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Melatonin’s Beneficial Effects in Hepatic Injury

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Melatonin, Neuroprotective Agents and Antidepressant Therapy

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Abstract

Melatonin is not only synthesized in the pineal gland, but its synthesis has also been described in numerous peripheral organs such as the retina, bone marrow, skin, Harderian gland, platelets, lymphocytes, testes, and gastrointestinal tract. Melatonin also plays a role as a free radical scavenger being a highly effective antioxidant. Several studies have demonstrated the effect of melatonin as an antioxidant to clear off oxidative damage in toxic liver injury. Melatonin administration appears to lower the increase in serum enzyme levels of aspartate transaminase, alanine transaminase, lactate dehydrogenase, alkaline phosphatase, γ- glutamyl transferase, and bilirubin after almost all types of injury, denoting that the extent of cell damage was reduced. According to current evidences, it seems possible that the strong protective effects of melatonin are mediated by the melatonin receptors in the liver as the absence of melatonin receptors impedes the protective action of melatonin administration. However, more studies are needed to confirm these beneficial effects.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, 34303, Cerrahpaşa, Istanbul, Turkey

    Pınar Atukeren & Hafize Uzun PhD

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  1. Pınar Atukeren
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  2. Hafize Uzun PhD
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Correspondence to Hafize Uzun PhD .

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  1. Vice-Rectorate for Research and Sci, Camilo José Cela University Vice-Rectorate for Research and Sci, Madrid, Spain

    Francisco López-Muñoz

  2. International Medical Sciences Research Study Center, Sri Sathya Sai Medical Educational & Research Foundation, Coimbatore, India

    Venkataramanujam Srinivasan

  3. Department of Neurosciences and Ima, University of Chieti Department of Neurosciences and Ima, Italy, Italy

    Domenico de Berardis

  4. Department of Biomedical Sciences (Pharmacology Area), University of Alcalá, Madrid, Spain

    Cecilio Álamo

  5. Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan

    Takahiro A. Kato

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Atukeren, P., Uzun, H. (2016). Melatonin’s Beneficial Effects in Hepatic Injury. In: López-Muñoz, F., Srinivasan, V., de Berardis, D., Álamo, C., Kato, T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2803-5_13

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