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Phosphorylation of Drebrin and Its Role in Neuritogenesis

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Drebrin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1006))

Abstract

Neuritogenesis is an early event in neuronal development in which newborn neurons first form growth cones, as a prerequisite for the formation of axons and dendrites. Growth cones emerge from segmented regions of the lamellipodium of embryonic neurons and grow away from the cell body leaving behind a neurite that will eventually polarise into an axon or dendrite. Growth cones also function to navigate precise routes through the embryo to locate an appropriate synaptic partner. Dynamic interactions between two components of the neuronal cytoskeleton, actin filaments and microtubules, are known to be essential for growth cone formation and hence neuritogenesis. The molecular mechanisms that coordinate interactions between actin filaments and dynamic microtubules during neuritogenesis are beginning to be understood. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified.

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Authors and Affiliations

  1. MRC Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London, SE1 1UL, UK

    Phillip R. Gordon-Weeks

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  1. Phillip R. Gordon-Weeks
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Correspondence to Phillip R. Gordon-Weeks .

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Editors and Affiliations

  1. Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Tomoaki Shirao

  2. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

    Yuko Sekino

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Gordon-Weeks, P.R. (2017). Phosphorylation of Drebrin and Its Role in Neuritogenesis. In: Shirao, T., Sekino, Y. (eds) Drebrin. Advances in Experimental Medicine and Biology, vol 1006. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56550-5_4

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