Abstract
The existence of cancer stem cells (CSCs), tumor-initiating cells (TICs) or cancer-initiating cells (CICs) has been a topic of hot debate in the field of cancer biology. The molecular mechanism(s) which this specific subpopulation of cells utilize to sustain themselves is currently under investigation. Recent studies demonstrate that CSCs express enhanced DNA repair mechanisms which can contribute to their ability to evade traditional cancer treatments. The following is a summary of the previous chapters presented in this text with an emphasis on the future of CSCs and their potential contribution to the development and identification of novel therapies and targets.
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References
Lobo NA et al (2007) The biology of cancer stem cells. Annu Rev Cell Dev Biol 23;675–699
Hurt EM, Farrar WL (2008) Cancer stem cells: the seeds of metastasis? Mol Interv 8(3):140–142
Tang C, Ang BT, Pervaiz S (2007) Cancer stem cell: target for anti-cancer therapy. FASEB J 21(14):3777–3785
Mathews L, Cabarcas S, Farrar W (2011) DNA repair: the culprit for tumor-initiating cell survival? Cancer Metast Rev 30(2):185–197
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© 2013 Springer Science+Business Media Dordrecht
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Cabarcas, S. (2013). The Future of DNA Repair and Cancer Stem Cells. In: Mathews, L., Cabarcas, S., Hurt, E. (eds) DNA Repair of Cancer Stem Cells. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4590-2_10
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DOI: https://doi.org/10.1007/978-94-007-4590-2_10
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