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The Coxiella burnetii Parasitophorous Vacuole

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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

Part of the book series: Advances in Experimental Medicine and Biology ((volume 984))

Abstract

Coxiella burnetii is a bacterial intracellular parasite of eucaryotic cells that replicates within a membrane-bound compartment, or “parasitophorous vacuole” (PV). With the exception of human macrophages/monocytes, the consensus model of PV trafficking in host cells invokes endolysosomal maturation culminating in lysosome fusion. C. burnetii resists the degradative functions of the vacuole while at the same time exploiting the acidic pH for metabolic activation. While at first glance the mature PV resembles a large phagolysosome, an increasing body of evidence indicates the vacuole is in fact a specialized compartment that is actively modified by the pathogen. Adding to the complexity of PV biogenesis is new data showing vacuole engagement with autophagic and early secretory pathways. In this chapter, we review current knowledge of PV nature and development, and discuss disparate data related to the ultimate maturation state of PV harboring virulent or avirulent C. burnetii lipopolysaccharide phase variants in human mononuclear phagocytes.

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Acknowledgements

We thank Dale Howe and Stacy Gilk for critical reading of the manuscript. This research was supported by the CNRS (E. G.), the Agencia Nacional de Promoción Científica y Tecnológica and SECTyP (Universidad Nacional de Cuyo) (M. I. C.) and the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases (R. A. H.)

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Authors and Affiliations

  1. URMITE CNRS UMR 6236 – IRD 3R198, Institut Fédératif de Recherche 48, Université de la Méditerranée, Marseille, France

    Eric Ghigo

  2. Laboratorio de Biología Celular y Molecular, Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    María I. Colombo

  3. Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th street, Hamilton, MT, 59840, USA

    Robert A. Heinzen

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  1. Eric Ghigo
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  2. María I. Colombo
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  3. Robert A. Heinzen
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Correspondence to Robert A. Heinzen .

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Editors and Affiliations

  1. Institute of Virology, Dept. of Rickettsiology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, 845 05, Slovakia

    Rudolf Toman

  2. Rocky Mountain Laboratories, Coxiella Pathogenesis Section, NIH/NIAID, South Fourth Street 903, Hamilton, 59840, Montana, USA

    Robert A. Heinzen

  3. , Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M, Joe H. Reynolds Medical Building, College Station 407, College Station, 77843-1114, Texas, USA

    James E. Samuel

  4. Institut Fédératif de Recherche 48, Les Maladies Infect Transmissibles, CNRS-IRD UMR 6236, Bd Jean Moulin 27, Marseille, Cedex 05, 13385, France

    Jean-Louis Mege

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Ghigo, E., Colombo, M.I., Heinzen, R.A. (2012). The Coxiella burnetii Parasitophorous Vacuole. In: Toman, R., Heinzen, R., Samuel, J., Mege, JL. (eds) Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium. Advances in Experimental Medicine and Biology, vol 984. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4315-1_8

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