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Prevention and Treatment of Heart Failure Based on the Control of Inflammation

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Chronic Inflammation

Abstract

Heart failure is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. For decades, there have been three different concepts of heart failure and their corresponding treatment strategies: diuretics for volume retention, cardiotonics, vasodilators for abnormal hemodynamic state, neurohormonal antagonists for abnormalities in interorgan communication. These conventional treatments consistently prolongs survival in patients with heart failure but never cure the underlying heart diseases. Various risk factors induce heart injury and aortic damages, eventually leading to a final stage of cardiovascular disease, namely heart failure. It has become widely accepted that pathogenesis of heart injury and aortic damage is considered to be the result of a chronic inflammatory process. Therefore, chronic inflammation can be regarded as a new target that may treat and/or prevent heart failure. This chapter describes the recent advances in understanding of the mechanisms of chronic inflammation of cardiovascular diseases, especially focused on our accomplishments.

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Author information

Authors and Affiliations

  1. Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, Japan

    Motoaki Sano

  2. PRESTO, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan

    Motoaki Sano

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  1. Motoaki Sano
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Correspondence to Motoaki Sano .

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Editors and Affiliations

  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Sano, M. (2016). Prevention and Treatment of Heart Failure Based on the Control of Inflammation. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_52

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