Skip to main content

Pituitary Adenomas: Endoscopic Endonasal Transphenoidal Technique

  • Chapter
  • First Online:
Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

  • 1379 Accesses

Abstract

Endoscopic endonasal transsphenoidal surgery has gained increasing acceptance by neurosurgeons. In many centers throughout the world, this technique is now routinely used for the same indications as the conventional microsurgical technique. In 1963, Guiot and colleagues (La Presse Medicale 71:1225–1228, 1963) first proposed the use of an endoscope as part of a transnasorhinoseptal microsurgical approach. Endoscopic pituitary surgery differs from microscopic surgery, because it requires a steep learning curve for endoscopic skills and two-dimensional visualization. Gaining experience with the endoscope, some changes of the standard approaches have been performed satisfactorily for pituitary adenoma in parasellar and suprasellar location.

Treatment of pituitary adenomas invading the cavernous sinus is one of the great challenges in neurosurgical practice. Expanded surgical techniques should be performed for the removal of the cavernous sinus component in pituitary adenomas invading the cavernous sinus. Extended approaches are essential for reaching the area from lamina cribrosa to the cranio-cervical junction. Extended transsphenoidal approach was originally described by Weiss (Transnasal transsphenoidal approach. In: Apuzzo MLJ (ed) Surgery of the third ventricle, Williams and Wilkins, Baltimore, pp 476–494, 1987). Expanded and extended endoscopic approaches were reported overtime. The endoscopic transsphenoidal approach has been reported in the literature as a useful tool to treat sellar and parasellar lesions. Improved visualization with 0° and angled endoscopes allow the surgeon to identify anatomic landmarks. Angled endoscopes especially provide great advantages on the removal of tumor ­remnants at superior and lateral recesses. Different ­treatment modalities should be considered to achieve remission during the follow-up period in patients with secretuar pituitary adenomas.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alfieri A, Jho HD (2001) Endoscopic endonasal approaches to the cavernous sinus: surgical approaches. Neurosurgery 49:354–360

    PubMed  CAS  Google Scholar 

  • Cappabianca P, Cavallo LM, Colao A, de Divitiis E (2002) Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas. J Neurosurg 97:293–298

    Article  PubMed  Google Scholar 

  • Cappabianca P, Cavallo LM, de Divitiis E (2004) Endoscopic endonasal transsphenoidal surgery. Neurosurgery 55:933–941

    Article  PubMed  Google Scholar 

  • Cavallo LM, Cappabianca P, Galzio R, Iaconetta G, de Divitiis E, Tschabitscher M (2005) Endoscopic transnasal approach to the cavernous sinus versus transcranial route: anatomic study. Neurosurgery 56:379–389

    Article  PubMed  Google Scholar 

  • Ceylan S, Koc K, Anik I (2009) Extended endoscopic approaches for midline skull-base lesions. Neurosurg Rev 32(3):309–319

    Article  PubMed  Google Scholar 

  • Ceylan S, Koc K, Anik I (2010) Endoscopic endonasal transsphenoidal approach for pituitary adenomas invading the cavernous sinus. J Neurosurg 112(1):99–107

    Article  PubMed  Google Scholar 

  • Chi JG, Lee MH (1980) Anatomical observations of the development of the pituitary capsule. J Neurosurg 52:667–670

    Article  PubMed  CAS  Google Scholar 

  • Ciric I, Ragin A, Baumgartner C, Pierce D (1997) Complications of transsphenoidal surgery: results of a national survey, review, of the literature, and personal experience. Neurosurgery 40:225–237

    Article  PubMed  CAS  Google Scholar 

  • Couldwell WT, Sabit I, Weiss MH, Giannotta SL, Rice D (1997) Transmaxillary approach to the anterior cavernous sinus: a microanatomic study. Neurosurgery 40:1307–1311

    Article  PubMed  CAS  Google Scholar 

  • Das K, Spencer W, Nwagwu CI, Schaeffer S, Wenk E, Weiss MH, Couldwell WT (2001) Approaches to the sellar and parasellar region: anatomic comparison of endonasal-transsphenoidal, sublabialtranssphenoidal, and transethmoidal approaches. Neurol Res 23:51–54

    Article  PubMed  CAS  Google Scholar 

  • de Divitiis E, Cappabianca P, Cavallo LM, Esposito F, de Divitiis O, Messina A (2007) Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas. Neurosurgery 61:219–227

    Article  PubMed  Google Scholar 

  • Dolenc VV (1989) Relation of the cavernous sinus to the sella. In: Dolenc VV (ed) Anatomy and surgery of the cavernous sinus. Springer, Vienna, pp 118–130

    Chapter  Google Scholar 

  • Dusick JR, Esposito F, Kelly DF, Cohan P, DeSalles A, Becker DP, Martin NA (2005) The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors. J Neurosurg 102:832–841

    Article  PubMed  Google Scholar 

  • Frank G, Pasquini E (2006) Endoscopic endonasal cavernous sinus surgery, with special reference to pituitary adenomas. Front Horm Res 34:64–82

    Article  PubMed  Google Scholar 

  • Frank G, Pasquini E, Doglietto F, Mazzatenta D, Sciarretta V, Farneti G, Calbucci F (2006a) The endoscopic extended transsphenoidal approach for craniopharyngiomas. Neurosurgery 59:ONS75–ONS83

    PubMed  Google Scholar 

  • Frank G, Pasquini E, Farneti G, Mazzatenta D, Sciarretta V, Grasso V, Faustini FM (2006b) The endoscopic versus the traditional approach in pituitary surgery. Neuroendocrinology 83:240–248

    Article  PubMed  CAS  Google Scholar 

  • Guiot G, Rougerie J, Fourestler A, Fournier A, Comoy C, Vulmiere J, Groux R (1963) Une nouvelle technique endoscopique. Exploration endoscopiques intracraniennes. La Presse Medicale 71:1225–1228

    PubMed  CAS  Google Scholar 

  • Hadad G, Bassagasteguy L, Carrau RL, Mataza JC, Kassam A, Snyderman CH, Mintz A (2006) A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope 116:1882–1886

    Article  PubMed  Google Scholar 

  • Jankowski R, Auque J, Simon C, Marchal JC, Hepner H, Wayoff M (1992) Endoscopic pituitary tumor surgery. Laryngoscope 102:198–202

    Article  PubMed  CAS  Google Scholar 

  • Jho HD (2001) Endoscopic transsphenoidal surgery. J Neuro Oncol 54:187–195

    Article  CAS  Google Scholar 

  • Jho HD, Carrau RL (1997) Endoscopic endonasal transsphenoidal surgery: experience with 50 patients. J Neurosurg 87:44–51

    Article  PubMed  CAS  Google Scholar 

  • Jho HD, Ha HG (2004) Endoscopic endonasal skull base surgery: part 3—the clivus and posterior fossa. Minim Invasive Neurosurg 47:16–23

    Article  PubMed  Google Scholar 

  • Kassam A, Snyderman CH, Mintz A, Gardner P, Carrau RL (2005) Expanded endonasal approach: the rostrocaudal axis. Part I. Crista galli to the sella turcica. Neurosurg Focus 19(1):E3

    PubMed  Google Scholar 

  • Kitano M, Taneda M, Shimono T, Nakao Y (2008) Extended transsphenoidal approach for surgical management of pituitary adenomas invading the cavernous sinus. J Neurosurg 108:26–36

    Article  PubMed  Google Scholar 

  • Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33:610–618

    Article  PubMed  CAS  Google Scholar 

  • Koc K, Anik I, Ozdamar D, Cabuk B, Keskin G, Ceylan S (2006) The learning curve in endoscopic pituitary surgery and our experience. Neurosurg Rev 29:298–305

    Article  PubMed  Google Scholar 

  • Kristof RA, Schramm J, Redel L, Neuloh G, Wichers M, Klingmuller D (2002) Endocrinological outcome following first time transsphenoidal surgery for GH-, ACTH-, and PRL-secreting pituitary adenomas. Acta Neurochir 144:555–561

    Article  CAS  Google Scholar 

  • Lee EJ, Ahn JY, Noh T, Kim SH, Kim TS, Kim SH (2009) Tumor tissue identification in the pseudocapsule of pituitary adenoma: should the pseudocapsule be removed for total resection of pituitary adenoma? Neurosurgery 64(3 Suppl):62–69

    Google Scholar 

  • Oldfield EH, Vortmeyer AO (2006) Development of a histological pseudocapsule and its use as a surgical capsule in the excision of pituitary tumors. J Neurosurg 104(1):7–19

    Article  PubMed  Google Scholar 

  • Pamir MN, Kiliç T, Ozek MM, Ozduman K, Ture U (2006) Nonmeningeal tumours of the cavernous sinus: a surgical analysis. J Clin Neurosci 13:626–635

    Article  PubMed  Google Scholar 

  • Pamir MN, Kiliç T, Belirgen M, Abacioğlu U, Karabekiroğlu N (2007) Pituitary adenomas treated with gamma knife radiosurgery: volumetric analysis of 100 cases with minimum 3 year follow-up. Neurosurgery 61:270–280

    Article  PubMed  Google Scholar 

  • Peker S, Kurtkaya-Yapicier O, Kiliç T, Pamir MN (2005) Microsurgical anatomy of the lateral walls of the pituitary fossa. Acta Neurochir (Wien) 147(6):641–648

    Article  CAS  Google Scholar 

  • Snyderman CH, Kassam AB, Carrau R, Mintz A (2007) Endoscopic reconstruction of cranial base defects following endonasal skull base surgery. Skull Base 17:73–78

    Article  PubMed  Google Scholar 

  • Songtao Q, Yuntao L, Jun P, Chuanping H, Xiaofeng S (2009) Membranous layers of the pituitary gland: histological anatomic study and related clinical issues. Neurosurgery 64(3 Suppl):1–9

    Google Scholar 

  • Sonnenburg RE, White D, Ewend MG, Senior B (2004) The learning curve in minimally invasive pituitary surgery. Am J Rhinol 18(4):259–263

    PubMed  Google Scholar 

  • Weiss MH (1987) Transnasal transsphenoidal approach. In: Apuzzo MLJ (ed) Surgery of the third ventricle. Williams & Wilkins, Baltimore, pp 476–494

    Google Scholar 

  • Yasuda A, Campero A, Martins C, Rhoton AL Jr, Ribas GC (2004) The medial wall of the cavernous sinus: microsurgical anatomy. Neurosurgery 55:179–190

    Article  PubMed  Google Scholar 

  • Yokoyama S, Hirano H, Moroki K, Goto M, Imamura S, Kuratsu JI (2001) Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery 49:857–863

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Savas Ceylan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Ceylan, S., Anik, I. (2013). Pituitary Adenomas: Endoscopic Endonasal Transphenoidal Technique. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_23

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-5681-6_23

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5680-9

  • Online ISBN: 978-94-007-5681-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics