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Mechanical Stretch and Intermediate-Conductance Ca2+-Activated K+ Channels in Arterial Smooth Muscle Cells

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Mechanically Gated Channels and their Regulation

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 6))

Abstract

We describe the role and regulation of intermediate-conductance Ca2+-activated K+ (IKca) channels in cardiovascular pathophysiologies such as hypertension and restenosis. Blood vessels in vivo are continuously exposed to hemodynamic forces. These include shear stresses on the luminal surface generated by blood flow, cyclic distension due to the vascular wave caused by the pulsatility of the blood flow, and endocrine and local factors including angiotensin II (Ang II) and endothelin-1. Cell membrane stretch activates IKca channels. The activation is associated with extracellular Ca2+ influx through stretch-activated nonselective cation channels, and is also modulated by the F-actin cytoskeleton and the activation of PKC. Ang II activates IKca channels through the activation of protein kinase C, and the AT1 receptor is involved in the regulation of these channels. Mechanical stress and Ang II regulate the migration and proliferation of vascular smooth muscle cells. The modulation of IKca channels in artery smooth muscle cells has an important role in cell migration and proliferation. In this review, we will discuss the physiological and pathophysiological role of IKca channel in cells closely associated with vascular biology and the initiation and progression of vascular disease.

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Authors and Affiliations

  1. Department of Pediatrics, University of Tokushima, Kuramoto-cho-3-18-15, 770-8503, Tokushima, Japan

    Yasunobu Hayabuchi, Miho Sakata, Tatsuya Ohnishi & Shoji Kagami

Authors
  1. Yasunobu Hayabuchi
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  2. Miho Sakata
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  3. Tatsuya Ohnishi
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  4. Shoji Kagami
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Correspondence to Yasunobu Hayabuchi .

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Editors and Affiliations

  1. Chemical Department, Moscow State University, Vorobiovy Gory MSU, Moscow, 119899, Russia

    Andre Kamkin

  2. , Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str 1, Moscow, 117997, Russia

    Ilya Lozinsky

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Hayabuchi, Y., Sakata, M., Ohnishi, T., Kagami, S. (2012). Mechanical Stretch and Intermediate-Conductance Ca2+-Activated K+ Channels in Arterial Smooth Muscle Cells. In: Kamkin, A., Lozinsky, I. (eds) Mechanically Gated Channels and their Regulation. Mechanosensitivity in Cells and Tissues, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5073-9_5

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