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Crohn’s Disease

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Imaging of Perianal Inflammatory Diseases

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Abstract

Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory diseases of the gastrointestinal tract [1]. IBD cause significant gastrointestinal symptoms, among which are diarrhea, abdominal pain, bleeding, anemia, and weight loss. They are also associated with a spectrum of extraintestinal manifestations, such as arthritis, ankylosing spondylitis, sclerosing cholangitis, uveitis, iritis, pyoderma gangrenosum, and erythema nodosum.

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References

  1. Baumgart DC, Sandborn WJ (2007) Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369:1641–1657

    Article  PubMed  CAS  Google Scholar 

  2. Louis E, Collard A, Oger AF et al. (2001) Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut 49:777–782

    Article  PubMed  CAS  Google Scholar 

  3. Sandborn WJ, Fazio VW, Feagan BG et al. (2003) AGA technical review on perianal Crohn’s disease. Gastroenterology 125:1508–1530

    Article  PubMed  Google Scholar 

  4. Ardizzone S, Porro GB (2007) Perianal Crohn’s disease: overview. Dig Liver Dis 39:957–958

    Article  PubMed  CAS  Google Scholar 

  5. Tang LY, Rawsthorne P, Bernstein CN (2006) Are perineal and luminal fistulas associated in Crohn’s disease? A population-based study. Clin Gastroenterol Hepatol 4:1130–1134

    Article  PubMed  Google Scholar 

  6. Gasche C, Scholmerich J, Brynskov J et al. (2000) A simple classification of Crohn’s disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 6:8–15

    Article  PubMed  CAS  Google Scholar 

  7. Satsangi J, Silverberg MS, Vermeire S et al. (2006). The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 55:749–753

    Article  PubMed  CAS  Google Scholar 

  8. Vermeire S, Van Assche G, Rutgeerts P (2007) Perianal Crohn’s disease: classification and clinical evaluation. Dig Liver Dis 39: 959–962

    Article  PubMed  CAS  Google Scholar 

  9. Schwartz DA, Loftus EV Jr, Tremaine WJ et al. (2002). The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota. Gastroenterology 122:875–880

    Article  PubMed  Google Scholar 

  10. Ingle SB, Loftus EV Jr (2007). The natural history of perianal Crohn’s disease. Dig Liver Dis 39:963–969

    Article  PubMed  CAS  Google Scholar 

  11. Beaugerie L, Seksik P, Nion-Larmurier I et al. (2006) Predictors of Crohn’s disease. Gastroenterology 130:650–656

    Article  PubMed  Google Scholar 

  12. Schirbel A, Fiocchi C (2010) Inflammatory bowel disease: established and evolving considerations on its etiopathogenesis and therapy. J Dig Dis 11:266–276

    Article  PubMed  Google Scholar 

  13. Schwartz DA, Pemberton JH, Sandborn WJ (2001) Diagnosis and treatment of perianal fistulas in Crohn disease. Ann Intern Med 135:906–918

    PubMed  CAS  Google Scholar 

  14. Tozer PJ, Whelan K, Phillips RK et al. (2009) Etiology of perianal Crohn’s disease: role of genetic, microbiological, and immunological factors. Inflamm Bowel Dis 15:1591–1598

    Article  PubMed  Google Scholar 

  15. Present DH, Rutgeerts P, Targan S et al. (1999) Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med 340:1398–1405

    Article  PubMed  CAS  Google Scholar 

  16. Sandborn WJ, Present DH, Isaacs KL et al. (2003) Tacrolimus for the treatment of fistulas in patients with Crohn’s disease: a randomized, placebocontrolled trial. Gastroenterology 125:380–388

    Article  PubMed  CAS  Google Scholar 

  17. Ruffolo C, Citton M, Scarpa M et al. (2010) Perianal Crohn’s disease: is there something new? World J Gastroenterol 17:1939–46

    Article  Google Scholar 

  18. Van Assche G, Dignass A, Reinisch W et al. (2010) The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: special situations. J Crohns Colitis 4:63–101

    Article  PubMed  Google Scholar 

  19. Orlando A, Armuzzi A, Papi C et al. (2011) The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guidelines: the use of tumor necrosis factor-alpha antagonist therapy in inflammatory bowel disease. Dig Liver Dis 43:1–20

    Article  PubMed  Google Scholar 

  20. Thia KT, Mahadevan U, Feagan BG et al. (2009) Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn’s disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis 15:17–24

    Article  PubMed  Google Scholar 

  21. Dejaco C, Harrer M, Waldhoer T et al. (2003) Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn’s disease. Aliment Pharmacol Ther 18:1113–1120

    Article  PubMed  CAS  Google Scholar 

  22. West RL, van der Woude CJ, Hansen BE et al. (2004) Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn’s disease with infliximab: a double blind placebo-controlled study. Aliment Pharmacol Ther 20:1329–1336

    Article  PubMed  CAS  Google Scholar 

  23. Prefontaine E, MacDonald JK, Sutherland LR (2010) Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease. Cochrane Database of Systematic Reviews 6:CD000545

    Google Scholar 

  24. Soon SY, Ansari A, Yaneza M et al. (2004) Experience with the use of low-dose methotrexate for inflammatory bowel disease. Eur J Gastroenterol Hepatol 16:921–926

    Article  PubMed  CAS  Google Scholar 

  25. Sands BE, Anderson FH, Bernstein CN et al. (2004) Infliximab maintenance therapy for fis- tulizing Crohn’s disease. N Engl J Med 350:876–885

    Article  PubMed  CAS  Google Scholar 

  26. Hanauer SB, Sandborn WJ, Rutgeerts P et al. (2006) Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn’s disease: the CLASSIC-I trial. Gastroenterology 130: 323–333

    Article  PubMed  CAS  Google Scholar 

  27. Sandborn WJ, Feagan BG, Stoinov S et al. (2007) Certolizumab pegol for the treatment of Crohn’s disease. N Engl J Med 357:228–238

    Article  PubMed  CAS  Google Scholar 

  28. Schreiber S, Khaliq-Kareemi M, Lawrance IC et al. (2007) Maintenance therapy with certolizumab pegol for Crohn’s disease. N Engl J Med 357:239–250

    Article  PubMed  CAS  Google Scholar 

  29. Ng SC, Plamondon S, Gupta A et al. (2009) Prospective evaluation of anti-tumor necrosis factor therapy guided by magnetic resonance imaging for Crohn’s perineal fistulas. Am J Gastroenterol 104:2973–2986

    Article  PubMed  CAS  Google Scholar 

  30. Fukuda Y, Fujii H, Koganei K et al. (2008) Oral spherical adsorptive carbon for the treatment of intractable anal fistulas in Crohn’s disease: a multicenter, randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 103:1721–1729

    PubMed  Google Scholar 

  31. Moy J, Bodzin J (2006) Carbon dioxide laser ablation of perianal fistulas in patients with Crohn’s disease: experience with 27 patients. Am J Surg 191:424–427

    Article  PubMed  Google Scholar 

  32. Hammond TM, Grahn MF, Lunniss PJ (2004) Fibrin glue in the management of anal fistu- lae. Colorectal Dis 6:308–319

    Article  PubMed  CAS  Google Scholar 

  33. Vaughan D, Drumm B (1999) Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn’s disease. N Engl J Med 340:239–240

    Article  PubMed  CAS  Google Scholar 

  34. Peiro C, Rodríguez-Montes JA (2005) A phase I clinical trial of the treatment of Crohn’s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48:1416–1423

    Article  PubMed  Google Scholar 

  35. Garcia-Olmo D, Herreros D, Pascual I et al. (2009) Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum 52:79–86

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Gastroenterology Unit, Luigi Sacco University Hospital, Milan, Italy

    Andrea Cassinotti

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  1. Andrea Cassinotti
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Correspondence to Andrea Cassinotti .

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Editors and Affiliations

  1. Radiology Department, Luigi Sacco University Hospital, Milan, Italy

    Massimo Tonolini

  2. Gastroenterology Unit, Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy

    Giovanni Maconi

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Cassinotti, A. (2013). Crohn’s Disease. In: Tonolini, M., Maconi, G. (eds) Imaging of Perianal Inflammatory Diseases. Springer, Milano. https://doi.org/10.1007/978-88-470-2847-0_4

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  • DOI: https://doi.org/10.1007/978-88-470-2847-0_4

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2846-3

  • Online ISBN: 978-88-470-2847-0

  • eBook Packages: MedicineMedicine (R0)

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