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Introduction to Sympathetic Microneurography

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Clinical Assessment of the Autonomic Nervous System

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Abstract

Sympathetic microneurography is an electrophysiological method to record directly from human peripheral nerves’ sympathetic neural traffic leading to the muscle and skin called muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA). In this chapter, the author explains (1) what is microneurography, (2) the recording technique of microneurography, (3) how to identify MSNA and SSNA, and (4) applications of sympathetic microneurography. Sympathetic microneurography is very useful to analyze sympathetic neural functions in humans by observing directly neural traffic in postganglionic multiple and single sympathetic efferent fibers innervating the muscle and skin under physiological and pathological conditions. MSNA which regulates peripheral vascular resistance in skeletal muscles is particularly important for controlling blood pressure homeostasis, while SSNA which regulates mainly sweat glands and skin blood vessels plays important roles in thermoregulation. Recordings of MSNA and SSNA have been widely applied to analyze sympathetic mechanisms in various disease conditions, as well as stressful situations when the human body is exposed to various environmental conditions.

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References

  1. Hensel H, Boman KA. Afferent impulses in cutaneous sensory nerves in human subjects. J Neurophysiol. 1960;23:564–678.

    CAS  PubMed  Google Scholar 

  2. Knutsson E, Widén L. Impulses from single nerve fibers recorded in man using microelectrodes. Nature. 1967;213:606–7.

    Article  CAS  PubMed  Google Scholar 

  3. Hagbarth K-E, Vallbo ÅB. Mechanoreceptor activity recorded percutaneously with semi-microelectrodes in human peripheral nerves. Acta Physiol Scand. 1967;69:121–2.

    Article  CAS  PubMed  Google Scholar 

  4. Vallbo ÅB, Hagbarth K-E, Torebjök HE, Wallin G. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev. 1979;59:919–57.

    CAS  PubMed  Google Scholar 

  5. Mano T, Iwase S, Toma S. Microneurography as a tool in clinical neurophysiology to investigate peripheral neural traffic in humans. Clin Neurophysiol. 2006;117:2357–84.

    Article  PubMed  Google Scholar 

  6. Torebjök E, Hallin RG. Identification of afferent C units in intact human skin nerves. Brain Res. 1974;67:378–403.

    Google Scholar 

  7. Vallbo ÅB. Sensations evoked from the glabrous skin of the human hand by electrical stimulation of unitary mechanoreceptive afferents. Brain Res. 1981;29:359–63.

    Article  Google Scholar 

  8. Ochoa J, Torebjörk E. Sensation evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. J Physiol. 1989;415:583–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Simone DA, Marchettini P, Caputi G, Ochoa JL. Identification of muscle afferents subserving sensation of deep pain in humans. J Neurophysiol. 1994;72:883–9.

    CAS  PubMed  Google Scholar 

  10. Kunimoto M, Kirno K, Elam M, Wallin BG. Neuroeffector characteristics of sweat glands in the human hand activated by regular neural stimuli. J Physiol. 1991;442:391–411.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hagbarth K-E, Vallbo ÅB. Pulse and respiratory grouping of sympathetic impulses in human muscle nerves. Acta Physiol Scand. 1968;74:96–108.

    Article  CAS  PubMed  Google Scholar 

  12. Wallin BG. New aspects of sympathetic functions in man. In: Stålberg E, Young RR, editors. Butterworth international medical reviews, neurology 1, clinical neurophysiology. London: Butterworth; 1981. p. 145–67.

    Google Scholar 

  13. Wallin BG. Intraneural recording and autonomic function in man. In: Bannister R, editor. Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. Oxford: Oxford University Press; 1983. p. 36–51.

    Google Scholar 

  14. Mano T, Iwase S, Sugiyama Y. Double recording technique of sympathetic nerve traffic in microneurography. In: Kimura J, Shibasaki H, editors. Recent advances in clinical neurophysiology. Amsterdam: Elsevier Science BV; 1996. p. 416–9.

    Google Scholar 

  15. Macfield VG, Wallin BG, Vallbo ÅB. The discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves. J Physiol. 1994;481:799–899.

    Article  Google Scholar 

  16. Tsukahara R, Mano T. The recruitment pattern of single vasoconstrictor neurons in humans. J Auton Nerv Syst. 1997;66:26–34.

    Article  CAS  PubMed  Google Scholar 

  17. Nagasaka T, Hirata K, Mano T, Iwase S, Rossetti Y. Heat-induced finger vasoconstriction controlled by skin sympathetic nerve activity. J Appl Physiol. 1990;68:71–5.

    CAS  PubMed  Google Scholar 

  18. Kondo M, Iwase S, Mano T, Kuzuhara S. Direct measurement of human sympathetic nerve conduction velocity. Muscle Nerve. 2004;29:128–33.

    Article  PubMed  Google Scholar 

  19. Mano T. Clinical applications of microneurography. In: Robertson D, Biaggioni I, Burnstock G, Low PA, Paton JFR, editors. Primer on the autonomic nervous system. 3rd ed. Amsterdam: Elsevier and Academic Press; 2012. p. 393–7.

    Chapter  Google Scholar 

  20. Iwase S, Mano T, Watanabe Y, Saito M, Kobayashi F. Age-related changes of sympathetic outflow to muscles in humans. J Gerontol. 1991;46:M1–5.

    Article  CAS  PubMed  Google Scholar 

  21. Mano T. Muscular and cutaneous sympathetic nerve activity. In: Appenzeller O, editor. The autonomic nervous system(1), Handbook of clinical neurology, vol. 72. Amsterdam: Elsevier; 1999. p. 649–65.

    Google Scholar 

  22. Mano T. Microneurographic research on sympathetic nerve responses to environmental stimuli in humans. Jpn J Physiol. 1998;48:99–114.

    Article  CAS  PubMed  Google Scholar 

  23. Hornyak M, Cejnar M, Elam M, Hornyak M, Cejnar M, Elam M, Wallin BG. Sympathetic muscle nerve activity during sleep in man. Brain. 1991;114:1281–95.

    Article  PubMed  Google Scholar 

  24. Okada H, Iwase S, Mano T, Sugiyama Y, Watanabe T. Changes in muscle sympathetic nerve activity during sleep in humans. Neurology. 1991;41:1961–6.

    Article  CAS  PubMed  Google Scholar 

  25. Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T, et al. Influence of microgravity on astronauts’ sympathetic and vagal responses to Valsalva’s manoeuvre. J Physiol. 2002;544:253–64.

    Article  Google Scholar 

  26. Ertl AC, Dietrich A, Biaggioni I, Leine BD, Robertson RM, Cox JF, et al. Human sympathetic nerve activity and plasma noradrenaline kinetics in space. J Physiol. 2002;538:321–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Dietrich A, et al. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol. 2002;538:331–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF, et al. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J Physiol. 2002;544:653–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Gifu University of Medical Science, 795-1 Ichihiraga-Nagamine, Seki, Gifu, 501-3892, Japan

    Tadaaki Mano

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  1. Tadaaki Mano
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Correspondence to Tadaaki Mano .

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Editors and Affiliations

  1. Department of Phyisiology, Aichi Medical University, Nagakute, Aichi, Japan

    Satoshi Iwase

  2. Nagoya City University, Graduate School of Medical Science, Nagoya, Japan

    Junichiro Hayano

  3. Department of Neurology, Kanto Central Hospital, Tokyo, Tokyo, Japan

    Satoshi Orimo

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Mano, T. (2017). Introduction to Sympathetic Microneurography. In: Iwase, S., Hayano, J., Orimo, S. (eds) Clinical Assessment of the Autonomic Nervous System. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56012-8_1

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  • DOI: https://doi.org/10.1007/978-4-431-56012-8_1

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-56010-4

  • Online ISBN: 978-4-431-56012-8

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