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Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection

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Endoplasmic Reticulum Stress in Health and Disease

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Abstract

In eukaryotic cells, calcium (Ca2  + ) stores form a complex web where the capability to take up and release the cation is spread among different but highly interconnected structures that are physically based on the most abundant intracellular membranes: i.e., those forming the endoplasmic reticulum (ER) and the mitochondrial networks. Main hubs of these infra-structures are the Mitochondria-Associated Membranes (MAMs), ER and mitochondria juxtaposed membrane domains whose precise composition and functionality are now emerging. Understanding how these intracellular networks control Ca2  + dynamics under physiological and pathological conditions is fundamental to life sciences. The relevance of this issue is documented by the extraordinarily large number of qualified contributions that can offer both extensive reviews and in-depth examinations of specific aspects. In this chapter we update the ER-mitochondria connection, with a special glance at the Ca2  + cross-talk, from different points of view: the molecules that are involved, either as essential building blocks or as modulators; the messages that travel between the two networks; the most novel technical approaches that allow us to answer old questions and open new perspectives.

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Abbreviations

AD:

Alzheimer’s Disease

Aeq:

Aequorin

[Ca2 + ]:

Ca2 + concentration

CCE:

Capacitative Ca2 + Entry

CNX:

Calnexin

COX-VIII:

Cytochrome c Oxidase Subunit VIII

Drp1:

dynamin-related protein 1

ER:

Endoplasmic Reticulum

FAD:

Familial Alzheimer’s Disease

Fis-1:

Fission protein 1

FRET:

Fluorescence Resonance Energy Transfer

GA:

Golgi Apparatus

GEM:

Glycosphingolipid-Enriched Microdomain

GFP:

Green Fluorescent Protein

grp75:

glucose-regulated protein 75

HSP70:

Heat Shock Protein 70

IMM:

Inner Mitochondrial Membrane

IMS:

Inter Membrane Space

IP3R:

Inositol 1,4,5 tris-Phosphate Receptor

MAMs:

Mitochondria-Associated Membranes

MCU:

Mitochondrial Ca2+ Uniporter

Mff:

Mitochondrial fission factor

Mfn2:

Mitofusin2

NCLX:

Na + /Ca2 +/Li+ exchanger

OMM:

Outer Mitochondrial Membrane

PDI:

Protein Disulfide-Isomerase

PML:

promyelocytic leukemia protein

PS1/2:

Presenilin-1 and -2

PTP:

Permeability Transition Pore

ROS:

Reactive Oxygen Species

RyR:

Ryanodine Receptor

SERCA:

Sarco-Endoplasmic Reticulum Ca2 + ATPase

Sig-1R:

Sigma-1Receptor

S1T:

SERCA1 Truncated form

SPCA1:

Secretory Pathway Ca2+ ATPase1

STIM:

STromal Interaction Molecule

TCA:

Tricarboxylic Acid

TEM:

Transmission Electron Microscopy

UPR:

Unfolded Protein Response

VDAC:

Voltage Dependent Anion Channel

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Padova, 35121, Viale G. Colombo 3, Padova, Italy

    Riccardo Filadi, Tullio Pozzan, Paola Pizzo & Cristina Fasolato

  2. Neuroscience Institute, National Research Council (CNR), Padova, Italy

    Tullio Pozzan

  3. Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Enrico Zampese

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  1. Dept Molec Cell Bio, K.U. Leuven, Harestraat/Gasthuisberg, B-3000 Leuven, 3000, Belgium

    Patrizia Agostinis

  2. School of Natural Science, Department of Biochemistry, NUI Galway, University Road, Galway, Ireland

    Samali Afshin

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Filadi, R., Zampese, E., Pozzan, T., Pizzo, P., Fasolato, C. (2012). Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection. In: Agostinis, P., Afshin, S. (eds) Endoplasmic Reticulum Stress in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4351-9_4

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