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In Vivo Flow Cytometry Combined with Confocal Microscopy to Study Cancer Metastasis

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Handbook of Photonics for Biomedical Engineering

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Abstract

The quantification of circulating tumor cells (CTCs) is an emerging tool to diagnose and monitor patients with cancer metastasis. A number of methods have been developed to detect CTCs. However, conventional methods are limited by invasiveness, low sensitivity and difficulty to monitor CTCs. A novel technique named in vivo flow cytometry (IVFC) can overcome those limitations. A number of outstanding studies by IVFC have been published on cancer including leukemia, liver cancer and melanoma. However, there are still numerous questions about cancer metastasis, which could be investigated by IVFC combined with confocal microscopy.

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Author information

Authors and Affiliations

  1. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, 200030, Shanghai, China

    Xun-Bin Wei, Dan Wei, Rongrong Liu, Yuanzhen Suo & Xiao-Fu Weng

  2. Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, 200032, Shanghai, China

    Xun-Bin Wei & Zhi-Chao Fan

  3. Department of Chemistry, Fudan University, 220 Handan Road, 200433, Shanghai, China

    Xun-Bin Wei & Zhi-Chao Fan

Authors
  1. Xun-Bin Wei
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  2. Zhi-Chao Fan
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  3. Dan Wei
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  4. Rongrong Liu
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  5. Yuanzhen Suo
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  6. Xiao-Fu Weng
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Corresponding author

Correspondence to Xun-Bin Wei .

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Editors and Affiliations

  1. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong

    Aaron Ho-Pui Ho

  2. School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea (Republic of)

    Donghyun Kim

  3. Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

    Michael G. Somekh

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Wei, XB., Fan, ZC., Wei, D., Liu, R., Suo, Y., Weng, XF. (2017). In Vivo Flow Cytometry Combined with Confocal Microscopy to Study Cancer Metastasis. In: Ho, AP., Kim, D., Somekh, M. (eds) Handbook of Photonics for Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5052-4_17

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