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Primary Hepatic Tumors

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Atlas of PET/CT in Pediatric Patients

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Abstract

Liver tumors comprise 1–4 % of all solid tumors in the pediatric population. Among the subgroup of primary liver tumors, 60 % are malignant, with the most common being hepatoblastoma but also including hepatocellular carcinoma, rhabdomyosarcoma, angiosarcoma, rhabdoid tumor, undifferentiated sarcoma, and several rare tumors. The main role of 18F-FDG–PET/CT is tumor restaging in patients after chemotherapy and surgery and during follow-up. The ability of this imaging modality to reliably detect early recurrence and metastatic disease has been well demonstrated.

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References

  1. Agarwala S (2012) Primary malignant liver tumors in children. Indian J Pediatr 79:793–800

    Article  PubMed  Google Scholar 

  2. Ammann RA, Plaschkes J, Leibundgut K et al (1999) Congenital hepatoblastoma: a distinct entity? Med Pediatr Oncol 32:466–468

    Article  PubMed  CAS  Google Scholar 

  3. Herzog CE, Andrassy RJ, Eftekhari F et al (2000) Childhood cancers: hepatoblastoma. Oncologist 5:445–453

    Article  PubMed  CAS  Google Scholar 

  4. Litten JB, Tomlinson GE (2008) Liver tumors in children. Oncologist 13:812–820

    Article  PubMed  Google Scholar 

  5. Das CJ, Dhingra S, Gupta AK et al (2009) Imaging of paediatric liver tumours with pathological correlation. Clin Radiol 64:1015–1025

    Article  PubMed  CAS  Google Scholar 

  6. Chung EM, Lattin GE Jr, Cube R et al (2011) From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics 31:483–507

    Article  PubMed  Google Scholar 

  7. Zsíros J, Maibach R, Shafford E et al (2010) Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol 28:2584–2590

    Article  PubMed  Google Scholar 

  8. Avila LF, Luis AL, Hernandez F et al (2006) Liver transplantation for malignant tumours in children. Eur J Pediatr Surg 16:411–414

    Article  PubMed  CAS  Google Scholar 

  9. Perilongo G, Shafford E, Plaschkes J (2000) SIOPEL trials using preoperative chemotherapy in hepatoblastoma. Lancet Oncol 1:94–100

    Article  PubMed  CAS  Google Scholar 

  10. Moon SB, Shin HB, Seo JB et al (2011) Hepatoblastoma: 15-year experience and role of surgical treatment. J Korean Surg Soc 81:134–140

    Article  PubMed  Google Scholar 

  11. Abraham H, Dachman MD, Pakter RL et al (1987) Hepatoblastoma: radiologic-pathologic correlation in 50 cases. Radiology 164:15–19

    Google Scholar 

  12. King SJ, Babyn PS, Greenberg ML et al (1993) Value of CT in determining the resectability of hepatoblastoma before and after chemotherapy. AJR Am J Roentgenol 160:793–798

    Article  PubMed  CAS  Google Scholar 

  13. Miller JH, Greenspan BS (1985) Integrated imaging of hepatic tumors in childhood. Part I: Malignant lesions (primary and metastatic). Radiology 154:83–90

    PubMed  CAS  Google Scholar 

  14. Figarola MS, McQuiston SA, Wilson F et al (2005) Recurrent hepatoblastoma with localization by PET-CT. Pediatr Radiol 35:1254–1258

    Article  PubMed  Google Scholar 

  15. Sironi S, Messa C, Cistaro A et al (2004) Recurrent hepatoblastoma in orthotopic transplanted liver: detection with FDG positron emission tomography. AJR Am J Roentgenol 182:1214–1216

    Article  PubMed  CAS  Google Scholar 

  16. Philip I, Shun A, McCowage G et al (2005) Positron emission tomography in recurrent hepatoblastoma. Pediatr Surg Int 21:341–345

    Article  PubMed  Google Scholar 

  17. Mody RJ, Pohlen JA, Malde S et al (2006) FDG PET for the study of primary hepatic malignancies in children. Pediatr Blood Cancer 47:51–55

    Article  PubMed  Google Scholar 

  18. Wong KK, Lan LC, Lin SC et al (2004) The use of positron emission tomography in detecting hepatoblastoma recurrence – a cautionary tale. J Pediatr Surg 39:1779–1781

    Article  PubMed  Google Scholar 

  19. Bertagna F, Orlando E, Bosio G et al (2011) Incremental diagnostic value of F-18 FDG PET/CT over MRI in a pediatric patient with suspected hepatoblastoma and histologic diagnosis of focal nodular hyperplasia. Clin Nucl Med 36:305–308

    Article  PubMed  Google Scholar 

  20. Warfel KA, Hull MT (2006) Hepatoblastoma: an ultrastructural and immunohistochemical study. Ultrastruct Pathol 16:451–461

    Article  Google Scholar 

  21. Patel C, Kumar R (2007) Positron emission tomography and positron emission tomography – computerized tomography in pediatric patients. J Indian Assoc 12:120–124

    Article  Google Scholar 

  22. Exelby PR, Filler RM, Grosfeld JL (1975) Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics Surgical Section Survey – 1974. J Pediatr Surg 10:329–337

    Article  PubMed  CAS  Google Scholar 

  23. Katzenstein HM, Krailo MD, Malogolowkin MH et al (2003) Fibrolamellar hepatocellular carcinoma in children and adolescents. Cancer 97:2006–2012

    Article  PubMed  Google Scholar 

  24. Donnelly LF, Bisset GS 3rd (1998) Pediatric hepatic imaging. Radiol Clin North Am 36:413–427

    Article  PubMed  CAS  Google Scholar 

  25. Finegold MJ, Egler RA, Goss JA et al (2008) Liver tumors: pediatric population. Liver Transpl 14:1545–1556

    Article  PubMed  Google Scholar 

  26. Ni YH, Chang MH, Hsu HY et al (1991) Hepatocellular carcinoma in childhood. Clinical manifestations and prognosis. Cancer 68:1737–1741

    Article  PubMed  CAS  Google Scholar 

  27. Czauderna P, Mackinlay G, Perilongo G et al (2002) Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology Group. J Clin Oncol 20:2798–2804

    Article  PubMed  CAS  Google Scholar 

  28. Jha P, Chawla SC, Tavri S (2009) Pediatric liver tumors – a pictorial review. Eur Radiol 19:209–219

    Article  PubMed  Google Scholar 

  29. Lee JE, Jang JY, Jeong SW et al (2012) Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan. World J Gastroenterol 18:2979–2987

    Article  PubMed  CAS  Google Scholar 

  30. Talbot JN, Fartoux L, Balogova S et al (2010) Detection of hepatocellular carcinoma with PET/CT: a prospective comparison of 18F-fluorocholine and 18F-FDG in patients with cirrhosis or chronic liver disease. J Nucl Med 51:1699–1706

    Article  PubMed  Google Scholar 

  31. Dierckx R, Maes A, Peeters M et al (2009) FDG PET for monitoring response to local and locoregional therapy in HCC and liver metastases. Q J Nucl Med Mol Imaging 53:336–342

    PubMed  CAS  Google Scholar 

  32. Lee MK, Kwon CG, Hwang KH et al (2009) F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. Clin Nucl Med 34:107–108

    Article  PubMed  Google Scholar 

  33. Ma L, Liu YP, Geng CZ et al (2008) Undifferentiated embryonal sarcoma of liver in an old female: case report and review of the literature. World J Gastroenterol 14:7267–7270

    Article  PubMed  Google Scholar 

  34. Maggard MA, O’Connell JB, Ko CY (2004) Updated population-based review of carcinoid tumors. Ann Surg 240:117–122

    Article  PubMed  Google Scholar 

  35. Shi W, Johnston CF, Buchanan KD, Ferguson WR, Laird JD, Crothers JG, McIlrath EM (1998) Localization of neuroendocrine tumours with [111In] DTPA-octreotide scintigraphy (Octreoscan): a comparative study with CT and MR imaging. QJM 91:295–301

    Article  PubMed  CAS  Google Scholar 

  36. Krausz Y, Freedman N, Rubinstein R, Lavie E et al (2011) 68Ga-DOTA-NOC PET/CT imaging of neuroendocrine tumors: comparison with 111In-DTPA-octreotide. Mol Imaging Biol 13:583–593

    Article  PubMed  Google Scholar 

  37. Pasquali C, Rubello D, Sperti C et al (1998) Neuroendocrine tumor image: can 18F-fluorodeoxyglucose positron emission tomography detect tumors with poor prognosis and aggressive behavior? World J Surg 22:588–592

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Nuclear Medicine Unit, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, Via Consolare Valeria 1, Messina, 98125, Italy

    Natale Quartuccio MD

  2. Department of Nuclear Medicine, Positron Emission Tomography Center IRMET S.p.A., Euromedic Inc., Via Onorato Vigliani 89, Turin, 10100, Italy

    Angelina Cistaro MD

  3. Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy

    Angelina Cistaro MD

Authors
  1. Natale Quartuccio MD
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  2. Angelina Cistaro MD
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Correspondence to Angelina Cistaro MD .

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Editors and Affiliations

  1. Nuclear Medicine, Positron Emission Tomography Centre, Torino, Italy

    Angelina Cistaro

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Quartuccio, N., Cistaro, A. (2014). Primary Hepatic Tumors. In: Cistaro, A. (eds) Atlas of PET/CT in Pediatric Patients. Springer, Milano. https://doi.org/10.1007/978-88-470-5358-8_10

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  • DOI: https://doi.org/10.1007/978-88-470-5358-8_10

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  • Publisher Name: Springer, Milano

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  • Online ISBN: 978-88-470-5358-8

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