized (top-down) or single track (bottom-up) interventions. The alternative to the introduction of a ‘living world’ of biological systems would be the assumption of some deeply grounded biological perspectives: Then, biological systems would disintegrate into the particularism of suggested relevant cuttings of the ‘living world’ in the sense of neopragmatism. Darwinian ‘selection’ as a possible principle to explain evolution history would be one of these perspectives.
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References
Reichle A, Hildebrandt GC (2009) Principles of modular tumor therapy. Cancer Microenviron 2(Suppl 1):227–237
Reichle A, Hildebrandt GC (2008) Systems biology: a therapeutic target for tumor therapy. Cancer Microenviron 1:159–170
Lin C, Yang L, Tanasa B et al (2009) Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139:1069–1083
Raaijmakers MH, Mukherjee S, Guo S et al (2010) Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464:852–857
Reichle A, Hildebrandt GC (2010) The comparative uncovering of tumor systems biology by modularly targeting tumor-associated inflammation. FROM MOLECULAR TO MODULAR TUMOR THERAPY. The Tumor Microenviron 3(4):287–303. doi:10.1007/978-90-481-9531-2
Reichle A, Hildebrandt GC (2010) Uncovering tumor systems biology by Biomodulatory therapy strategies. FROM MOLECULAR TO MODULAR TUMOR THERAPY. The Tumor Microenviron 3(4):287–303. doi:10. 1007/978-90-481-9531-2_13
Reichle A, Hildebrandt GC (2010) Searching for the ‘Metabolism’ of evolution. FROM MOLECULAR TO MODULAR TUMOR THERAPY. The Tumor Microenviron 3(4):305–309. doi:10.1007/978-90-481-9531-2_14
Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V (2012) Role of apoptosis in disease. Aging 4(5):330–349
Gurdon JB, Melton DA (2008) Nuclear reprogramming in cells. Science 322(5909):1811–1815 Review
Okita K, Yamanaka S (2011) Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci 366(1575):2198–2207 Review
Pitteri SJ, Kelly-Spratt KS, Gurley KE et al (2011) Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. Cancer Res 71:5090–5100
Haudek-Prinz VJ, Klepeisz P, Slany A, Griss J, Meshcheryakova A, Paulitschke V, Mitulovic G, Stöckl J, Gerner C (2012) Proteome signatures of inflammatory activated primary human peripheral blood mononuclear cells. J Proteomics 76:150–162
Paulitschke V, Gruber S, Hofstätter E, Haudek-Prinz V, Klepeisz P, Schicher N, Jonak C, Petzelbauer P, Pehamberger H, Gerner C, Kunstfeld R (2012) Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. PLoS One 7(9):e46103. doi:10.1371/journal.pone.0046103
Kiessling F, Lederle W (2010) Early detection of systems response: Molecular and functional imaging of angiogenesis. In: Reichle A, editor. FROM MOLECULAR TO MODULAR TUMOR THERAPY: The Tumor Microenviron 3(6):385–403. doi:10.1007/978-90-481-9531-2_20
Reichle A, Hildebrandt GC (2010) To be an object in a biological system: the necessity of a formal-pragmatic communication theory. FROM MOLECULAR TO MODULAR TUMOR THERAPY. The Tumor Microenviron 3(9):537–544. doi:10.1007/978-90-481-9531-2_26
Thomas F, Fisher D, Fort P et al (2013) Applying ecological and evolutionary theory to cancer: a long and winding road. Evol Appl 6(1):1–10
Ewald PW, Swain Ewald HA (2013) Toward a general evolutionary theory of oncogenesis. Evol Appl 6(1):70–81
Reichle A, Hildebrandt GC (2010) Searching for the ‘Metabolism’ of evolution. FROM MOLECULAR TO MODULAR TUMOR THERAPY. The Tumor Microenviron 3(4):305–309. doi:10.1007/978-90-481-9531-2_14
Darwin C (2009) On the origin of species by means of natural selection, or the preservation of favoured races in the struggle for life. John Murray, London 1859
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Reichle, A. (2013). The Subjectivity of Systems Objects as a Scientific Object. In: Reichle, A. (eds) Evolution-adjusted Tumor Pathophysiology:. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6866-6_23
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DOI: https://doi.org/10.1007/978-94-007-6866-6_23
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