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Cholinergic Pathology in Dementia with Lewy Bodies

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Dementia with Lewy Bodies

Abstract

Cholinergic dysfunction is a major feature of dementia with Lewy bodies (DLB) and makes a significant contribution to the cognitive impairment and other challenging symptoms seen in this condition. Despite this, or indeed, because of this, manipulation of the cholinergic system can offer significant therapeutic opportunities for treating DLB, and this is reflected in the fact that cholinesterase inhibitors remain one of our best treatments in this condition. In this chapter, we will explore the pathology of cholinergic dysfunction in DLB, review findings from both post-mortem and imaging studies and place this within a clinical framework.

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Authors and Affiliations

  1. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK

    John-Paul Taylor, Daniel Collerton, Fiona LeBeau & Elaine Perry

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  1. John-Paul Taylor
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  2. Daniel Collerton
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Correspondence to John-Paul Taylor .

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  1. Yokohama City University, Yokohama, Kanagawa, Japan

    Kenji Kosaka

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Taylor, JP., Collerton, D., LeBeau, F., Perry, E. (2017). Cholinergic Pathology in Dementia with Lewy Bodies. In: Kosaka, K. (eds) Dementia with Lewy Bodies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55948-1_3

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