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Role of the Immunological Environment in Cancer Initiation, Development and Progression

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The Tumor Immunoenvironment

Abstract

The last two decades have been characterized by a substantial progress in our understanding of the role of the immune system in tumor progression. We have learned how to manipulate the immune system to generate measurable tumor-specific immune responses. On the other hand, cancer cells induce malfunctions in immunity, as they manage to escape recognition and elimination by immune cells and factors. Chronic inflammation associated with a strong immunosuppression was also found to contribute to tumor initiation, progression and metastatic process.

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Authors and Affiliations

  1. Laboratory of Cell Mediated Immunity, SAIC-Frederick, Inc, Frederick National Laboratory, Frederick, MD, USA

    Anatoli Malyguine

  2. Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Heidelberg, Germany

    Viktor Umansky

  3. Department of Pathology, Division of Clinical Immunopathology, University of Pittsburgh Medical Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Michael R. Shurin

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  1. Anatoli Malyguine
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  2. Viktor Umansky
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  3. Michael R. Shurin
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Correspondence to Michael R. Shurin .

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Editors and Affiliations

  1. Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street Scaife Hal, Pittsburgh, 15213, Pennsylvania, USA

    Michael R. Shurin

  2. , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Viktor Umansky

  3. , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Post Office B, Frederick, 21702, Maryland, USA

    Anatoli Malyguine

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Malyguine, A., Umansky, V., Shurin, M.R. (2013). Role of the Immunological Environment in Cancer Initiation, Development and Progression. In: Shurin, M., Umansky, V., Malyguine, A. (eds) The Tumor Immunoenvironment. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6217-6_1

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