Abstract
The skin is the largest organ in the body, and it is continuously exposed to external stimuli, such as chemical and environmental substances. Skin damage caused by contact with chemicals can be broadly classified according to the mechanism of onset. For example, contact dermatitis is damage resulting from contact with a substance (irritant dermatitis, allergic contact dermatitis, or chemical burns). This review outlines the structure of the skin and the characteristics of cutaneous damage caused by chemical contact. In recent years, advances have been made in the development of pharmaceutical products targeting specific molecules or genes and nanotechnology-based pharmaceutical products, raising concerns about the onset of toxicity by novel mechanisms involving new pharmaceutical products. Therefore, it is important to understand the basic toxicity-related changes described herein.
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Acknowledgements
This project was supported by a grant from MEXT-Supported Programs for the Strategic Research Foundations at Private Universities (Kansai Medical University). All authors have read and approved the final manuscript. The authors declare no competing financial interests.
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Yoshizawa, K., Kinoshita, Y., Takenouchi, A., Tsubura, A. (2017). Skin Damage Caused by Chemical Application. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_25
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DOI: https://doi.org/10.1007/978-4-431-56526-0_25
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