Abstract
This chapter focuses on ventilatory response to hypercapnia (VRH) in patients with dementia with Lewy bodies (DLB). VRH is a rise in ventilation induced by increase in PCO2. In our study, VRH was impaired in all examined DLB patients, while that of Alzheimer’s disease (AD) and healthy elderly patients was normal. The mean VRH in DLB patients was significantly lower compared with Alzheimer’s disease and healthy elderly patients. Impaired VRH can be observed also in the prodromal and mild stages of DLB. Hypercapnia primarily stimulates the central chemoreceptors, putatively located in the medulla oblongata. Thus, impaired VRH may be, in part, associated with the DLB lesions in the medulla oblongata. VRH is a promising diagnostic method for differentiating DLB from AD. Furthermore, it is important to bear in mind that DLB patients are susceptible to respiratory compromise and have risk of poor outcome due to respiratory complications.
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Mizukami, K. (2017). Ventilatory Response to Hypercapnia in Dementia with Lewy Bodies. In: Kosaka, K. (eds) Dementia with Lewy Bodies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55948-1_15
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DOI: https://doi.org/10.1007/978-4-431-55948-1_15
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