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Calcium Signaling in Glioma Cells – The Role of Nucleotide Receptors

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Glioma Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 986))

Abstract

Calcium signaling is probably one of the evolutionary oldest and the most common way by which the signal can be transmitted from the cell environment to the cytoplasmic calcium binding effectors. Calcium signal is fast and due to diversity of calcium binding proteins it may have a very broad effect on cell behavior. Being a crucial player in neuronal transmission it is also very important for glia physiology. It is responsible for the cross-talk between neurons and astrocytes, for microglia activation and motility. Changes in calcium signaling are also crucial for the behavior of transformed glioma cells. The present Chapter summarizes molecular mechanisms of calcium signal formation present in glial cells with a strong emphasis on extracellular nucleotide-evoked signaling pathways. Some aspects of glioma C6 signaling such as the cross-talk between P2Y1 and P2Y12 nucleotide receptors in calcium signal generation will be discussed in-depth, to show complexity of machinery engaged in formation of this signal. Moreover, possible mechanisms of modulation of the calcium signal in diverse environments there will be presented herein. Finally, the possible role of calcium signal in glioma motility is also discussed. This is a very important issue, since glioma cells, contrary to the vast majority of neoplastic cells, cannot spread in the body with the bloodstream and, at least in early stages of tumor development, may expand only by means of sheer motility.

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Abbreviations

DAG:

Diacylglycerol

ER:

Endoplasmic reticulum

GPCR:

G-protein coupled receptor

IP3 :

Inositol 1,4,5-trisphosphate

IP3R:

IP3 receptor

2MeSADP:

2-Methylthio ADP

MLC:

Myosin light chain

NCX:

Sodium/calcium exchanger

PI3K:

Phosphatidylinositol 3-kinase PIP2Phosphatidylinositol 4,5-biphosphate

PLC:

Phospholipase C

PM:

Plasma membrane

PMCA:

Plasma membrane calcium ATPase

PSF:

Point spread function

RyR:

Ryanodine receptor

SERCA:

Sarco/endoplasmic reticulum calcium ATPase

SOC:

Store-operated channel

SOCE:

Store-operated calcium entry

STIM1,2:

Stromal interaction molecule 1,2

TRP channel:

Transient receptor potential channel

TRPA:

Ankyrin transient receptor potential channel

TRPC:

Canonical transient receptor potential channel

TRPM:

Melastatin transient receptor potential channel

TRPV:

Vanilloid transient receptor potential channel

VGCC:

Voltage-gated calcium channel

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Acknowledgements

The work in the Author’s Laboratory is supported by a grant NN303 070434 from the Ministry of Science and Higher Education.

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  1. Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL 02-093, Warsaw, Poland

    Dorota Wypych & Paweł Pomorski

  2. Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 9 via Balzaretti, 20133, Milan, Italy

    Dorota Wypych

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  1. Dorota Wypych
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  2. Paweł Pomorski
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Correspondence to Paweł Pomorski .

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  1. , Biochemistry, Nencki Institute of Experimental Biology, Pasteur 3, Warsaw, 02-093, Poland

    Jolanta Barańska

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Wypych, D., Pomorski, P. (2013). Calcium Signaling in Glioma Cells – The Role of Nucleotide Receptors. In: Barańska, J. (eds) Glioma Signaling. Advances in Experimental Medicine and Biology, vol 986. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4719-7_4

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