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Scorpion Venom Research Around the World: Tityus serrulatus

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Abstract

Tityus serrulatus is considered the most dangerous scorpion in Brazil. It is widely distributed, especially in the Southeast region, and is responsible for the highest number and most severe accidents. This chapter focuses on Tityus serrulatus scorpion venom (Tsv) and aspires to unravel its complex composition with emphases on its isolated proteins, their targets, structures, and functions. It takes a closer look at the peptides related to the Na+ and K+ channel toxin families, NaTx and KTx, respectively, including their toxin precursors. Additionally, a hyaluronidase, a serine proteinase, metalloproteinases, and many other proteins/peptides, such as a nontoxic protein (Ts4), PAPE peptides, bradykinin-potentiating peptides (BPP), antimicrobial peptides (AMP), anionic peptides, and venom peptides with undetermined functions, were reported.

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Authors and Affiliations

  1. Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil

    Karla de Castro Figueiredo Bordon, Camila Takeno Cologna & Eliane Candiani Arantes

  2. Laboratoire de Spectrométrie de Masse, CART/GIGA-R, Institut de Chimie, Bat. B6c, Université de Liège, Liège, B-4000, Belgium

    Camila Takeno Cologna

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  1. Karla de Castro Figueiredo Bordon
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  2. Camila Takeno Cologna
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  3. Eliane Candiani Arantes
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Correspondence to Eliane Candiani Arantes .

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  1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    P. Gopalakrishnakone

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Bordon, K.d.C.F., Cologna, C.T., Arantes, E.C. (2014). Scorpion Venom Research Around the World: Tityus serrulatus . In: Gopalakrishnakone, P. (eds) Scorpion Venoms. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6647-1_7-1

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