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Host Molecular Chaperones: Cell Surface Receptors for Viruses

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Moonlighting Cell Stress Proteins in Microbial Infections

Part of the book series: Heat Shock Proteins ((HESP,volume 7))

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Abstract

Molecular chaperones play important roles in maintaining cellular homeostasis under normal conditions. They also participate in a post-translational quality control system, maintaining the correct conformation of proteins under changing environmental conditions. While most molecular chaperones localize in the cytosol, some can exist outside the cell and are involved in moonlighting activities. It has been reported that some molecular chaperones at the cell surface act as receptors for viruses. Viruses using molecular chaperones as their receptors take advantage of these molecules to enable efficient introduction of their genomes into the cell and/or for selection of favorable target cells and of replication-competent virions.

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Acknowledgements

This work was supported by Grants-in-Aid for Young Scientists (KAKENHI) from Japan Society for the Promotion of Science (JSPS) (JSPS KAKENHI Grant Numbers 23790496 and 25860336 T.H.), and Funding Program for Next Generation World-Leading Researchers (NEXT program) from JSPS (K.T.).

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  1. Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan

    Tomoyuki Honda & Keizo Tomonaga

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  1. Tomoyuki Honda
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  2. Keizo Tomonaga
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Correspondence to Tomoyuki Honda .

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  1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, Gray's Inn Road 256, London, WC1X 8LD, United Kingdom

    Brian Henderson

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Honda, T., Tomonaga, K. (2013). Host Molecular Chaperones: Cell Surface Receptors for Viruses. In: Henderson, B. (eds) Moonlighting Cell Stress Proteins in Microbial Infections. Heat Shock Proteins, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6787-4_19

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