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The Role of Innate Immunity in Ischemic Stroke

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Chronic Inflammation

Abstract

Inflammation is an essential step in the progression of ischemic stroke pathology. Various mechanisms of innate immunity are implicated in the acute sterile inflammation following ischemic brain injury. Ischemic insults induce the necrotic death of brain cells, which leads to the extracellular release of danger-associated molecular patterns (DAMPs). DAMPs are recognised by pattern recognition receptors (PRRs) in innate immune cells. IL-1β and various neurotoxic mediators are produced by the activation of PRRs. Caspase-1 activation and the formation of inflammasome complex are essential for the production of the active form of IL-1β in ischemic stroke. Recent evidence has supported the use of new therapeutic opportunities for ischemic stroke by targeting DAMPs and inflammasome. This review examines the evidence regarding the essential roles of innate immunity in the creation of novel treatments for ischemic stroke.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Takashi Shichita, Minako Ito, Rimpei Morita & Akihiko Yoshimura

  2. PRESTO, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan

    Takashi Shichita

Authors
  1. Takashi Shichita
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  2. Minako Ito
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  3. Rimpei Morita
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  4. Akihiko Yoshimura
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Correspondence to Takashi Shichita .

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Editors and Affiliations

  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Shichita, T., Ito, M., Morita, R., Yoshimura, A. (2016). The Role of Innate Immunity in Ischemic Stroke. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_49

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