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Co-transplantation of Islets with Mesenychymal Stem Cells Improves Islet Revascularization and Reversal of Hyperglycemia

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Stem Cells and Cancer Stem Cells, Volume 10

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 10))

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Abstract

Allogeneic islet transplantation offers the possibility to treat selected patients with Type 1 Diabetes Mellitus (T1DM). Limited availability of human pancreatic islets is a major obstacle to the more widespread use of islet transplantation as a therapy for the majority of patients with T1DM. This is exacerbated by extensive islet cell death during the early post transplantation period, which increases the number of islets required to achieve insulin independence. Additionally, suboptimal vascular engraftment contributes to the long term decline in graft function and survival. Mesenchymal Stem Cells (MSCs) play a major role in tissue repair through localized immunosuppressive effects and the release of soluble trophic factors to affect neighboring cells, making them excellent candidates for improving the engraftment and survival of transplanted islets. MSC-based modulations to the islet transplantation procedure therefore have the potential to reduce the number of donor islets required for each transplant recipient, which is likely to help in overcoming the problems associated with human islet donor shortage.

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Authors and Affiliations

  1. Diabetes Research Group, Division of Diabetes and Nutrition, School of Medicine, King’s College London, London, SE1 1UL, UK

    Aileen King & Chloe Rackham

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  1. Aileen King
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  2. Chloe Rackham
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Correspondence to Aileen King .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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King, A., Rackham, C. (2013). Co-transplantation of Islets with Mesenychymal Stem Cells Improves Islet Revascularization and Reversal of Hyperglycemia. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6262-6_25

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