Abstract
In order to investigate the neural pathway that controls motion of the vocal fold, we performed experiments using herpes simplex virus as a transsynaptic tracer. The tracer was injected into the mouse cricothyroid (CT) or thyroarytenoid/lateral cricoarytenoid (TA/LCA) muscles in order to assess projections to the nucleus ambiguus (NA). Labeled neurons were detected in the NA, nucleus retroambiguus (NRA), nucleus tractus solitarius (NTS), reticular nucleus, paratrigeminal nucleus, area postrema, and vestibular nucleus of the CT and TA/LCA groups. In addition, labeled neurons were detected in the cochlear nucleus of the TA/LCA group. We have therefore provided novel evidence for communication between the cochlear nucleus and the NA.
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References
Bieger D. Muscarinic activation of rhombencephalic neurones controlling oesophageal peristalsis in the rat. Neuropharmacology. 1984;23:1451–64.
Ross CA, Ruggiero DA, Reis DJ. Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla. J Comp Neurol. 1985;242:511–34.
Cunningham Jr ET, Sawchenko PE. A circumscribed projection from the nucleus of the solitary tract to the nucleus ambiguus in the rat: anatomical evidence for somatostatin-28-immunoreactive interneurons subserving reflex control of esophageal motility. J Neurosci. 1989;9:1668–82.
Hayakawa T, Takanaga A, Maeda S, Ito H, Seki M. Monosynaptic inputs from the nucleus tractus solitarii to the laryngeal motoneurons in the nucleus ambiguus of the rat. Anat Embryol (Berl). 2000;202:411–20.
Zhang SP, Bandler R, Davis PJ. Brain stem integration of vocalization: role of the nucleus retroambigualis. J Neurophysiol. 1995;74:2500–12.
Boers J, Klop EM, Hulshoff AC, de Weerd H, Holstege G. Direct projections from the nucleus retroambiguus to cricothyroid motoneurons in the cat. Neurosci Lett. 2002;319:5–8.
Arita H, Ichikawa K, Sakamoto M. Serotonergic cells in nucleus raphe pallidus provide tonic drive to posterior cricoarytenoid motoneurons via 5-hydroxytryptamine2 receptors in cats. Neurosci Lett. 1995;197:113–6.
Arita H, Kita I, Sakamoto M. Two distinct descending inputs to the cricothyroid motoneuron in the medulla originating from the amygdala and the lateral hypothalamic area. Adv Exp Med Biol. 1995;393:53–8.
Fay R, Gilbert KA, Lydic R. Pontomedullary neurons transsynaptically labeled by laryngeal pseudorabies virus. Neuroreport. 1993;5:141–4.
Barrett RT, Bao X, Miselis RR, Altschuler SM. Brain stem localization of rodent esophageal premotor neurons revealed by transneuronal passage of pseudorabies virus. Gastroenterology. 1994;107:728–37.
Bao X, Wiedner EB, Altschuler SM. Transsynaptic localization of pharyngeal premotor neurons in rat. Brain Res. 1995;696:246–9.
Waldbaum S, Hadziefendic S, Erokwu B, Zaidi SI, Haxhiu MA. CNS innervation of posterior cricoarytenoid muscles: a transneuronal labeling study. Respir Physiol. 2001;126:113–25.
Van Daele DJ, Cassell MD. Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle. Neuroscience. 2009;162:501–24.
Yamamoto M, Kurachi R, Morishima T, Kito J, Nishiyama Y. Immunohistochemical studies on the transneuronal spread of virulent herpes simplex virus type 2 and its US3 protein kinase-deficient mutant after ocular inoculation. Microbiol Immunol. 1996;40:289–94.
Siniaia MS, Miller AD. Vestibular effects on upper airway musculature. Brain Res. 1996;736:160–4.
Shiba K, Umezaki T, Zheng Y, Miller AD. The nucleus retroambigualis controls laryngeal muscle activity during vocalization in the cat. Exp Brain Res. 1997;115:513–9.
Holstege G. Anatomical study of the final common pathway for vocalization in the cat. J Comp Neurol. 1989;284:242–52.
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Mukudai, S., Sugiyama, Y., Hisa, Y. (2016). Central Projections to the Nucleus Ambiguus. In: Hisa, Y. (eds) Neuroanatomy and Neurophysiology of the Larynx. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55750-0_13
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DOI: https://doi.org/10.1007/978-4-431-55750-0_13
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