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Predictive and Prognostic Biomarkers for Colorectal Cancer

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Cancer Genomics

Abstract

The pathogenesis of colorectal cancer (CRC) is complex with at least two distinct pathways defined by different forms of genomic instability, and with each pathway including multiple sequential genetic and/or epigenetic changes. The treatment of CRC has evolved substantially over the past decade, due in part to a better understanding of the biology of the disease and development of new drugs including molecular-targeted agents. In this chapter we review molecular classification, prognostic markers and predictive markers in CRC. We focus on markers that have a substantial body of literature available to assess their potential role in routine clinical practice. Future strategies including gene-expression array based testing are also discussed.

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Authors and Affiliations

  1. Royal Melbourne Hospital, Parkville, VIC, Australia

    Lara Lipton & Michael Christie

  2. Ludwig Institute for Cancer Research, Parkville, VIC, Australia

    Lara Lipton & Michael Christie

  3. Systems Biology and Personalised Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia

    Oliver Sieber

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    Ulrich Pfeffer

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Lipton, L., Christie, M., Sieber, O. (2013). Predictive and Prognostic Biomarkers for Colorectal Cancer. In: Pfeffer, U. (eds) Cancer Genomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5842-1_5

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