Abstract
The goal of harm reduction is to reduce both the individual and societal harms of drug use through knowledge-based interventions that change risk behaviors and risk settings. Chapter 84, “Harm Reduction Policies, Settings, and Challenges” in this textbook gives an overview of harm reduction as a public health policy. This chapter describes the main harm reduction interventions implemented in many countries around the world, synthesizes evidence on their effectiveness and risks, and summarizes key lessons learned. The focus is on illegal drugs, especially opioids and central nervous system stimulants. The interventions covered are opioid substitution treatment; needle and syringe programs; supervised drug consumption facilities; drug overdose prevention; outreach, peer education, and health promotion; testing, vaccination, and treatment of drug-related infectious diseases; interventions for stimulant users; and drug-related sexual risk reduction. Key themes stressed include the following: that harm reduction does not replace the need for treatment but adds to the capacity to respond effectively to the wide range of health and social challenges raised by drug use; that the scientific evidence shows that harm reduction interventions are effective in terms of their stated goals, as long as they are implemented appropriately within their contextual settings; and that single interventions are far more effective when implemented together as part of a broader public health policy, including steps to facilitate healthier living and safer social environments.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Amato L, Davoli M, Perucci CA, Ferri M, Faggiano F, Mattick RP (2005) An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research. J Subst Abus Treat 28:321–329
Booth RE, Kwiatkowski CF, Chitwood DD (2000) Sex related HIV risk behaviors: differential risks among injection drug users, crack smokers, and injection drug users who smoke crack. Drug Alcohol Depend 58:219–226
Caplehorn JR, Dalton MS, Haldar F, Petrenas AM, Nisbet JG (1996) Methadone maintenance and addicts’ risk of fatal heroin overdose. Subst Use Misuse 31:177–196
Castells X, Casas M, Pérez-Mañá C, Roncero C, Vidal X, Capellà D (2010) Efficacy of psychostimulant drugs for cocaine dependence. Cochrane Database Syst Rev (Online) CD007380
Centers for Disease Control and Prevention (CDC) (2010) The role of STD detection and treatment in HIV prevention – CDC fact sheet. CDC, Atlanta. http://www.cdc.gov/std/hiv/STDFact-STD-HIV.htm. Accessed 3 Mar 2013
Centers for Disease Control and Prevention (CDC) (2012a) Integrated prevention services for HIV infection, viral hepatitis, sexually transmitted diseases, and tuberculosis for persons who use drugs illicitly: summary guidance from CDC and the U.S. Department of Health and Human Services. MMWR 61(RR05):1–43. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6105a1.htm. Accessed 5 Mar 2013
Centers for Disease Control and Prevention (CDC) (2012b) Community-based opioid overdose prevention programs providing naloxone – United States, 2010. MMWR 61:101–105. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6106a1.htm. Accessed 13 Mar 2013
Centers for Disease Control and Prevention (CDC) (2012c) HIV infection and HIV-associated behaviors among injecting drug users – 20 cities, United States, 2009. MMWR 61(08):133–138. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6108a1.htm?s_cid=mm6108a1_w. Accessed 14 Mar 2013
Centers for Disease Control and Prevention (CDC) (2013) Opioids drive continued increase in drug overdose deaths. http://www.cdc.gov/media/releases/2013/p0220_drug_overdose_deaths.html. Accessed 14 Mar 2013
Coffin PO, Sullivan SD (2013) Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal. Ann Intern Med 158:1–9
Colfax G, Shoptaw S (2005) The methamphetamine epidemic: implications for HIV prevention and treatment. Curr HIV/AIDS Rep 2:194–199
Decorte T (2000) The taming of cocaine use in European and American cities. VUB University Press, Brussels
Degenhardt L, Bucello C, Mathers B, Briegleb C, Ali H, Hickman M, McLaren J (2011) Mortality among regular or dependent users of heroin and other opioids: a systematic review and meta-analysis of cohort studies. Addiction (Abingdon, England) 106:32–51
de Lima MS, de Oliveira Soares BG, Reisser AAP, Farrell M (2002) Pharmacological treatment of cocaine dependence: a systematic review. Addiction (Abingdon, England) 97:931–949
Department of Health and Human Services (2011) Determination that a demonstration needle exchange program would be effective in reducing drug abuse and the risk of acquired immune deficiency syndrome infection among intravenous drug users. Fed Regist 76:10038
Des Jarlais DC, Friedman SR, Sotheran JL, Stoneburner R (1988) The sharing of drug injection equipment and the AIDS epidemic in New York City: the first decade. NIDA Res Monogr 80:160–175
Des Jarlais DC, Perlis T, Arasteh K et al (2004) Informed altruism” and “partner restriction” in the reduction of HIV infection in injecting drug users entering detoxification treatment in New York City, 1990–2001. J Acquir Immune Defic Syndr 35:158–166
Des Jarlais DC, Arasteh K, McKnight C, Hagan H, Perlman DC, Torian LV, Beatice S, Semaan S, Friedman SR (2010) HIV infection during limited versus combined HIV prevention programs for IDUs in New York City: the importance of transmission behaviors. Drug Alcohol Depend 109:154–160
Doe-Simkins M, Walley AY, Epstein A, Moyer P (2009) Saved by the nose: bystander-administered intranasal naloxone hydrochloride for opioid overdose. Am J Pub Health 99:788–791
Dolan K, Rutter S, Wodak AD (2003) Prison-based syringe exchange programmes: a review of international research and development. Addiction (Abingdon, England) 98:153–158
Dolan K, Shearer J, White B, Zhou J, Kaldor J, Wodak AD (2005) Four-year follow-up of imprisoned male heroin users and methadone treatment: mortality, re-incarceration and hepatitis C infection. Addiction (Abingdon, England) 100:820–828
ECDC, EMCDDA (2011) Prevention and control of infectious diseases among people who inject drugs. ECDC and EMCDDA joint guidance. European Centre for Disease Prevention and Control, Stockholm
EMCDDA (2010) Problem amphetamine and methamphetamine use in Europe. Selected issue. Publications Office of the European Union, Luxembourg. http://www.emcdda.europa.eu/publications/selected-issues/problem-amphetamine. Accessed 17 Mar 2013
EMCDDA (2012) Annual report 2012: the state of the drugs problem in Europe. Publications Office of the European Union, Luxembourg. http://www.emcdda.europa.eu/publications/annual-report/2012. Accessed 17 Mar 2013
Faggiano F, Vigna-Taglianti F, Versino E, Lemma P (2003) Methadone maintenance at different dosages for opioid dependence. Cochrane Database Syst Rev (Online) CD002208
Fischer B, Powis J, Firestone Cruz M, Rudzinski K, Rehm J (2008) Hepatitis C virus transmission among oral crack users: viral detection on crack paraphernalia. Eur J Gastroenterol Hepatol 20:29–32
Gates S, Smith LA, Foxcroft DR (2006) Auricular acupuncture for cocaine dependence. Cochrane Database Syst Rev (Online) CD005192
Gowing L, Farrell M, Bornemann R, Ali R (2004) Substitution treatment of injecting opioid users for prevention of HIV infection. Cochrane Database Syst Rev (Online) CD004145
Gowing L, Farrell MF, Bornemann R, Sullivan LE, Ali R (2011) Oral substitution treatment of injecting opioid users for prevention of HIV infection. Cochrane Database Syst Rev (Online) CD004145
Grund JP, Broadhead R, Heckathorn D, Stern SL, Anthony DL (1996) Peer-driven outreach to combat HIV among IDUs: a basic design and preliminary results. In: Rhodes T, Hartnoll R (eds) AIDS, drugs and prevention: perspectives on individual and community action. Routledge, London, pp 201–215
Grund J, Coffin P, Jauffret-Roustide M, Dijkstra M, de Bruin D, Blanken P (2010) The fast and furious – cocaine, amphetamines and harm reduction. In: Rhodes T, Hedrich D (eds) Harm reduction: evidence, impacts and challenges. Publications Office of the European Union, Luxembourg, pp 191–232
Haasen C, Prinzleve M, Gossop M, Fischer G, Casas M (2005) Relationship between cocaine use and mental health problems in a sample of European cocaine powder or crack users. World Psychiatry: Off J World Psychiatr Assoc (WPA) 4:173–176
Hagan H, McGough JP, Thiede H, Hopkins S, Duchin J, Alexander ER (2000) Reduced injection frequency and increased entry and retention in drug treatment associated with needle-exchange participation in Seattle drug injectors. J Subst Abus Treat 19:247–252
Harm Reduction Coalition (2012) Overdose prevention and naloxone manual. http://harmreduction.org/wp-content/uploads/2012/11/od-manual-final-links.pdf. Accessed 20 Mar 2013
Hedrich D (2004) European report on drug consumption rooms. EMCDDA, Lisbon. http://www.emcdda.europa.eu/html.cfm/index54125EN.html. Accessed 21 Mar 2013
Hedrich D, Kerr T, Dubois-Arber F (2010) Drug consumption facilities in Europe and beyond. In: Rhodes T, Hedrich D (eds) Harm reduction: evidence, impacts and challenges. Publications Office of the European Union, Luxembourg, pp 305–331
Hedrich D, Alves P, Farrell M, Stöver H, Møller L, Mayet S (2012) The effectiveness of opioid maintenance treatment in prison settings: a systematic review. Addiction (Abingdon, England) 107:501–517
Islam MM, Conigrave KM (2007) Assessing the role of syringe dispensing machines and mobile van outlets in reaching hard-to-reach and high-risk groups of injecting drug users (IDUs): a review. Harm Reduction J 4:14
Jones L, Pickering L, Sumnall H, McVeigh J, Bellis MA (2008) A review of the effectiveness and cost-effectiveness of needle and syringe programmes for injecting drug users. Res Rep. http://www.nice.org.uk/nicemedia/live/12130/43372/43372.pdf. Accessed 20 Mar 2013
Kerr D, Kelly A-M, Dietze P, Jolley D, Barger B (2009) Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose. Addiction (Abingdon, England) 104:2067–2074
Kimber J, Palmateer N, Hutchinson S, Hickman M, Goldberg D, Rhodes T (2010) Harm reduction among injecting drug users – evidence of effectiveness. In: Rhodes T, Hedrich D (eds) Harm reduction: evidence, impacts and challenges. Publications Office of the European Union, Luxembourg, pp 115–164
Knapp WP, Soares BGO, Farrel M, Lima MS (2007) Psychosocial interventions for cocaine and psychostimulant amphetamines related disorders. Cochrane Database Syst Rev (Online) CD003023
Lagu T, Anderson BJ, Stein M (2006) Overdoses among friends: drug users are willing to administer naloxone to others. J Subst Abus Treat 30:129–133
Latkin CA, Forman V, Knowlton A, Sherman S (2003) Norms, social networks, and HIV-related risk behaviors among urban disadvantaged drug users. Soc Sci Med 56:465–476
Leonard L, DeRubeis E, Pelude L, Medd E, Birkett N, Seto J (2008) “I inject less as I have easier access to pipes”: injecting, and sharing of crack-smoking materials, decline as safer crack-smoking resources are distributed. Int J Drug Policy 19:255–264
MacArthur GJ, Minozzi S, Martin N, Vickerman P, Deren S, Bruneau J, Degenhardt L, Hickman M (2012) Opiate substitution treatment and HIV transmission in people who inject drugs: systematic review and meta-analysis. BMJ (Clin Res Ed) 345:e5945
Marshall BDL, Milloy M-J, Wood E, Montaner JSG, Kerr T (2011) Reduction in overdose mortality after the opening of North America’s first medically supervised safer injecting facility: a retrospective population-based study. Lancet 377:1429–1437
Mattick RP, Kimber J, Breen C, Davoli M (2008) Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev (Online) CD002207
Maxwell S, Bigg D, Stanczykiewicz K, Carlberg-Racich S (2006) Prescribing naloxone to actively injecting heroin users: a program to reduce heroin overdose deaths. J Addict Dis 25:89–96
Meader N, Li R, Des Jarlais DC, Pilling S (2010) Psychosocial interventions for reducing injection and sexual risk behaviour for preventing HIV in drug users. Cochrane Database Syst Rev (Online) CD007192
Meader N, Semaan S, Halton M, Bhatti H, Chan M, Llewellyn A, Des Jarlais DC (2013) An international systematic review and meta-analysis of multisession psychosocial interventions compared with educational or minimal interventions on the HIV sex risk behaviors of people who use drugs. AIDS Behav. doi:10.1007/s10461-012-0403-y
Needle RH, Coyle SL, Normand J, Lambert E, Cesari H (1998) HIV prevention with drug-using populations – current status and future prospects: introduction and overview. Pub Health Rep (Washington, DC: 1974) 113(Suppl):4–18
Needle RH, Burrows D, Friedman SR et al (2005) Effectiveness of community-based outreach in preventing HIV/AIDS among injecting drug users. Int J Drug Policy 16:45–57
NIDA (2000) An overview of the NIDA community-based outreach model. A manual to reduce the risk of HIV and other blood-borne infections in drug users. NIH Publication. http://archives.drugabuse.gov/CBOM/. Accessed 19 Mar 2013
NIDA (2006) Methadone research web guide. Part B: 20 questions and answers regarding methadone maintenance treatment research. Question 4. Online document. National Institute on Drug Abuse. http://international.drugabuse.gov/educational-opportunities/certificate-programs/methadone-research-web-guide/part-b/question-4-does-m. Accessed 7 Mar 2013
Palepu A, Tyndall MW, Joy R, Kerr T, Wood E, Press N, Hogg RS, Montaner JSG (2006) Antiretroviral adherence and HIV treatment outcomes among HIV/HCV co-infected injection drug users: the role of methadone maintenance therapy. Drug Alcohol Depend 84:188–194
Palmateer N, Kimber J, Hickman M, Hutchinson S, Rhodes T, Goldberg D (2010) Evidence for the effectiveness of sterile injecting equipment provision in preventing hepatitis C and human immunodeficiency virus transmission among injecting drug users: a review of reviews. Addiction (Abingdon, England) 105:844
Pizzey R, Hunt N (2008) Distributing foil from needle and syringe programmes (NSPs) to promote transitions from heroin injecting to chasing: an evaluation. Harm Reduction J 5:24
Pollini RA, McCall L, Mehta SH, Celentano DD, Vlahov D, Strathdee S (2006) Response to overdose among injection drug users. Am J Prev Med 31:261–264
Rhodes T, Hartnoll RL (1991) Reaching the hard to reach: models of HIV outreach health education. In: Aggleton P, Hart G, Davies P (eds) AIDS: responses, interventions and care. The Falmer Press, London, pp 233–248
Rhodes T, Hartnoll R (eds) (1996) AIDS, drugs and prevention: perspectives on individual and community action. Routledge, London/New York
Rhodes R, Hedrich D (eds) (2010) Harm reduction: evidence, impacts and challenges, EMCDDA scientific monograph series no. 10. Publications Office of the European Union, Luxembourg. http://www.emcdda.europa.eu/publications/monographs/harm-reduction. Accessed 17 Mar 2013
Rhodes T, Stoneman A, Hope V, Hunt N, Martin A, Judd A (2006) Groin injecting in the context of crack cocaine and homelessness: from “risk boundary” to “acceptable risk”? Int J Drug Policy 17:164–170
Ritter A, Cameron J (2006) A review of the efficacy and effectiveness of harm reduction strategies for alcohol, tobacco and illicit drugs. Drug Alcohol Rev 25:611–624
Rush CR, Stoops WW (2012) Agonist replacement therapy for cocaine dependence: a translational review. Future Med Chem 4:245–265
Semaan S, Des Jarlais DC, Sogolow E, Johnson WD, Hedges LV, Ramirez G, Flores SA, Norman L, Sweat MD, Needle R (2002) A meta-analysis of the effect of HIV prevention interventions on the sex behaviors of drug users in the United States. J Acquir Immune Defic Syndr 30(Suppl 1):S73–S93
Semaan S, Neumann MS, Hutchins K, D’Anna LH, Kamb ML (2010) Brief counseling for reducing sexual risk and bacterial STIs among drug users – results from project RESPECT. Drug Alcohol Depend 106:7–15
Shoptaw S, Reback CJ (2006) Associations between methamphetamine use and HIV among men who have sex with men: a model for guiding public policy. J Urban Health Bull N Y Acad Med 83:1151–1157
Small W, Kain S, Laliberte N, Schechter MT, O’Shaughnessy MV, Spittal PM (2005) Incarceration, addiction and harm reduction: inmates experience injecting drugs in prison. Subst Use Misuse 40:831–843
Sorensen JL, Copeland AL (2000) Drug abuse treatment as an HIV prevention strategy: a review. Drug Alcohol Depend 59:17–31
Stimson G, Des Jarlais DC, Ball A (1998) Drug injecting and HIV infection: global dimensions and local changes. University College of London Press, London
Stöver H, Nelles J (2003) Ten years of experience with needle and syringe exchange programmes in European prisons. Int J Drug Policy 14:437–444
Strang J, Manning V, Mayet S, Best D, Titherington E, Santana L, Offor E, Semmler C (2008) Overdose training and take-home naloxone for opiate users: prospective cohort study of impact on knowledge and attitudes and subsequent management of overdoses. Addiction (Abingdon, England) 103:1648–1657
Strang J, Groshkova T, Metrebian N (2012) New heroin-assisted treatment: recent evidence and current practices of supervised injectable heroin treatment in Europe and beyond, EMCDDA insights series no. 11. Publications Office of the European Union, Luxembourg
The National Centre for HIV Epidemiology and Clinical Research (2009) Return on investment in needle and syringe programs in Australia: report. http://www.health.gov.au/internet/main/publishing.nsf/content/needle-return-1-sum. Accessed 7 Mar 2013
Tilson H, Aramrattana A, Bozzette S, Falco M, Hammett TM, Kozlov AP, Lai S, Mahal A, Schottenfeld RS, Solomon S, Celentano DD (2006) Preventing HIV infection among injecting drug users in high risk countries: an assessment of the evidence. Committee on the prevention of HIV infection among injecting drug users in high-risk countries, Institute of Medicine, The National Academies Press, Washington, DC. http://www.nap.edu/catalog.php?record_id=11731#toc. Accessed 17 Mar 2013
Turner KME, Hutchinson S, Vickerman P et al (2011) The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence. Addiction (Abingdon, England) 106:1978–1988
van den Berg C, Smit C, Van Brussel G, Coutinho R, Prins M (2007) Full participation in harm reduction programmes is associated with decreased risk for human immunodeficiency virus and hepatitis C virus: evidence from the Amsterdam Cohort Studies among drug users. Addiction (Abingdon, England) 102:1454–1462
Walley AY, Xuan Z, Hackman HH, Quinn E, Doe-Simkins M, Sorensen-Alawad A, Ruiz S, Ozonoff A (2013) Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ 346:f174–f174
WHO (2004a) Effectiveness of sterile needle and syringe programming in reducing HIV/AIDS among IDUs, Evidence for action technical paper and policy brief. WHO, Geneva. http://www.who.int/hiv/pub/idu/e4a-needle/en/index.html. Accessed 5 Mar 2013
WHO (2004b) Effectiveness of community-based outreach in preventing HIV/AIDS among injecting drug users, Evidence for action paper. WHO, Geneva. http://www.who.int/hiv/pub/idu/idu/en/. Accessed 3 Mar 2013
WHO (2009) Guidelines for the psychosocially assisted pharmacological treatment of opioid dependence. WHO, Geneva. http://www.who.int/substance_abuse/publications/9789241547543/en/index.html. Accessed 3 Mar 2013
WHO (2010) Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: recommendations for a public health approach – 2010 version. WHO, Geneva. http://www.who.int/hiv/pub/mtct/antiretroviral2010/en/index.html. Accessed 3 Mar 2013
WHO (2012) Guidance on prevention of viral hepatitis B and C among people who inject drugs. WHO, Geneva. http://www.who.int/hiv/pub/guidelines/hepatitis/en/index.html. Accessed 3 Mar 2013
WHO, UNAIDS, UNODC (2007) Effectiveness of interventions to address HIV in prisons, Evidence for action technical paper. WHO, Geneva. http://whqlibdoc.who.int/publications/2007/9789241596190_eng.pdf. Accessed 3 Mar 2013
WHO, UNAIDS, UNODC (2013) Technical guide for countries to set targets for universal access to HIV prevention, treatment and care for injecting drug users, 2012 revision. World Health Organization, Geneva. http://www.who.int/hiv/pub/idu/targets_universal_access/en/index.html. Accessed 3 Mar 2013
Williamson A, Darke S, Ross J, Teesson M (2006) The association between cocaine use and short-term outcomes for the treatment of heroin dependence: findings from the Australian Treatment Outcome Study (ATOS). Drug Alcohol Rev 25:141–148
Wood E, Kerr T, Spittal PM, Small W, Tyndall MW, O’Shaughnessy MV, Schechter MT (2003) An external evaluation of a peer-run “unsanctioned” syringe exchange program. J Urban Health Bull N Y Acad Med 80:455–464
Wright NMJ, Tompkins CNE (2006) A review of the evidence for the effectiveness of primary prevention interventions for hepatitis C among injecting drug users. Harm Reduction J 3:27
Zule WA, Cross HE, Stover J, Pretorius C (2013) Are major reductions in new HIV infections possible with people who inject drugs? The case for low dead-space syringes in highly affected countries. The Int J Drug Policy 24:1–7
Further Reading
Centers for Disease Control and Prevention (CDC) (2012) Integrated prevention services for HIV infection, viral hepatitis, sexually transmitted diseases, and tuberculosis for persons who use drugs illicitly: summary guidance from CDC and the U.S. Department of Health and Human Services. MMWR 61(RR05):1–43. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6105a1.htm. Accessed 5 Mar 2013
ECDC, EMCDDA (2011) Prevention and control of infectious diseases among people who inject drugs, ECDC and EMCDDA joint guidance. European Centre for Disease Prevention and Control, Stockholm
Rhodes R, Hedrich D (eds) (2010) Harm reduction: evidence, impacts and challenges, EMCDDA scientific monograph series no. 10. Publications Office of the European Union, Luxembourg. http://www.emcdda.europa.eu/publications/monographs/harm-reduction. Accessed 17 Mar 2013
Tilson H, Aramrattana A, Bozzette S, Falco M, Hammett TM, Kozlov AP, Lai S, Mahal A, Schottenfeld R, Solomon RS, Celentano DD (2006) Preventing HIV infection among injecting drug users in high risk countries: an assessment of the evidence. Committee on the prevention of HIV infection among injecting drug users in high-risk countries, Institute of Medicine, The National Academies Press, Washington, DC. http://www.nap.edu/catalog.php?record_id=11731#toc Accessed 17 Mar 2013
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Italia
About this entry
Cite this entry
Hedrich, D., Hartnoll, R. (2015). Harm Reduction Interventions. In: el-Guebaly, N., Carrà, G., Galanter, M. (eds) Textbook of Addiction Treatment: International Perspectives. Springer, Milano. https://doi.org/10.1007/978-88-470-5322-9_133
Download citation
DOI: https://doi.org/10.1007/978-88-470-5322-9_133
Published:
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-5321-2
Online ISBN: 978-88-470-5322-9
eBook Packages: MedicineReference Module Medicine