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Intraoperative Detection of Hepatocellular Carcinoma Using Indocyanine Green Fluorescence Imaging

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ICG Fluorescence Imaging and Navigation Surgery

Abstract

Indocyanine green (ICG)-based fluorescence imaging has been recently applied to liver surgery to detect hepatocellular carcinoma (HCC). This technique is quite safe and simple. Briefly, ICG is intravenously injected at a dose of 0.5 mg/kg body weight as a routine preoperative liver function test before surgery. On the day of surgery, after laparotomy, the liver surface is examined by a commercially available near-infrared (NIR) camera system with the surgical lights turned off. HCC nodules are usually detected as intense fluorescent signals by this method. In this chapter, we introduce the clinical applications of ICG fluorescence imaging in HCC surgery and review the clinical study literature to date. This technique is highly sensitive and complementary to conventional modalities for the detection of HCC. Although there are some limitations, such as the low penetration depth and the detection of false-positive lesions, this technique is expected to be indispensable for the diagnosis and treatment of HCC in the near future, with further developments in basic research and improvements of the devices.

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Acknowledgment

This work was supported in part by a grant from Osaka foundation for the prevention of cancer and cardiovascular diseases and by a grant from the Otsuka Research Fund.

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Authors and Affiliations

  1. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan

    Kunihito Gotoh, Shogo Kobayashi, Hirofumi Akita, Hidenori Takahashi, Masahiko Yano, Osamu Ishikawa & Masato Sakon

  2. Department of Surgery, Osaka University, Osaka, Japan

    Kunihito Gotoh & Shigeru Marubashi

  3. Department of Surgery, Higashiosaka City General Hospital, Osaka, Japan

    Terumasa Yamada

Authors
  1. Kunihito Gotoh
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  2. Shogo Kobayashi
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  3. Shigeru Marubashi
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  4. Terumasa Yamada
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  5. Hirofumi Akita
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  6. Hidenori Takahashi
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  7. Masahiko Yano
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  8. Osamu Ishikawa
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  9. Masato Sakon
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Corresponding author

Correspondence to Kunihito Gotoh .

Editor information

Editors and Affiliations

  1. Department of Surgery, Seiwa Memorial Hospital, Sapporo, Hokkaido, Japan

    Mitsuo Kusano

  2. Hepato-Biliary-Pancreatic Surgery Divisi, University of Tokyo, TOKYO 113-8655, Tokyo, Japan

    Norihiro Kokudo

  3. Department of Breast Surgery Graduate Sc, Kyoto University, Kyoto, Kyoto, Japan

    Masakazu Toi

  4. Department of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan

    Masaki Kaibori

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Gotoh, K. et al. (2016). Intraoperative Detection of Hepatocellular Carcinoma Using Indocyanine Green Fluorescence Imaging. In: Kusano, M., Kokudo, N., Toi, M., Kaibori, M. (eds) ICG Fluorescence Imaging and Navigation Surgery. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55528-5_29

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  • DOI: https://doi.org/10.1007/978-4-431-55528-5_29

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55527-8

  • Online ISBN: 978-4-431-55528-5

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