Skip to main content
SpringerLink
Log in

Survivors of Childhood Hodgkin’s Lymphoma After Treatment: Subsequent Solid Tumor Malignancies Based on Gender and Radiation Dose

  • Chapter
  • First Online:
Pediatric Cancer, Volume 4

Part of the book series: Pediatric Cancer ((PECA,volume 4))

  • 1613 Accesses

Abstract

Over the past few decades, dramatic advances in the treatment of childhood cancers have created a large and growing population of long-term survivors. Although many pediatric cancers can now be cured, the aggressive therapies employed in the recent era are associated with increased risks of a variety of adverse health effects, including subsequent malignant neoplasms (SMNs). Due to characteristics inherent to both the biology and treatment of Hodgkin’s lymphoma (HL), including the relatively high cure rate, a significant number of SMNs occur in HL survivors. The elevated risk of malignancy persists for decades after cure of HL is obtained, with no apparent plateau in risks over time. The cumulative mortality from second cancers exceeds deaths due to HL beyond 15–30 years after therapy for HL. The topic of SMNs after HL is broad and long-term data continue to accumulate. This chapter will specifically discuss second malignancies in survivors of childhood HL, focusing on gender and radiation dose.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Behrens C, Travis LB, Wistuba II, Davis S, Maitra A, Clarke EA, Lynch CF, Glimelius B, Wiklund T, Tarone R, Gazdar AF (2000) Molecular changes in second primary lung and breast cancers after therapy for Hodgkin’s disease. Cancer Epidemiol Biomark Prev 9:1027–1035

    CAS  Google Scholar 

  • Bhatia S, Yasui Y, Robison LL, Birch JM, Bogue MK, Diller L, DeLaat C, Fossati-Bellani F, Morgan E, Oberlin O, Reaman G, Ruymann FB, Tersak J, Meadows AT, Late Effects Study Group (2003) High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin’s disease: report from the Late Effects Study Group. J Clin Oncol 21:4386–4394

    Article  PubMed  Google Scholar 

  • Bhatti P, Veiga LH, Ronckers CM, Sigurdson AJ, Stovall M, Smith SA, Weathers R, Leisenring W, Mertens AC, Hammond S, Friedman DL, Neglia JP, Meadows AT, Donaldson SS, Sklar CA, Robison LL, Inskip PD (2010) Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the Childhood Cancer Survivor Study. Radiat Res 174:741–752

    Article  PubMed  CAS  Google Scholar 

  • Birdwell SH, Hancock SL, Varghese A, Cox RS, Hoppe RT (1997) Gastrointestinal cancer after treatment of Hodgkin’s disease. Int J Radiat Oncol Biol Phys 37:67–73

    Article  PubMed  CAS  Google Scholar 

  • Broeks A, Braaf LM, Wessels LF, van de Vijver M, De Bruin ML, Stovall M, Russell NS, van Leeuwen FE, Van ’t Veer LJ (2010) Radiation-associated breast tumors display a distinct gene expression profile. Int J Radiat Oncol Biol Phys 76:540–547

    Article  PubMed  Google Scholar 

  • Castellino SM, Geiger AM, Mertens AC, Leisenring WM, Tooze JA, Goodman P, Stovall M, Robison LL, Hudson MM (2011) Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Blood 117:1806–1816

    Article  PubMed  CAS  Google Scholar 

  • Constine LS, Tarbell N, Hudson MM, Schwartz C, Fisher SG, Muhs AG, Basu SK, Kun LE, Ng A, Mauch P, Sandhu A, Culakova E, Lyman G, Mendenhall N (2008) Subsequent malignancies in children treated for Hodgkin’s disease: associations with gender and radiation dose. Int J Radiat Oncol Biol Phys 72:24–33

    Article  PubMed  Google Scholar 

  • Dores GM, Metayer C, Curtis RE, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, van Leeuwen FE, Holowaty EJ, Andersson M, Wiklund T, Joensuu T, Van’t Veer MB, Stovall M, Gospodarowicz M, Travis LB (2002) Second malignant neoplasms among long-term survivors of Hodgkin’s disease: a population-based evaluation over 25 years. J Clin Oncol 20:3484–3494

    Article  PubMed  Google Scholar 

  • Elkin EB, Klem ML, Gonzales AM, Ishill NM, Hodgson D, Ng AK, Marks LB, Weidhaas J, Freedman GM, Miller RC, Constine LS, Myrehaug S, Yahalom J (2011) Characteristics and outcomes of breast cancer in women with and without a history of radiation for Hodgkin’s lymphoma: a multi-institutional, matched cohort study. J Clin Oncol 29:2466–2473

    Article  PubMed  Google Scholar 

  • Green DM, Hyland A, Barcos MP, Reynolds JA, Lee RJ, Hall BC, Zevon MA (2000) Second malignant neoplasms after treatment for Hodgkin’s disease in childhood or adolescence. J Clin Oncol 18:1492–1499

    PubMed  CAS  Google Scholar 

  • Hancock SL, Tucker MA, Hoppe RT (1993) Breast cancer after treatment of Hodgkin’s disease. J Natl Cancer Inst 85:25–31

    Article  PubMed  CAS  Google Scholar 

  • Hewitt M, Weiner S, Simone J (2003) Childhood cancer survivorship: improving care and quality of life. The National Academies Press, Washington, DC. Accessed at http://www.nap.edu/openbook.php?record_id=10767&page=R1

    Google Scholar 

  • Hildreth NG, Shore RE, Dvoretsky PM (1989) The risk of breast cancer after irradiation of the thymus in infancy. N Engl J Med 321:1281–1284

    Article  PubMed  CAS  Google Scholar 

  • Hodgson DC, Gilbert ES, Dores GM, Schonfeld SJ, Lynch CF, Storm H, Hall P, Langmark F, Pukkala E, Andersson M, Kaijser M, Joensuu H, Fossa SD, Travis LB (2007) Long-term solid cancer risk among 5-year survivors of Hodgkin’s lymphoma. J Clin Oncol 25:1489–1497

    Article  PubMed  Google Scholar 

  • Inskip PD, Curtis RE (2007) New malignancies following childhood cancer in the United States, 1973–2002. Int J Cancer 121:2233–2240

    Article  PubMed  CAS  Google Scholar 

  • Inskip PD, Robison LL, Stovall M, Smith SA, Hammond S, Mertens AC, Whitton JA, Diller L, Kenney L, Donaldson SS, Meadows AT, Neglia JP (2009) Radiation dose and breast cancer risk in the childhood cancer survivor study. J Clin Oncol 27:3901–3907

    Article  PubMed  Google Scholar 

  • Inskip PD, Stovall M, Flannery JT (1994) Lung cancer risk and radiation dose among women treated for breast cancer. J Natl Cancer Inst 86:983–988

    Article  PubMed  CAS  Google Scholar 

  • Kelly KM, Sposto R, Hutchinson R, Massey V, McCarten K, Perkins S, Lones M, Villaluna D, Weiner M (2011) BEACOPP chemotherapy is a highly effective regimen in children and adolescents with high-risk Hodgkin lymphoma: a report from the Children’s Oncology Group. Blood 117:2596–2603

    Article  PubMed  CAS  Google Scholar 

  • Koh ES, Tran TH, Heydarian M, Sachs RK, Tsang RW, Brenner DJ, Pintilie M, Xu T, Chung J, Paul N, Hodgson DC (2007) A comparison of mantle versus involved-field radiotherapy for Hodgkin’s lymphoma: reduction in normal tissue dose and second cancer risk. Radiat Oncol 2:13

    Article  PubMed  Google Scholar 

  • Le Vu B, de Vathaire F, Shamsaldin A, Hawkins MM, Grimaud E, Hardiman C, Diallo I, Vassal G, Bessa E, Campbell S, Panis X, Daly-Schveitzer N, Lagrange JL, Zucker JM, Eschwege F, Chavaudra J, Lemerle J (1998) Radiation dose, chemotherapy, and risk of osteosarcoma after solid tumours during childhood. Int J Cancer 77:370–377

    Article  PubMed  Google Scholar 

  • Metayer C, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, Joensuu T, van Leeuwen FE, Van’t Veer MB, Curtis RE, Holowaty EJ, Andersson M, Wiklund T, Gospodarowicz M, Travis LB (2000) Second cancers among long-term survivors of Hodgkin’s disease diagnosed in childhood and adolescence. J Clin Oncol 18:2435–2443

    PubMed  CAS  Google Scholar 

  • Milano MT, Li H, Constine LS, Travis LB (2011) Survival after second primary lung cancer: a population-based study of 187 Hodgkin lymphoma patients. Cancer 117:5538–5547

    Article  PubMed  Google Scholar 

  • Milano MT, Li H, Gail MH, Constine LS, Travis LB (2010) Long-term survival among patients with Hodgkin’s lymphoma who developed breast ­cancer: a population-based study. J Clin Oncol 28:5088–5096

    Article  PubMed  Google Scholar 

  • Ng AK, Bernardo MV, Weller E, Backstrand K, Silver B, Marcus KC, Tarbell NJ, Stevenson MA, Friedberg JW, Mauch PM (2002) Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 100:1989–1996

    Article  PubMed  CAS  Google Scholar 

  • Olsen JH, Garwicz S, Hertz H, Jonmundsson G, Langmark F, Lanning M, Lie SO, Moe PJ, Moller T, Sankila R (1993) Second malignant neoplasms after cancer in childhood or adolescence. Nordic society of paediatric haematology and oncology association of the nordic cancer registries. BMJ 307:1030–1036

    Article  PubMed  CAS  Google Scholar 

  • Pierce DA, Sharp GB, Mabuchi K (2003) Joint effects of radiation and smoking on lung cancer risk among atomic bomb survivors. Radiat Res 159:511–520

    Article  PubMed  CAS  Google Scholar 

  • Reulen RC, Frobisher C, Winter DL, Kelly J, Lancashire ER, Stiller CA, Pritchard-Jones K, Jenkinson HC, Hawkins MM, British Childhood Cancer Survivor Study Steering Group (2011) Long-term risks of subsequent primary neoplasms among survivors of childhood cancer. JAMA 305:2311–2319

    Article  PubMed  CAS  Google Scholar 

  • Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice JD Jr (1995) Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141:259–277

    Article  PubMed  CAS  Google Scholar 

  • Sigurdson AJ, Ronckers CM, Mertens AC, Stovall M, Smith SA, Liu Y, Berkow RL, Hammond S, Neglia JP, Meadows AT, Sklar CA, Robison LL, Inskip PD (2005) Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study: a nested case-control study. Lancet 365:2014–2023

    Article  PubMed  Google Scholar 

  • Swerdlow AJ, Barber JA, Hudson GV, Cunningham D, Gupta RK, Hancock BW, Horwich A, Lister TA, Linch DC (2000) Risk of second malignancy after Hodgkin’s disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 18:498–509

    PubMed  CAS  Google Scholar 

  • Swerdlow AJ, Schoemaker MJ, Allerton R, Horwich A, Barber JA, Cunningham D, Lister TA, Rohatiner AZ, Vaughan Hudson G, Williams MV, Linch DC (2001) Lung cancer after Hodgkin’s disease: a nested case-control study of the relation to treatment. J Clin Oncol 19:1610–1618

    PubMed  CAS  Google Scholar 

  • Tarbell NJ, Gelber RD, Weinstein HJ, Mauch P (1993) Sex differences in risk of second malignant tumours after Hodgkin’s disease in childhood. Lancet 341:1428–1432

    Article  PubMed  CAS  Google Scholar 

  • Travis LB, Gospodarowicz M, Curtis RE, Clarke EA, Andersson M, Glimelius B, Joensuu T, Lynch CF, van Leeuwen FE, Holowaty E, Storm H, Glimelius I, Pukkala E, Stovall M, Fraumeni JF Jr, Boice JD Jr, Gilbert E (2002) Lung cancer following chemotherapy and radiotherapy for Hodgkin’s disease. J Natl Cancer Inst 94:182–192

    Article  PubMed  Google Scholar 

  • Travis LB, Hill DA, Dores GM, Gospodarowicz M, van Leeuwen FE, Holowaty E, Glimelius B, Andersson M, Wiklund T, Lynch CF, Van’t Veer MB, Glimelius I, Storm H, Pukkala E, Stovall M, Curtis R, Boice JD Jr, Gilbert E (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 290:465–475

    Article  PubMed  Google Scholar 

  • Tucker MA, Jones PH, Boice JD Jr, Robison LL, Stone BJ, Stovall M, Jenkin RD, Lubin JH, Baum ES, Siegel SE (1991) Therapeutic radiation at a young age is linked to subsequent thyroid cancer. The Late Effects Study Group. Cancer Res 51:2885–2888

    PubMed  CAS  Google Scholar 

  • UNSCEAR 2000 report: sources and effects of ionizing radiation [report to General Assembly, with scientific annexes]. http://www.unscear.org/unscear/en/publications.html

  • van den Belt-Dusebout AW, Aleman BM, Besseling G, de Bruin ML, Hauptmann M, Van’t Veer MB, de Wit R, Ribot JG, Noordijk EM, Kerst JM, Gietema JA, van Leeuwen FE (2009) Roles of radiation dose and chemotherapy in the etiology of stomach cancer as a second malignancy. Int J Radiat Oncol Biol Phys 75:1420–1429

    Article  PubMed  Google Scholar 

  • Van Leeuwen FE, Klokman WJ, Stovall M, Hagenbeek A, van den Belt-Dusebout AW, Noyon R, Boice JD Jr, Burgers JM, Somers R (1995) Roles of radiotherapy and smoking in lung cancer following Hodgkin’s disease. J Natl Cancer Inst 87:1530–1537

    Article  PubMed  Google Scholar 

  • van Leeuwen FE, Klokman WJ, Veer MB, Hagenbeek A, Krol AD, Vetter UA, Schaapveld M, van Heerde P, Burgers JM, Somers R, Aleman BM (2000) Long-term risk of second malignancy in survivors of Hodgkin’s disease treated during adolescence or young adulthood. J Clin Oncol 18:487–497

    PubMed  Google Scholar 

  • van Leeuwen FE, Klokman WJ, Stovall M, Dahler EC, Van’t Veer MB, Noordijk EM, Crommelin MA, Aleman BM, Broeks A, Gospodarowicz M, Travis LB, Russell NS (2003) Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin’s disease. J Natl Cancer Inst 95:971–980

    Article  PubMed  Google Scholar 

  • Wolden SL, Lamborn KR, Cleary SF, Tate DJ, Donaldson SS (1998) Second cancers following pediatric Hodgkin’s disease. J Clin Oncol 16:536–544

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Wilmot Cancer Center/Strong Memorial Hospital, 601 Elmwood, Avenue, 647, Rochester, NY, 14642, USA

    Sughosh Dhakal, Paul Youn, Michael T. Milano & Louis S. Constine

Authors
  1. Sughosh Dhakal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Youn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael T. Milano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Louis S. Constine
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sughosh Dhakal .

Editor information

Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Dhakal, S., Youn, P., Milano, M.T., Constine, L.S. (2013). Survivors of Childhood Hodgkin’s Lymphoma After Treatment: Subsequent Solid Tumor Malignancies Based on Gender and Radiation Dose. In: Hayat, M. (eds) Pediatric Cancer, Volume 4. Pediatric Cancer, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6591-7_17

Download citation

Publish with us

Policies and ethics

Search

Navigation