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Normal Findings from Different Radiopharmaceuticals and Techniques, with Variants and Pitfalls

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Radionuclide Imaging of Infection and Inflammation

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Abstract

The pharmacokinetic and/or pharmacodynamic pattern of radiopharmaceuticals in patients may be affected by several factors including a variety of drugs, disease states and, in some cases, surgical procedure [1]. Among the factors that can change radiopharmaceutical biodistribution, co-administration of interfering drugs is the most commonly reported occurrence [2]. Drug-radiopharmaceutical interactions may arise as a result of the mode of drug action, of physico-chemical interactions between drugs and radiotracers, and of competition for common binding sites [2–4]. Table 1.1 lists drugs that can interfere with the biodistribution of 67Ga-citrate, radiolabeled leukocytes and [18F]FDG in patients [5].

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  1. Nuclear Medicine, Santa Maria Nuova Hospital IRCCS, Reggio Emilia, Italy

    Annibale Versari

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Versari, A. (2013). Normal Findings from Different Radiopharmaceuticals and Techniques, with Variants and Pitfalls. In: Radionuclide Imaging of Infection and Inflammation. Springer, Milano. https://doi.org/10.1007/978-88-470-2763-3_1

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