Overview
- Discusses cancer cell biology in relation to Genome stability and Cell cycle regulation
- Unique assembly of experts in these fields who wrote a comprehensive and deep up-to-date overview
- Discusses models for the understanding of DNA damage-dependent signal transduction and regulation in human cells
Part of the book series: Subcellular Biochemistry (SCBI, volume 50)
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Table of contents (17 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.
This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
Editors and Affiliations
Bibliographic Information
Book Title: Genome Stability and Human Diseases
Editors: Heinz-Peter Nasheuer
Series Title: Subcellular Biochemistry
DOI: https://doi.org/10.1007/978-90-481-3471-7
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2010
Hardcover ISBN: 978-90-481-3470-0Published: 18 December 2009
Softcover ISBN: 978-94-007-3125-7Published: 01 March 2012
eBook ISBN: 978-90-481-3471-7Published: 11 December 2009
Series ISSN: 0306-0225
Series E-ISSN: 2542-8810
Edition Number: 1
Number of Pages: XVI, 340
Topics: Human Genetics, Oncology, Laboratory Medicine, Cytogenetics, Cancer Research, Cell Biology