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Stem Cell Therapy for Neurological Disorders: From Bench to Bedside

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Stem Cell Therapy for Organ Failure

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Abstract

According to the National Institute of Neurological Disorders and Stroke (NIH), there are found to be 488 neurological disorders present in the world at the time of writing, ranging from acid lipase disease to Zellweger syndrome [1]. No book chapter is equipped to tackle all of these in detail; however, it will focus upon the five major neurological diseases: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis. The chapter will begin by summarising the epidemiology, pathology and disease susceptibilities for each of these five major neurological diseases. The chapter will then look in detail at generating patient-specific cell lines for personalised medicine, genome editing and the differentiation protocols necessary for cell replacement therapy related to the aforementioned neurodegenerative diseases. This chapter will then look at the alternative cell sources that have been used as existing and current cell therapeutic strategies before summarising with the advantages and constraints of stem cells in research and clinical translation. Finally, the chapter will conclude on the current research findings with a particular focus on patient-derived research in Parkinson’s disease and how different therapeutic strategies can be targeted at different neurological diseases focusing on – Parkinson’s disease and multiple sclerosis – before summarising on the challenges for stem cell therapy in neurological disorders: from bench to the bedside.

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Authors and Affiliations

  1. Clinical and Experimental Neuroscience, School of Clinical Sciences, Université du Lukembourg, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1∼3NY, UK

    Peter A. Barbuti

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Correspondence to Peter A. Barbuti .

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  1. Department of Stem Cells and Regenerative Medicine, Centre for Interdisciplinary Research, DY Patil University, Kolhapur, Maharashtra, India

    Indumathi Somasundaram

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Barbuti, P.A. (2014). Stem Cell Therapy for Neurological Disorders: From Bench to Bedside. In: Somasundaram, I. (eds) Stem Cell Therapy for Organ Failure. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2110-4_4

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