Abstract
IgG4-related disease (IgG4-RD) is a recently-described type systemic disease that affects many organs, including the pancreas, bile duct, salivary glands, aorta, retroperitoneum, and lungs. A few reports have described IgG4-RD of the prostate, urinary bladder, testes, and urethra. IgG4-RD is distinguished by common clinicopathological characteristics that extend across all organs involved. These common characteristics include lymphoplasmacytic infiltrate characterized by an abundance of IgG4-positive plasma cells, prominent fibrosis with a storiform pattern, mass forming lesions, and elevated serum IgG4 concentrations. These characteristics have also been observed in IgG4-RD of the prostate, urinary bladder, testes, and urethra. Patients who present with IgG4-RD of these organs may have lower urinary tract syndrome (LUTS), typified by dysuria, urine retention, and perhaps hematuria. However, patients with IgG4-RD affecting these organs can also be asymptomatic. IgG4-RD of the testes, which often presents as a painless mass, has frequently been observed in younger patients, posing a challenge in diagnosis.
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Uehara, T., Fujinaga, Y., Ogawa, T., Kawa, S. (2016). Other Urogenital Lesions (Testis, Paratesticular Lesion, Bladder, Prostate etc.). In: Saito, T., Stone, J., Nakashima, H., Saeki, T., Kawano, M. (eds) IgG4-Related Kidney Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55687-9_15
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DOI: https://doi.org/10.1007/978-4-431-55687-9_15
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