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Induced Pluripotent Stem Cells

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Regenerative Medicine

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Abstract

Nearly 50 years have passed since the concept of nuclear reprogramming proposed for the first time. Since then, several approaches have been developed to convert somatic cells to a pluripotent state. Direct reprogramming with defined factors, is the newest of these approaches. This method requires just a few genes, and it also has a great reproducibility. Applying this method to humans seems to open the door to cell transplantation therapy without immune rejection, drug discovery, and elucidation of the pathogenesis of intractable diseases.

However, this concept still faces some issues which must be overcome before application due to a shortage of experience. This chapter introduces an overview of direct reprogramming as well as a special focus on its potentials and challenges.

S.Yamanaka is a member without salary of the scientific advisory boards of iPierian, iPS Academia Japan, Megakaryon Corporation, and Retina Institute Japan

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Acknowledgement

We’d like to thank the members of the Yamanaka laboratory and CiRA for their valuable support and discussions.

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  1. Center for iPS Cell Research and Application(CiRA), Institute for Integrated Cell-Material Sciences, Kyoto University, 53 Kawahara-cho Shogoin Sakyo-ku, Kyoto, 606-8507, Japan

    Keisuke Okita Ph.D., Kazutoshi Takahashi Ph.D. & Shinya Yamanaka M.D., Ph.D.

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  1. Keisuke Okita Ph.D.
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  2. Kazutoshi Takahashi Ph.D.
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  3. Shinya Yamanaka M.D., Ph.D.
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Correspondence to Shinya Yamanaka M.D., Ph.D. .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Okita, K., Takahashi, K., Yamanaka, S. (2013). Induced Pluripotent Stem Cells. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5690-8_8

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