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Gastric Electrical Stimulation: Twentieth Century Development to Twenty-First Century Implementation and Personalization of Programming

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New Advances in Gastrointestinal Motility Research

Part of the book series: Lecture Notes in Computational Vision and Biomechanics ((LNCVB,volume 10))

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Abstract

Gastroparesis is an incompletely understood disorder characterized by vomiting, nausea, abdominal pain, and related symptoms amongst evidence of delayed gastric emptying often refractory to medical therapy. Gastric electrical stimulation (GES), using higher than physiologic frequency and low energy, has been shown to be effective in many patients with refractory symptoms and received Humanitarian Use Device approval in 2000. A meta-analysis suggests GES is effective for symptom control and favorable in gastric emptying, nutritional status, and quality of life analysis. Recent work with endoscopically placed, temporary GES indicates trial stimulation is important in the evaluation of stimulation devices. In addition, approximately 50 % of patients responded to standard settings [4, Neurogastroenterol Motil 18(4):334–338, 2006] while other patients require higher energy settings for optimal response. These recent studies offer the potential for personalization of stimulation parameters in a given patient. For GES to be accepted and adopted on more widespread basis, further evaluation of individual responses to simulation must be determined and then correlated with individual histologic, electrophysiological and biochemical findings to optimally help patients. This chapter will discuss the historical development of current GES therapy.

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Acknowledgments

The authors would like to thank Evelyn Martin, LPNII and Angela Ashley, LPN I—GES nurses. We would also like to thank the staff of the GI Division, GI Laboratory, Department of Nuclear Medicine and Department of Pathology laboratory at the University of Mississippi Medical Center for their help.

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Authors and Affiliations

  1. School of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA

    James Griffith & Joy Hughes

  2. Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA

    Sumanth Daram, Ben Boatright, Archana Kedar & Thomas L. Abell

  3. Department of Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA

    Christopher J. Lahr

Authors
  1. James Griffith
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  2. Sumanth Daram
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  3. Ben Boatright
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  4. Joy Hughes
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  5. Christopher J. Lahr
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  6. Archana Kedar
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  7. Thomas L. Abell
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Corresponding author

Correspondence to Thomas L. Abell .

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Editors and Affiliations

  1. , Auckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand

    L. K. Cheng

  2. , Auckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand

    A. J. Pullan

  3. The Mayo Clinic, First Street SW 200, Rochester, 55905, Minnesota, USA

    G. Farrugia

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Griffith, J. et al. (2013). Gastric Electrical Stimulation: Twentieth Century Development to Twenty-First Century Implementation and Personalization of Programming. In: Cheng, L., Pullan, A., Farrugia, G. (eds) New Advances in Gastrointestinal Motility Research. Lecture Notes in Computational Vision and Biomechanics, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6561-0_8

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  • DOI: https://doi.org/10.1007/978-94-007-6561-0_8

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-6560-3

  • Online ISBN: 978-94-007-6561-0

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