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Astrocytoma Cell Line: Role of Brain Natriuretic Peptide

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Tumors of the Central Nervous System, Volume 8

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 8))

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Abstract

Brain natriuretic peptides (BNP) is widely distributed in central nervous system (CNS) structures like C type NP (CNP) and more than atrial NP (ANP). In contrast, NP receptors (NPRs) are mainly localized in astroglial cells in several brain regions, and astrocytes express predominantly the NPR-A subtype. Thus, NPs play an important role in the regulation of astrocyte functions including anti-apoptosis, anti-proliferation, and neuron-glia communication. The human astrocytoma cell line U373MG releases BNP, and hypoxia enhances the gene expression and release of BNP. Hypoxia-induced apoptosis in U373MG is increased by knockdown of BNP, whereas it is dampened by exogenous BNP, suggesting that not only endogenous but exogenous BNP functions as an anti-apoptotic molecule. BNP inhibits DNA synthesis by binding to NPR-C and localizing to nucleus of cancer cells, and exerts anti-proliferative effects in human glioblastomas cell line. Since NPs circulate normally in the human body and have no side effect on normal cells, BNP may be a novel therapeutic molecule against brain tumor.

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Authors and Affiliations

  1. Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan

    Tomohiro Osanai M.D., Chisato Katoh M.D. & Ken Okumura M.D.

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  1. Tomohiro Osanai M.D.
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  2. Chisato Katoh M.D.
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  3. Ken Okumura M.D.
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Correspondence to Tomohiro Osanai M.D. .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Osanai, T., Katoh, C., Okumura, K. (2012). Astrocytoma Cell Line: Role of Brain Natriuretic Peptide. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 8. Tumors of the Central Nervous System, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4213-0_1

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  • DOI: https://doi.org/10.1007/978-94-007-4213-0_1

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