Skip to main content

Attention Deficit/Hyperactivity Disorder and Substance Abuse

  • Reference work entry
  • First Online:
Textbook of Addiction Treatment: International Perspectives
  • 265 Accesses

Abstract

Although attention-deficit hyperactivity disorder (ADHD) has been increasingly diagnosed and treated in adult populations, adult ADHD in substance-dependent populations remains under-recognized. Converging data from epidemiologic and clinical samples show that adult ADHD is overrepresented among individuals with substance use disorders . This chapter provides information regarding the potential causes for this overrepresentation and factors that might lead to both under and overdiagnosis in individuals with substance use disorders, with attention paid to DSM-V criteria. While stimulants are considered a first-line treatment for adults with ADHD, it is less clear what the first-line pharmacologic or psychotherapeutic treatment approaches should be for adults with ADHD and co-occurring substance use disorders. Data collected from several clinical trials suggest that under closely monitored conditions, stimulants can be used safely to treat co-occurring ADHD and substance use disorders. However, the findings are mixed regarding the efficacy of both nonstimulants and stimulants in treating ADHD in this comorbid population. Taken together, the available published studies do provide some guidance on how to best approach this patient population. Future avenues of research are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 339.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Acosta MC, Manubay J, Levin FR (2008) Pediatric obesity: parallels with addiction and treatment recommendations. Harv Rev Psychiatry 16(2):80–96

    Article  PubMed Central  PubMed  Google Scholar 

  • Adler LA, Spencer TJ, Milton DR, Moore RJ, Michelson D (2005) Long-term, open-label study of the safety and efficacy of atomoxetine in adults with attention-deficit/hyperactivity disorder: an interim analysis. J Clin Psychiatry 66(3):294–299

    Article  CAS  PubMed  Google Scholar 

  • Adler LA, Spencer T, Faraone SV, Kessler RC, Howes MJ, Biederman J, Secnik K (2006) Validity of pilot adult ADHD Self-Report Scale (ASRS) to rate adult ADHD symptoms. Ann Clin Psychiatry 18(3):145–148

    Article  PubMed  Google Scholar 

  • Anderson AL, Reid MS, Li SH, Holmes T, Shemanski L, Slee A, Smith EV, Kahn R, Chiang N, Vocci F, Ciraulo D, Dackis C, Roache JD, Salloum IM, Somoza E, Urschel HC 3rd, Elkashef AM (2009) Modafinil for the treatment of cocaine dependence. Drug Alcohol Depend 104(1–2):133–139

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • ASAM (2009) Principles of addiction medicine, 4th edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Aviram RB, Rhum M, Levin FR (2001) Psychotherapy of adults with comorbid attention-deficit/hyperactivity disorder and psychoactive substance use disorder. J Psychother Pract Res 10(3):179–186

    CAS  PubMed Central  PubMed  Google Scholar 

  • Barkley RA, Biederman J (1997) Toward a broader definition of the age-of-onset criterion for attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36(9):1204–1210

    Article  CAS  PubMed  Google Scholar 

  • Bates ME, Bowden SC, Barry D (2002) Neurocognitive impairment associated with alcohol use disorders: implications for treatment. Exp Clin Psychopharmacol 10(3):193–212

    Article  CAS  PubMed  Google Scholar 

  • Becker K, El-Faddagh M, Schmidt MH, Esser G, Laucht M (2008) Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms. J Pediatr 152(2):263–269

    Article  CAS  PubMed  Google Scholar 

  • Berkson J (1946) Limitations of the application of fourfold table analysis to hospital data. Biometrics 2(3):47–53

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Mick E, Faraone SV (2000) Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry 157(5):816–818

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Mick E, Surman C, Doyle R, Hammerness P, Harpold T, Dunkel S, Dougherty M, Aleardi M, Spencer T (2006) A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry 59(9):829–835

    Article  CAS  PubMed  Google Scholar 

  • Biederman J, Petty CR, Monuteaux MC, Fried R, Byrne D, Mirto T, Spencer T, Wilens TE, Faraone SV (2010) Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control study. Am J Psychiatry 167(4):409–417

    Article  PubMed  Google Scholar 

  • Bright GM, Delphia B, Wildberger B (2007) Survey evaluation of the abuse potential of prescription stimulants among patients with ADHD. Presented at the 106th annual meeting of the American Psychiatric Association, San Diego, 19–24 May

    Google Scholar 

  • Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen CK, Huang YS, Sethna V, Taylor E, Chen W, Breen G, Asherson P (2006) A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63(1):74–81

    Article  CAS  PubMed  Google Scholar 

  • Brown TE (1996) The Brown deficit disorder scale. The Psychological Corporation, San Antonio

    Google Scholar 

  • Brunton LL, Chabner B, Knollman B (2011) Goodman and Gilman’s the pharmacological basis of therapeutics, 12th edn. McGraw-Hill, New York

    Google Scholar 

  • Budney AJ, Moore BA, Rocha HL, Higgins ST (2006) Clinical trial of abstinence-based vouchers and cognitive-behavioral therapy for cannabis dependence. J Consult Clin Psychol 74(2):307–316

    Article  PubMed  Google Scholar 

  • Carroll KM, Rounsaville BJ (1993) History and significance of childhood attention deficit disorder in treatment-seeking cocaine abusers. Compr Psychiatry 34(2):75–82

    Article  CAS  PubMed  Google Scholar 

  • Caspi A, Langley K, Milne B, Moffitt TE, O’Donovan M, Owen MJ, Polo Tomas M, Poulton R, Rutter M, Taylor A, Williams B, Thapar A (2008) A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 65(2):203–210

    Article  PubMed  Google Scholar 

  • Chang Z, Lichtenstein P, Larsson H (2012) The effects of childhood ADHD symptoms on early-onset substance use: a Swedish twin study. J Abnorm Child Psychol 40(3):425–435

    Article  PubMed  Google Scholar 

  • Clure C, Brady KT, Saladin ME, Johnson D, Waid R, Rittenbury M (1999) Attention-deficit/hyperactivity disorder and substance use: symptom pattern and drug choice. Am J Drug Alcohol Abuse 25(3):441–448

    Article  CAS  PubMed  Google Scholar 

  • Collins SL, Levin FR, Foltin RW, Kleber HD, Evans SM (2006) Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD. Drug Alcohol Depend 82(2):158–167

    Article  CAS  PubMed  Google Scholar 

  • Conners C, Erhardt JN, Sparrow E (1999) Conner’s Adult ADHD Rating Scale (CAARS). Multi-Health Systems, North Tonawanda

    Google Scholar 

  • Connor DF, Fletcher KE, Swanson JM (1999) A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 38(12):1551–1559

    Article  CAS  PubMed  Google Scholar 

  • Connor DF, Findling RL, Kollins SH, Sallee F, Lopez FA, Lyne A, Tremblay G (2012) Effects of guanfacine extended release on oppositional symptoms in children aged 6–12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trial. CNS Drugs 24(9):755–768

    Google Scholar 

  • Dackis CA, Lynch KG, Yu E, Samaha FF, Kampman KM, Cornish JW, Rowan A, Poole S, White L, O’Brien CP (2003) Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study. Drug Alcohol Depend 70(1):29–37

    Article  CAS  PubMed  Google Scholar 

  • Daigre C, Ramos-Quiroga JA, Valero S, Bosch R, Roncero C, Gonzalvo B, Nogueira M, Casas M (2009) Adult ADHD Self-Report Scale (ASRS-v1.1) symptom checklist in patients with substance use disorders. Actas Esp Psiquiatr 37(6):299–305

    Google Scholar 

  • Dakwar E, Mahony A, Pavlicova M, Glass A, Brooks DJ, Mariani JJ, Grabowski J (2012) The utility of ADHD screening instruments in individuals seeking treatment for substance use disorders. J Clin Psychiatry 73(11):1372–1378

    Google Scholar 

  • Daughton JM, Kratochvil CJ (2009) Review of ADHD pharmacotherapies: advantages, disadvantages, and clinical pearls. J Am Acad Child Adolesc Psychiatry 48(3):240–248

    Article  PubMed  Google Scholar 

  • DSM-5 (2013) American Psychiatric Association: diagnostic and statistical manual of mental disorders, 5th edition, DSM-5. American Psychiatric Association, Arlington

    Google Scholar 

  • Elkashef AM, Rawson RA, Anderson AL, Li SH, Holmes T, Smith EV, Chiang N, Kahn R, Vocci F, Ling W, Pearce VJ, McCann M, Campbell J, Gorodetzky C, Haning W, Carlton B, Mawhinney J, Weis D (2008) Bupropion for the treatment of methamphetamine dependence. Neuropsychopharmacology 33(5):1162–1170

    Article  CAS  PubMed  Google Scholar 

  • Elkins IJ, McGue M, Iacono WG (2007) Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. Arch Gen Psychiatry 64(10):1145–1152

    Article  PubMed  Google Scholar 

  • Epstein JN, Johnson DE, Conners CK (2001) Conner’s Adult ADHD Diagnostic Interview for DSM-IV (CAADID). Multi-Health Systems, North Tonawanda

    Google Scholar 

  • Faraone SV, Glatt SJ (2010) A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J Clin Psychiatry 71(6):754–763

    Article  PubMed  Google Scholar 

  • Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57(11):1313–1323

    Article  CAS  PubMed  Google Scholar 

  • Faraone SV, Biederman J, Spencer T, Mick E, Murray K, Petty C, Adamson JJ, Monuteaux MC (2006) Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid? Am J Psychiatry 163(10):1720–1729, quiz 1859

    Article  PubMed  Google Scholar 

  • Fayyad J, De Graaf R, Kessler R, Alonso J, Angermeyer M, Demyttenaere K, De Girolamo G, Haro JM, Karam EG, Lara C, Lepine JP, Ormel J, Posada-Villa J, Zaslavsky AM, Jin R (2007) Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry 190:402–409

    Article  CAS  PubMed  Google Scholar 

  • Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126(1):51–90

    Article  CAS  PubMed  Google Scholar 

  • Gordon M, Barkley RA, Lovett BJ (2006) Tests and observational measures. Attention-deficit hyperactivity disorder: handbook for diagnosis and treatment, Thirdth edn. Guilford Press, New York, pp 369–389

    Google Scholar 

  • Grabowski J, Rhoades H, Stotts A, Cowan K, Kopecky C, Dougherty A, Moeller FG, Hassan S, Schmitz J (2004) Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin dependence: two double-blind randomized clinical trials. Neuropsychopharmacology 29(5):969–981

    Article  CAS  PubMed  Google Scholar 

  • Grahman AW, Schultz TK, Mayo-Smith MF, Rios RK, Wilford BB (2003) Principles of addiction medicine, 3rd edn. American Society of Addiction Medicine, Chevy Chase

    Google Scholar 

  • Heil SH, Holmes HW, Bickel WK, Higgins ST, Badger GJ, Laws HF, Faries DE (2002) Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users. Drug Alcohol Depend 67(2):149–156

    Article  CAS  PubMed  Google Scholar 

  • Hien D, Matzner F, Frist MB, Spitzer RL, Williams JB, Gibbon M (2001) The structured clinical interview for DSM-IV, childhood version (KID-SCID). Department of Psychiatry, Columbia University Medical School, New York

    Google Scholar 

  • Higgins ST, Delaney DD, Budney AJ, Bickel WK, Hughes JR, Foerg F, Fenwick JW (1991) A behavioral approach to achieving initial cocaine abstinence. Am J Psychiatry 148(9):1218–1224

    Article  CAS  PubMed  Google Scholar 

  • Hodgkins P, Montejano L, Sasane R, Huse D (2011) Cost of illness and comorbidities in adults diagnosed with attention-deficit/hyperactivity disorder: a retrospective analysis. Prim Care Companion CNS Disord 13(2). pii: PCC.10m01030. doi:10.4088/PCC.10m01030

    Google Scholar 

  • Jardin B, Looby A, Earleywine M (2011) Characteristics of college students with attention-deficit hyperactivity disorder symptoms who misuse their medications. J Am Coll Health 59(5):373–377

    Article  PubMed  Google Scholar 

  • Jasinski DR, Kovacevic-Ristanovic R (2000) Evaluation of the abuse liability of modafinil and other drugs for excessive daytime sleepiness associated with narcolepsy. Clin Neuropharmacol 23(3):149–156

    Article  CAS  PubMed  Google Scholar 

  • Jasinski DR, Krishnan S (2009) Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse. J Psychopharmacol 23(4):419–427

    Article  CAS  PubMed  Google Scholar 

  • Jasinski DR, Faries DE, Moore RJ, Schuh LM, Allen AJ (2008) Abuse liability assessment of atomoxetine in a drug-abusing population. Drug Alcohol Depend 95(1–2):140–146

    Article  CAS  PubMed  Google Scholar 

  • Jensen PS, Arnold LE, Swanson JM, Vitiello B, Abikoff HB, Greenhill LL, Hechtman L, Hinshaw SP, Pelham WE, Wells KC, Conners CK, Elliott GR, Epstein JN, Hoza B, March JS, Molina BS, Newcorn JH, Severe JB, Wigal T, Gibbons RD, Hur K (2007) 3-year follow-up of the NIMH MTA study. J Am Acad Child Adolesc Psychiatry 46(8):989–1002

    Article  PubMed  Google Scholar 

  • Jerome L, Habinski L, Segal A (2006) Attention-deficit/hyperactivity disorder (ADHD) and driving risk: a review of the literature and a methodological critique. Curr Psychiatry Rep 8(5):416–426

    Article  PubMed  Google Scholar 

  • Kalbag AS, Levin FR (2005) Adult ADHD and substance abuse: diagnostic and treatment issues. Subst Use Misuse 40(13–14):1955–1981, 2043-8

    Article  PubMed  Google Scholar 

  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62(6):593–602

    Article  PubMed  Google Scholar 

  • Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM (2006) The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163(4):716–723

    Article  PubMed Central  PubMed  Google Scholar 

  • Kessler RC, Lane M, Stang PE, Van Brunt DL (2009) The prevalence and workplace costs of adult attention deficit hyperactivity disorder in a large manufacturing firm. Psychol Med 39(1):137–147

    Article  CAS  PubMed  Google Scholar 

  • Khantzian EJ (1983) An extreme case of cocaine dependence and marked improvement with methylphenidate treatment. Am J Psychiatry 140(6):784–785

    Article  CAS  PubMed  Google Scholar 

  • Khantzian EJ (1985) The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am J Psychiatry 142(11):1259–1264

    Article  CAS  PubMed  Google Scholar 

  • King VL, Brooner RK, Kidorf MS, Stoller KB, Mirsky AF (1999) Attention deficit hyperactivity disorder and treatment outcome in opioid abusers entering treatment. J Nerv Ment Dis 187(8):487–495

    Article  CAS  PubMed  Google Scholar 

  • Kollins SH, Rush CR, Pazzaglia PJ, Ali JA (1998) Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate. Exp Clin Psychopharmacol 6(4):367–374

    Article  CAS  PubMed  Google Scholar 

  • Konstenius M, Jayaram-Lindstrom N, Beck O, Franck J (2010) Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: a pilot study. Drug Alcohol Depend 108(1–2):130–133

    Article  CAS  PubMed  Google Scholar 

  • Kooij JJ, Huss M, Asherson P, Akehurst R, Beusterien K, French A, Sasane R, Hodgkins P (2012) Distinguishing comorbidity and successful management of adult ADHD. J Atten Disord 16(Suppl 5):3S–19S

    Article  PubMed  Google Scholar 

  • Kroutil LA, Van Brunt DL, Herman-Stahl MA, Heller DC, Bray RM, Penne MA (2006) Nonmedical use of prescription stimulants in the United States. Drug Alcohol Depend 84(2):135–143

    Article  PubMed  Google Scholar 

  • Langley K, Rice F, van den Bree MB, Thapar A (2005) Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review. Minerva Pediatr 57(6):359–371

    CAS  PubMed  Google Scholar 

  • Langley K, Heron J, O’Donovan MC, Owen MJ, Thapar A (2010) Genotype link with extreme antisocial behavior: the contribution of cognitive pathways. Arch Gen Psychiatry 67(12):1317–1323

    Article  PubMed  Google Scholar 

  • Levin FR, Evans SM, Kleber HD (1998) Prevalence of adult attention-deficit hyperactivity disorder among cocaine abusers seeking treatment. Drug Alcohol Depend 52(1):15–25

    Article  CAS  PubMed  Google Scholar 

  • Levin FR, Evans SM, Vosburg SK, Horton T, Brooks D, Ng J (2004) Impact of attention-deficit hyperactivity disorder and other psychopathology on treatment retention among cocaine abusers in a therapeutic community. Addict Behav 29(9):1875–1882

    Article  PubMed  Google Scholar 

  • Levin FR, Evans SM, Brooks DJ, Garawi F (2006a) Treatment of cocaine dependent treatment seekers with adult ADHD: double-blind comparison of methylphenidate and placebo. Drug Alcohol Depend 87(1):20–29

    Article  PubMed  CAS  Google Scholar 

  • Levin FR, Evans SM, Brooks DJ, Kalbag AS, Garawi F, Nunes EV (2006b) Treatment of methadone-maintained patients with adult ADHD: double-blind comparison of methylphenidate, bupropion and placebo. Drug Alcohol Depend 81(2):137–148

    Article  CAS  PubMed  Google Scholar 

  • Levin FR, Bisaga A, Raby W, Aharonovich E, Rubin E, Mariani J, Brooks DJ, Garawi F, Nunes EV (2007) Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence. J Subst Abuse Treat 34(1):80–89

    Article  PubMed Central  PubMed  Google Scholar 

  • Lichtenstein P, Carlstrom E, Rastam M, Gillberg C, Anckarsater H (2010) The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am J Psychiatry 167(11):1357–1363

    Article  PubMed  Google Scholar 

  • Lile JA, Stoops WW, Durell TM, Glaser PE, Rush CR (2006) Discriminative-stimulus, self-reported, performance, and cardiovascular effects of atomoxetine in methylphenidate-trained humans. Exp Clin Psychopharmacol 14(2):136–147

    Article  CAS  PubMed  Google Scholar 

  • Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, Kotimaa A, Moilanen I, Thomsen PH, Olsen J, Jarvelin MR (2003) Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry 160(6):1028–1040

    Article  PubMed  Google Scholar 

  • Mannuzza S, Klein RG (2000) Long-term prognosis in attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 9(3):711–726

    CAS  PubMed  Google Scholar 

  • Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M (1993) Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 50(7):565–576

    Article  CAS  PubMed  Google Scholar 

  • Mannuzza S, Klein RG, Bessler A, Malloy P, Hynes ME (1997) Educational and occupational outcome of hyperactive boys grown up. J Am Acad Child Adolesc Psychiatry 36(9):1222–1227

    Article  CAS  PubMed  Google Scholar 

  • Mariani JJ, Levin FR (2012) Psychostimulant treatment of cocaine dependence. Psychiatr Clin North Am 35(2):425–439

    Article  PubMed Central  PubMed  Google Scholar 

  • McRae-Clark AL, Carter RE, Killeen TK, Carpenter MJ, White KG, Brady KT (2010) A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder. Am J Addict 19(6):481–489

    Article  PubMed Central  PubMed  Google Scholar 

  • Michelson D, Adler L, Spencer T, Reimherr FW, West SA, Allen AJ, Kelsey D, Wernicke J, Dietrich A, Milton D (2003) Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies. Biol Psychiatry 53(2):112–120

    Article  CAS  PubMed  Google Scholar 

  • Mikami AY, Hinshaw SP, Patterson KA, Lee JC (2008) Eating pathology among adolescent girls with attention-deficit/hyperactivity disorder. J Abnorm Psychol 117(1):225–235

    Article  PubMed Central  PubMed  Google Scholar 

  • Miller NS, Gold MS (1998) Management of withdrawal syndromes and relapse prevention in drug and alcohol dependence. Am Fam Physician 58(1):139–146

    CAS  PubMed  Google Scholar 

  • Mooney ME, Herin DV, Schmitz JM, Moukaddam N, Green CE, Grabowski J (2009) Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial. Drug Alcohol Depend 101(1–2):34–41

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • MTA Study (1999) The MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56:1073–1086

    Article  Google Scholar 

  • Murphy KR, Barkley RA (1996) Prevalence of DSM-IV symptoms of ADHD in adult licensed drivers: implications of clinical diagnosis. J Atten Disord 1:147–161

    Article  Google Scholar 

  • Murphy KR, Gordon M (2006) Assessment of adults with ADHD. Attention-deficit hyperactivity disorder: handbook for diagnosis and treatment, 3rd edn. Guilford Press, New York, pp 425–450

    Google Scholar 

  • Nigg JT (2008) ADHD, lead exposure and prevention: how much lead or how much evidence is needed? Expert Rev Neurother 8(4):519–521

    Article  CAS  PubMed  Google Scholar 

  • Orvaschel H (1985) Psychiatric interviews suitable for use in research with children and adolescents. Psychopharmacol Bull 21(4):737–745

    CAS  PubMed  Google Scholar 

  • Pagoto SL, Curtin C, Lemon SC, Bandini LG, Schneider KL, Bodenlos JS, Ma Y (2009) Association between adult attention deficit/hyperactivity disorder and obesity in the US population. Obesity (Silver Spring) 17(3):539–544

    Article  Google Scholar 

  • Parasrampuria DA, Schoedel KA, Schuller R, Gu J, Ciccone P, Silber SA, Sellers EM (2007) Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans. J Clin Pharmacol 47(12):1476–1488

    Article  CAS  PubMed  Google Scholar 

  • Pope HG Jr, Gruber AJ, Hudson JI, Cohane G, Huestis MA, Yurgelun-Todd D (2003) Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug Alcohol Depend 69(3):303–310

    Article  PubMed  Google Scholar 

  • Rabiner DL, Anastopoulos AD, Costello EJ, Hoyle RH, McCabe SE, Swartzwelder HS (2009) The misuse and diversion of prescribed ADHD medications by college students. J Atten Disord 13(2):144–153

    Article  PubMed  Google Scholar 

  • Rasmussen P, Gillberg C (2000) Natural outcome of ADHD with developmental coordination disorder at age 22 years: a controlled, longitudinal, community-based study. J Am Acad Child Adolesc Psychiatry 39(11):1424–1431

    Article  CAS  PubMed  Google Scholar 

  • Riggs P, Winhusen TM (2009) Randomized controlled trial osmotic-release methylphenidate (OROS-MPH) attention deficit hyperactivity disorder in adolescents with substance use disorders. American Academy of Addiction Psychiatry 20th annual meeting, Los Angeles, 3–6 Dec

    Google Scholar 

  • Riggs PD, Hall SK, Mikulich-Gilbertson SK, Lohman M, Kayser A (2004) A randomized controlled trial of pemoline for attention-deficit/hyperactivity disorder in substance-abusing adolescents. J Am Acad Child Adolesc Psychiatry 43(4):420–429

    Article  PubMed  Google Scholar 

  • Riggs PD, Winhusen T, Davies RD, Leimberger JD, Mikulich-Gilbertson S, Klein C, Macdonald M, Lohman M, Bailey GL, Haynes L, Jaffee WB, Haminton N, Hodgkins C, Whitmore E, Trello-Rishel K, Tamm L, Acosta MC, Royer-Malvestuto C, Subramaniam G, Fishman M, Holmes BW, Kaye ME, Vargo MA, Woody GE, Nunes EV, Liu D (2011) Randomized controlled trial of osmotic-release methylphenidate with cognitive-behavioral therapy in adolescents with attention-deficit/hyperactivity disorder and substance use disorders. J Am Acad Child Adolesc Psychiatry 50(9):903–914

    Article  PubMed Central  PubMed  Google Scholar 

  • Rostain AL, Ramsay JR (2006) A combined treatment approach for adults with ADHD--results of an open study of 43 patients. J Atten Disord 10(2):150–159

    Article  PubMed  Google Scholar 

  • Rush CR, Stoops WW, Sevak RJ, Hays LR (2010) Cocaine choice in humans during D-amphetamine maintenance. J Clin Psychopharmacol 30(2):152–159

    Article  CAS  PubMed  Google Scholar 

  • Safren SA, Sprich S, Mimiaga MJ, Surman C, Knouse L, Groves M, Otto MW (2010) Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. JAMA 304(8):875–880

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Sagiv SK, Thurston SW, Bellinger DC, Tolbert PE, Altshul LM, Korrick SA (2010) Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. Am J Epidemiol 171(5):593–601

    Article  PubMed Central  PubMed  Google Scholar 

  • Sallee FR, Lyne A, Wigal T, McGough JJ (2009) Long-term safety and efficacy of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 19(3):215–226

    Article  PubMed  Google Scholar 

  • SAMHSA (2010) Office of Applied Studies. Results from the 2004 National Survey on Drug Use and Health. National Findings Substance Abuse and Mental Health Services Administration, Rockville

    Google Scholar 

  • Schubiner H, Saules KK, Arfken CL, Johanson CE, Schuster CR, Lockhart N, Edwards A, Donlin J, Pihlgren E (2002) Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence. Exp Clin Psychopharmacol 10(3):286–294

    Article  CAS  PubMed  Google Scholar 

  • Smith AK, Mick E, Faraone SV (2009) Advances in genetic studies of attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 11(2):143–148

    Article  PubMed  Google Scholar 

  • Somoza EC, Winhusen TM, Bridge TP, Rotrosen JP, Vanderburg DG, Harrer JM, Mezinskis JP, Montgomery MA, Ciraulo DA, Wulsin LR, Barrett JA (2004) An open-label pilot study of methylphenidate in the treatment of cocaine dependent patients with adult attention deficit/hyperactivity disorder. J Addict Dis 23(1):77–92

    Article  PubMed  Google Scholar 

  • Spencer TJ, Biederman J, Ciccone PE, Madras BK, Dougherty DD, Bonab AA, Livni E, Parasrampuria DA, Fischman AJ (2006) PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate. Am J Psychiatry 163(3):387–395

    Article  PubMed  Google Scholar 

  • Spencer TJ, Greenbaum M, Ginsberg LD, Murphy WR (2009) Safety and effectiveness of coadministration of guanfacine extended release and psychostimulants in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 19(5):501–510

    Article  PubMed Central  PubMed  Google Scholar 

  • Swanson JM, Greenhill LL, Lopez FA, Sedillo A, Earl CQ, Jiang JG, Biederman J (2006) Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation. J Clin Psychiatry 67(1):137–147

    Article  CAS  PubMed  Google Scholar 

  • Taylor FB, Russo J (2000) Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults. J Child Adolesc Psychopharmacol 10(4):311–320

    Article  CAS  PubMed  Google Scholar 

  • Taylor FB, Russo J (2001) Comparing guanfacine and dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder. J Clin Psychopharmacol 21(2):223–228

    Article  CAS  PubMed  Google Scholar 

  • Teter CJ, McCabe SE, Cranford JA, Boyd CJ, Guthrie SK (2005) Prevalence and motives for illicit use of prescription stimulants in an undergraduate student sample. J Am Coll Health 53(6):253–262

    Article  PubMed  Google Scholar 

  • Thapar A, Langley K, Asherson P, Gill M (2007) Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. Br J Psychiatry 190:1–3

    Article  PubMed  Google Scholar 

  • Thurstone C, Riggs PD, Salomonsen-Sautel S, Mikulich-Gilbertson SK (2010) Randomized, controlled trial of atomoxetine for attention-deficit/hyperactivity disorder in adolescents with substance use disorder. J Am Acad Child Adolesc Psychiatry 49(6):573–582

    PubMed Central  PubMed  Google Scholar 

  • Upadhyaya HP, Rose K, Wang W, O’Rourke K, Sullivan B, Deas D, Brady KT (2005) Attention-deficit/hyperactivity disorder, medication treatment, and substance use patterns among adolescents and young adults. J Child Adolesc Psychopharmacol 15(5):799–809

    Article  PubMed  Google Scholar 

  • van Emmerik-van Oortmerssen K, van de Glind G, van den Brink W, Smit F, Crunelle CL, Swets M, Schoevers RA (2012) Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis. Drug Alcohol Depend 122(1–2):11–19

    Article  PubMed  Google Scholar 

  • Vidal-Estrada R, Bosch-Munso R, Nogueira-Morais M, Casas-Brugue M, Ramos-Quiroga JA (2012) Psychological treatment of attention deficit hyperactivity disorder in adults: a systematic review. Actas Esp Psiquiatr 40(3):147–154

    PubMed  Google Scholar 

  • Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley JS, Dewey S, Ashby C, Liebermann J, Hitzemann R et al (1995) Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch Gen Psychiatry 52(6):456–463

    Article  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F, Baler R (2010) Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain’s control circuit. Bioessays 32(9):748–755

    Article  PubMed Central  PubMed  Google Scholar 

  • Ward MF, Wender PH, Reimherr FW (1993) The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 150(6):885–890

    Article  CAS  PubMed  Google Scholar 

  • Weiss RD, Griffin ML, Kolodziej ME, Greenfield SF, Najavits LM, Daley DC, Doreau HR, Hennen JA (2007) A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 164(1):100–107

    Article  PubMed  Google Scholar 

  • Wender PH, Reimherr FW, Wood D, Ward M (1985) A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type, in adults. Am J Psychiatry 142(5):547–552

    Article  CAS  PubMed  Google Scholar 

  • West SL, Mulsow M, Arredondo R (2003) Factor analysis of the Attention Deficit Scales for Adults (ADSA) with a clinical sample of outpatient substance abusers. Am J Addict 12(2):159–165

    Article  PubMed  Google Scholar 

  • White BP, Becker-Blease KA, Grace-Bishop K (2006) Stimulant medication use, misuse, and abuse in an undergraduate and graduate student sample. J Am Coll Health 54(5):261–268

    Article  PubMed  Google Scholar 

  • Wilens TE, Biederman J, Mick E (1998) Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict 7(2):156–163

    CAS  PubMed  Google Scholar 

  • Wilens TE, Monuteaux MC, Snyder LE, Moore H, Whitley J, Gignac M (2005) The clinical dilemma of using medications in substance-abusing adolescents and adults with attention-deficit/hyperactivity disorder: what does the literature tell us? J Child Adolesc Psychopharmacol 15(5):787–798

    Article  PubMed  Google Scholar 

  • Wilens TE, Gignac M, Swezey A, Monuteaux MC, Biederman J (2006) Characteristics of adolescents and young adults with ADHD who divert or misuse their prescribed medications. J Am Acad Child Adolesc Psychiatry 45(4):408–414

    Article  PubMed  Google Scholar 

  • Wilens TE, Adler LA, Adams J, Sgambati S, Rotrosen J, Sawtelle R, Utzinger L, Fusillo S (2008) Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Adolesc Psychiatry 47(1):21–31

    Article  PubMed  Google Scholar 

  • Winhusen TM, Somoza EC, Brigham GS, Liu DS, Green CA, Covey LS, Croghan IT, Adler LA, Weiss RD, Leimberger JD, Lewis DF, Dorer EM (2010) Impact of attention-deficit/hyperactivity disorder (ADHD) treatment on smoking cessation intervention in ADHD smokers: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 71(12):1680–1688

    Article  PubMed Central  PubMed  Google Scholar 

  • Wolraich ML, Wibbelsman CJ, Brown TE, Evans SW, Gotlieb EM, Knight JR, Ross EC, Shubiner HH, Wender EH, Wilens T (2005) Attention-deficit/hyperactivity disorder among adolescents: a review of the diagnosis, treatment, and clinical implications. Pediatrics 115(6):1734–1746

    Article  PubMed  Google Scholar 

  • Wu EQ, Birnbaum HG, Zhang HF, Ivanova JI, Yang E, Mallet D (2007) Health care costs of adults treated for attention-deficit/hyperactivity disorder who received alternative drug therapies. J Manag Care Pharm 13(7):561–569

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Frances R. Levin .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Italia

About this entry

Cite this entry

Levin, F.R. (2015). Attention Deficit/Hyperactivity Disorder and Substance Abuse. In: el-Guebaly, N., Carrà, G., Galanter, M. (eds) Textbook of Addiction Treatment: International Perspectives. Springer, Milano. https://doi.org/10.1007/978-88-470-5322-9_119

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-5322-9_119

  • Published:

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5321-2

  • Online ISBN: 978-88-470-5322-9

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics