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Cadherins in Neural Development

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The Cadherin Superfamily

Abstract

Cadherins play many diverse roles in the development of the nervous system of vertebrates. Far from being simple adhesion molecules, they also orchestrate cell generation, cell movements, and cell morphogenesis. Cadherins also regulate specificity of cell-to-cell interactions during neuronal circuit formation and function. Cadherin expression during neural development is also dynamic and highly regulated. At each phase of embryo development, cadherins emerge as key molecular determinants of neural function through their many diverse binding partners. Additionally, they play important roles in the plasticity of the nervous system, a key feature believed to underpin the ability of the brain to function. Many neurodevelopmental disorders also have cadherin disfunction at their heart indicating that cadherin-based therapies may emerge as future treatments for these devastating conditions.

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  1. Research Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK

    Lewis L. Brayshaw & Stephen R. Price

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  1. Department of Bioscience, Kwansei Gakuin University, Sanda, Hyogo, Japan

    Shintaro T. Suzuki

  2. Department of Cell Biology, Kansai Medical University, Hirakata, Osaka, Japan

    Shinji Hirano

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Brayshaw, L.L., Price, S.R. (2016). Cadherins in Neural Development. In: Suzuki, S., Hirano, S. (eds) The Cadherin Superfamily. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56033-3_12

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