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Hantaviruses

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Abstract

This chapter focuses on hantaviruses of known human health importance. In humans, New World hantaviruses cause hantavirus pulmonary syndrome (HPS) and Old World hantaviruses cause hemorrhagic fever with renal syndrome (HFRS). Hantaviruses are distributed world-wide and are maintained primarily in rodent hosts.

Rodent hosts are persistently infected, transmitting the viruses among themselves, through fighting or contamination of their surroundings, the latter being the most frequent source of human infection. A variety of ecological factors influence the population dynamics of these rodent hosts and, in turn, the dynamics of transmission among them with corresponding risk of human infection.

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References

  • Alexeyev OA, Morozov VG (1995) Neurological manifestations of hemorrhagic fever with renal syndrome caused by Puumala virus: review of 811 cases. Clin Infect Dis 20(2):255–258

    CAS  PubMed  Google Scholar 

  • Amman BR, Manangan AP, Flietstra TD, Calisher CH, Carroll DS, Wagoner KD, Mills JN (2013) Association between movement and Sin Nombre virus (Bunyaviridae: Hantavirus) infection in North American deermice (Peromyscus maniculatus) in Colorado. J Wildl Dis 49(1):132–142

    PubMed  Google Scholar 

  • Armien B, Pascale JM, Muñoz C, Mariñas J, Núñez H, Herrera M, Trujillo J, Sánchez D, Mendoza Y, Hjelle B, Koster F (2013) Hantavirus fever without pulmonary syndrome in Panama. Am J Trop Med Hyg 89:489–494

    PubMed Central  PubMed  Google Scholar 

  • Armstrong LR, Zaki SR, Goldoft MJ, Todd RL, Khan AS, Khabbaz RF, Ksiazek TG, Peters CJ (1995) Hantavirus pulmonary syndrome associated with entering or cleaning rarely used, rodent-infested structures [letter]. J Infect Dis 172(4):1166

    CAS  PubMed  Google Scholar 

  • Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, Vandergroen G, Leduc JW (1992) Characterization of Dobrava virus: a hantavirus from Slovenia, Yugoslavia. J Med Virol 38:132–137

    CAS  PubMed  Google Scholar 

  • Avsic-Zupanc T, Nemirov K, Petrovec M, Trilar T, Poljak M, Vaheri A, Plyusnin A (2000) Genetic analysis of wild-type Dobrava hantavirus in Slovenia: co-existence of two distinct genetic lineages within the same natural focus. J Gen Virol 81(7):1747–1755

    CAS  PubMed  Google Scholar 

  • Baek LJ, Kariwa H, Lokugamage K, Yoshimatsu K, Arikawa J, Takashima I, Kang JI, Moon SS, Chung SY, Kim EJ et al (2006) Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea. J Med Virol 78(2):290–297

    CAS  PubMed  Google Scholar 

  • Bagamian KH, Towner JS, Kuenzi AJ, Douglass RJ, Rollin PE, Waller LA, Mills JN (2012) Transmission ecology of Sin Nombre hantavirus in naturally infected North American deermouse populations in outdoor enclosures. PLoS One 7(10):e47731

    CAS  PubMed Central  PubMed  Google Scholar 

  • Beers MH, Berkow R (2005) Infectious diseases; viral diseases. The merck manual of diagnosis and therapy, 17th edn. Wiley, Indianapolis

    Google Scholar 

  • Bernshtein AD, Apekina NS, Mikhailova TV, Myasnikov YA, Khlyap LA, Korotkov YS, Gavrilovskaya IN (1999) Dynamics of Puumala hantavirus infection in naturally infected bank voles (Clethrinomys glareolus). Arch Virol 144(12):2415–2428

    CAS  PubMed  Google Scholar 

  • Bi P, Wu X, Zhang F, Parton KA, Tong S (1998) Seasonal rainfall variability, the incidence of hemorrhagic fever with renal syndrome, and prediction of the disease in low-lying areas of China. Am J Epidemiol 148(3):276–281

    CAS  PubMed  Google Scholar 

  • Bi Z, Formenty PB, Roth CE (2008) Hantavirus infection: a review and global update. J Infect Dev Ctries 2(1):3–23

    PubMed  Google Scholar 

  • Boone JD, Mcgwire KC, Otteson EW, Debaca RS, Kuhn EA, Villard P, Brussard PF, St Jeor SC (2000) Remote sensing and geographic information systems: charting Sin Nombre virus infections in deer mice. Emerg Infect Dis 6(3):248–258

    CAS  PubMed Central  PubMed  Google Scholar 

  • Borges AA, Campos GM, Moreli ML, Souza RL, Aquino VH, Saggioro FP, Figueiredo LT (2006) Hantavirus cardiopulmonary syndrome: immune response and pathogenesis. Microbes Infect 8(8):2324–2330

    CAS  PubMed  Google Scholar 

  • Borges AA, Campos GM, Moreli ML, Moro Souza RL, Saggioro FP, Figueiredo GG, Livonesi MC, Moraes Figueiredo LT (2008) Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome. Microbes Infect 10(10–11):1150–1157

    CAS  PubMed  Google Scholar 

  • Botten J, Mirowsky K, Kusewitt D, Bharadwaj M, Yee J, Ricci R, Fedderson RM, Hjelle B (2000) Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus). Proc Natl Acad Sci U S A Biol Sci 97(19):10578–10583

    CAS  Google Scholar 

  • Botten J, Mirowsky K, Ye C, Gottlieb K, Saavedra M, Ponce L, Hjelle B (2002) Shedding and intracage transmission of Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus) model. J Virol 76(15):7587–7594

    CAS  PubMed Central  PubMed  Google Scholar 

  • Brummer-Korvenkontio M, Vaheri A, Hovi T, Von Bonsdorff CH, Vuorimies J, Manni T, Penttinen K, Oker-Blom N, Lähdevirta J (1980) Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis 141:131–134

    CAS  PubMed  Google Scholar 

  • Calisher CH, Sweeney W, Mills JN, Beaty BJ (1999) Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis 5(1):126–134

    CAS  PubMed Central  PubMed  Google Scholar 

  • Calisher CH, Root JJ, Mills JN, Beaty BJ (2002) Assessment of ecologic and biologic factors leading to hantavirus pulmonary syndrome, Colorado, U.S.A. Croat Med J 43(3):330–337

    PubMed  Google Scholar 

  • CDC (1997) Case definitions for infectious conditions under public health surveillance. Centers for disease control and prevention. MMWR Recomm Rep 46(RR-10):1–55

    Google Scholar 

  • CDC (2013a) Hantavirus. http://www.cdc.gov/hantavirus. Accessed 20 May 2013

  • CDC (2013b) Hemorrhagic fever with renal syndrome. http://www.cdc.gov/hantavirus/hfrs/index.html. Accessed 15 June 2013

  • CDC (2014) Reported cases of HPS. http://www.cdc.gov/hantavirus/surveillance/index.html. Accessed 14 August 2014

  • Chapman LE, Khabbaz RF (1994) Etiology and epidemiology of the Four Corners hantavirus outbreak. Infect Agents Dis 3(5):234–244

    CAS  PubMed  Google Scholar 

  • Chapman LE, Mertz GJ, Peters CJ, Jolson HM, Khan AS, Ksiazek TG, Koster FT, Baum KF, Rollin PE, Pavia AT et al (1999) Intravenous ribavirin for hantavirus pulmonary syndrome: a safety and tolerance during 1 year of open-label experience. Antivir Ther 4:211–219

    CAS  PubMed  Google Scholar 

  • Chen H-X, Qiu F-X, Dong B-J, Ji S-Z, Li Y-T, Wang Y et al (1986) Epiedmiologic studies on hemorrhagic fever with renal syndrome in China. J Infect Dis 154:394–398

    CAS  PubMed  Google Scholar 

  • Childs JE, Ksiazek TG, Spiropoulou CF, Krebs JW, Morzunov S, Maupin GO, Rollin PE, Sarisky J, Enscore RE, Frey JK et al (1994) Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169:1271–1280

    CAS  PubMed  Google Scholar 

  • Cho HW, Howard CR (1999) Antibody responses in humans to an inactivated hantavirus vaccine (Hantavax). Vaccine 17(20–21):2569–2575

    CAS  PubMed  Google Scholar 

  • Cho HW, Howard CR, Lee HW (2002) Review of an inactivated vaccine against hantaviruses. Intervirology 45:328–333

    CAS  PubMed  Google Scholar 

  • Clay CA, Lehmer EM, St Jeor S, Dearing MD (2009) Sin Nombre virus and rodent species diversity: a test of the dilution and amplification hypotheses. PLoS One 4:e6467

    PubMed Central  PubMed  Google Scholar 

  • Clement J, Vercauteren J, Verstraeten WW, Ducoffre G, Barrios JM, Vandamme AM, Maes P, Van RM (2009) Relating increasing hantavirus incidences to the changing climate: the mast connection. Int J Health Geogr 8:1

    PubMed Central  PubMed  Google Scholar 

  • Cosgriff TM (1991) Mechanisms of disease in hantavirus infection: pathophysiology of hemorrhagic fever with renal syndrome. Rev Infect Dis 13(1):97–107

    CAS  PubMed  Google Scholar 

  • Cruz CD, Forshey BM, Vallejo E, Agudo R, Vargas J, Blazes DL, Guevara C, Laguna-Torres VA, Halsey ES, Kochel TJ (2012) Novel strain of Andes virus associated with fatal human infection, central Bolivia. Emerg Infect Dis 18(5):750–757

    PubMed Central  PubMed  Google Scholar 

  • Cueto GR, Cavia R, Bellomo C, Padula PJ, Suarez OV (2008) Prevalence of hantavirus infection in wild Rattus norvegicus and R. rattus populations of Buenos Aires City, Argentina. Trop Med Int Health 13(1):46–51

    PubMed  Google Scholar 

  • Custer DM, Thompson E, Schmaljohn CS, Ksiazek TG, Hooper JW (2003) Active and passive vaccination against hantavirus pulmonary syndrome with Andes virus M genome segment-based DNA vaccine. J Virol 77(18):9894–9905

    CAS  PubMed Central  PubMed  Google Scholar 

  • Dahlberg KA (1992) The conservation of biological diversity and U.S. agriculture: goals, institutions, and policies. Agric Ecosyst Environ 42:177–193

    Google Scholar 

  • Delfraro A, Clara M, Tome L, Achaval F, Levis S, Calderón GE, Enría D, Lozano M, Russi J, Arbiza J (2003) Yellow pygmy rice rat (Oligoryzomys flavescens) and hantavirus pulmonary syndrome in Uruguay. Emerg Infect Dis 9(7):846–852

    PubMed Central  PubMed  Google Scholar 

  • Delfraro A, Tome L, D’elia G, Clara M, Achaval F, Russi JC, Rodonz JR (2008) Juquitiba-like hantavirus from 2 nonrelated rodent species, Uruguay. Emerg Infect Dis 14(9):1447–1451

    PubMed Central  PubMed  Google Scholar 

  • Douglass RJ, Wilson T, Semmens WJ, Zanto SN, Bond CW, Van Horn RC, Mills JN (2001) Longitudinal studies of Sin Nombre virus in deer mouse dominated ecosystems of Montana. Am J Trop Med Hyg 65(1):33–41

    CAS  PubMed  Google Scholar 

  • Douglass RJ, Calisher CH, Wagoner KD, Mills JN (2007) Sin Nombre virus infection of deer mice in Montana: characteristics of newly infected mice, incidence, and temporal pattern of infection. J Wildl Dis 43(1):12–22

    PubMed  Google Scholar 

  • Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR, Rollin PE, Nichol S, Umland ET, Group HS (1994) Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. New Engl J Med 330:949–955

    CAS  PubMed  Google Scholar 

  • Elgh F, Lundkvist A, Alexeyev OA, Stenlund H, Vsic-Zupanc T, Hjelle B, Lee HW, Smith KJ, Vainionpaa R, Wiger D et al (1997) Serological diagnosis of hantavirus infections by an enzyme-linked immunosorbent assay based on detection of immunoglobulin G and M responses to recombinant nucleocapsid proteins to five viral serotypes. J Clin Microbiol 35(5):1122–1130

    CAS  PubMed Central  PubMed  Google Scholar 

  • Elwell MR, Ward GS, Tingpalapong M, Leduc JW (1985) Serologic evidence of Hantaan-like virus in rodents and man in Thailand. Southeast Asian J Trop Med Public Health 16:349–354

    CAS  PubMed  Google Scholar 

  • Engelthaler DM, Mosley DG, Cheek JE, Levy CE, Komatsu KK, Ettestad P, Davis T, Tanda DT, Miller L, Frampton JW et al (1999) Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners region, United States. Emerg Infect Dis 5(1):87–94

    CAS  PubMed Central  PubMed  Google Scholar 

  • Enria D, Padula P, Segura EL, Pini N, Edelstein A, Posse CR, Weissenbacher MC (1996) Hantavirus pulmonary syndrome in Argentina Possibility of person to person transmission. Medicina (B Aires) 56:709–711

    CAS  Google Scholar 

  • Escutenaire S, Chalon P, De Jaegere F, Karelle-Bui L, Mees G, Brochier B, Rozenfeld F, Pastoret PP (2002) Behavioral, physiologic, and habitat influences on the dynamics of Puumala virus infection in bank voles (Clethrionomys glareolus). Emerg Infect Dis 8:930–936

    PubMed Central  PubMed  Google Scholar 

  • Evander M, Eriksson I, Pettersson L, Juto P, Ahlm C, Olsson GE, Bucht G, Allard A (2007) Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. J Clin Microbiol 45(8):2491–2497

    CAS  PubMed Central  PubMed  Google Scholar 

  • Firth C, Tokarz R, Simith DB, Nunes MR, Bhat M, Rosa ES, Medeiros DB, Palacios G, Vasconcelos PF, Lipkin WI (2012) Diversity and distribution of hantaviruses in South America. J Virol 86(24):13756–13766

    CAS  PubMed Central  PubMed  Google Scholar 

  • French G, Foulke R, Brand O, Eddy G (1981) Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin. Science 211:1046–1048

    CAS  PubMed  Google Scholar 

  • Gallardo MH, Mercado CL (1999) Mast seeding of bamboo shrubs and mouse outbreaks in southern Chile. Mastozool Neotrop 6:103–111

    Google Scholar 

  • Gavrilovskaya I, Gorbunova E, Koster F, Mackow E (2012) Elevated VEGF levels in pulmonary edema fluid and PBMCs from patients with acute hantavirus pulmonary syndrome. Adv Virol 2012:674360

    PubMed Central  PubMed  Google Scholar 

  • Giebel LB, Zoller L, Bautz EKF, Darai G (1990) Rapid detection of genomic variations in different strains of hantaviruses by polymerase chain reaction techniques and nucleotide sequence analysis. Virus Res 16:127–136

    CAS  PubMed  Google Scholar 

  • Gizzi M, Delaere B, Weynand B, Clement J, Maes P, Vergote V, Laenen L, Hjelle B, Verroken A, Dive A, Michaux I, Evrard P, Creytens D (2013) Bulpa P (2013) Another case of “European hantavirus pulmonary syndrome” with severe lung, prior to kidney, involvement, and diagnosed by viral inclusions in lung macrophages. Eur J Clin Microbiol Infect Dis 32:1341–1345

    CAS  PubMed  Google Scholar 

  • Glass GE, Childs JE, Korch GW, Leduc JW (1988) Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect 101:459–472

    CAS  PubMed Central  PubMed  Google Scholar 

  • Glass GE, Cheek JE, Patz JA, Shields TM, Doyle TJ, Thoroughman DA, Hunt DK, Enscore RE, Gage KL, Irland C et al (2000) Using remotely sensed data to identify areas at risk for hantavirus pulmonary syndrome. Emerg Infect Dis 6(3):238–247

    CAS  PubMed Central  PubMed  Google Scholar 

  • Glass GE, Yates TL, Fine JB, Shields TM, Kendall JB, Hope AG, Parmenter CA, Peters CJ, Ksiazek TG, Li CS et al (2002) Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States. Proc Natl Acad Sci U S A 99(26):16817–16822

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gligic A, Dimkovic N, Xiao SY, Buckle GJ, Jovanovic D, Velimirovic D, Stojanovic R, Obradovic M, Diglisic G, Micic J et al (1992) Belgrade virus: a new hantavirus causing severe hemorrhagic fever with renal syndrome in Yugoslavia. J Infect Dis 166:113–120

    CAS  PubMed  Google Scholar 

  • Hang CS, Song G, Qiu XZ, Du YL, Zhao JN, Liao HX et al (1982) Investigation of the agent causing mild type of hemorrhagic fever [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi 3:204–205

    CAS  PubMed  Google Scholar 

  • Hardestam J, Karlsson M, Falk KI, Olsson G, Klingstrom J, Lundkvist A (2008) Puumala hantavirus excretion kinetics in bank voles (Myodes glareolus). Emerg Infect Dis 14(8):1209–1215

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hepojoki J, Strandin T, Lankinen H, Vaheri A (2012) Hantavirus structure–molecular interactions behind the scene. J Gen Virol 93(Pt 8):1631–1644

    CAS  PubMed  Google Scholar 

  • Heyman P, Vaheri A, Lundkvist A, Vsic-Zupanc T (2009) Hantavirus infections in Europe: from virus carriers to a major public-health problem. Expert Rev Anti Infect Ther 7(2):205–217

    PubMed  Google Scholar 

  • Hickling R, Roy DB, Hill JK, Fox R, Thomas CD (2006) The distributions of a wide range of taxonomic groups are expanding polewards. Glob Change Biol 12(3):450–455

    Google Scholar 

  • Hinson ER, Shone SM, Zink MC, Glass GE, Klein SL (2004) Wounding: the primary mode of Seoul virus transmission among male Norway rats. Am J Trop Med Hyg 70(3):310–317

    PubMed  Google Scholar 

  • Hjelle B, Glass GE (2000) Outbreak of hantavirus infection in the Four Corners region of the United States in the wake of the 1997–1998 El Niño-Southern oscillation. J Infect Dis 181(5):1569–1573

    CAS  PubMed  Google Scholar 

  • Hjelle B, Jenison S, Torrez-Martinez N, Yamada T, Nolte K, Zumwalt R, Myers G (1994) A novel hantavirus associated with an outbreak of fatal respiratory disease in the southwestern United States: evolutionary relationships to known hantaviruses. J Virol 68:592–596

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hjelle B, Krolikowski J, Torrez-Martinez N, Chavez-Giles F, Vanner C, Laposata E (1995) Phylogenetically distinct hantavirus implicated in a case of hantavirus pulmonary syndrome in the northeastern United States. J Med Virol 46(1):21–27

    CAS  PubMed  Google Scholar 

  • Hjelle B, Torrez-Martinez N, Koster FT (1996) Hantavirus pulmonary syndrome-related virus from Bolivia [letter]. Lancet 347:57

    CAS  PubMed  Google Scholar 

  • Hjelle B, Jenison S, Torrez-Martinez N, Herring B, Quan S, Polito A, Pichuantes S, Yamada T, Morris C, Elgh F et al (1997) Rapid and specific detection of Sin Nombre virus antibodies in patients with hantavirus pulmonary syndrome by a strip immunoblot assay suitable for field diagnosis. J Clin Microbiol 35(3):600–608

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hooper JW, Custer DM, Smith J, Wahl-Jensen V (2006) Hantaan/Andes virus DNA vaccine elicits a broadly cross-reactive neutralizing antibody response in nonhuman primates. Virology 347(1):208–216

    CAS  PubMed  Google Scholar 

  • Hugot JP, Plyusnina A, Herbreteau V, Nemirov K, Laakkonen J, Lundkvist A, Supputthamongkol Y, Henttonen H, Plyusin A (2006) Genetic analysis of Thailand hantavirus in Bandicota indica trapped in Thailand. Virol J 3(72)

    Google Scholar 

  • Hutchinson K, Rollin P, Peters CJ (1998) Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg 59:58–65

    CAS  PubMed  Google Scholar 

  • ICTV (2013) Virus taxonomy: 2012 release. http://ictvonline.org/virusTaxonomy.asp. Accessed 6 Apr 2013

  • Jameson LJ, Taori SK, Atkinson B, Levick P, Featherstone CA, Van Der Burgt G, Mccarthy N, Hart J, Osborne JC, Walsh AL et al (2013) Pet rats as a source of hantavirus in England and Wales, 2013. Euro Surveill 18(9)

    Google Scholar 

  • Jannett FJ, Broschart MR, Grim LH, Schaberl JP (2007) Northerly range extensions of mammalian species in Minnesota. Am Midl Nat 158(1):168–176

    Google Scholar 

  • Jimenez JE, Feinsinger P, Jaksic FM (1992) Spatiotemporal patterns of an irruption and decline of small mammals in northcentral Chile. J Mammal 173:356–364

    Google Scholar 

  • Johnson AM, Bowen MD, Ksiazek TG, Williams RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST (1997) Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238(1):115–127

    CAS  PubMed  Google Scholar 

  • Johnson AM, De Souza LTM, Ferreira IB, Pereira LE, Ksiazek TG, Rollin PE, Peters CJ, Nichol ST (1999) Genetic investigation of novel hantaviruses causing fatal HPS in Brazil. J Med Virol 59:527–535

    CAS  PubMed  Google Scholar 

  • Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL, Daszak P (2008) Global trends in emerging infectious diseases. Nature 451(7181):990–993

    CAS  PubMed  Google Scholar 

  • Kallio ER, Klingstrom J, Gustafsson E, Manni T, Vaheri A, Henttonen H, Vapalahti O, Lundkvist A (2006) Prolonged survival of Puumala hantavirus outside the host: evidence for indirect transmission via the environment. J Gen Virol 87:2127–2134

    CAS  PubMed  Google Scholar 

  • Kallio ER, Voutilainen L, Vapalahti O, Vaheri A, Henttonen H, Koskela E, Mappes T (2007) Endemic hantavirus infection impairs the winter survival of its rodent host. Ecology 88(8):1911–1916

    PubMed  Google Scholar 

  • Kallio ER, Begon M, Henttonen H, Koskela E, Mappes T, Vaheri A, Vapalahti O (2009) Cyclic hantavirus epidemics in humans–predicted by rodent host dynamics. Epidemics 1(2):101–107

    PubMed  Google Scholar 

  • Kariwa H, Kimura M, Yoshizumi S, Arikawa J, Yoshimatsu K, Takashima I, Hashimoto N (1996) Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats. Arch Virol 141(12):2327–2338

    CAS  PubMed  Google Scholar 

  • Kilpatrick ED, Terajima M, Koster FT, Catalina MD, Cruz J, Ennis FA (2004) Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome. J Immunol 172(5):3297–3304

    CAS  PubMed  Google Scholar 

  • Klempa B (2009) Hantaviruses and climate change. Clin Microbiol Infect 15(6):518–523

    CAS  PubMed  Google Scholar 

  • Klempa B, Schmidt HA, Ulrich R, Kaluz S, Labuda M, Meisel H, Hjelle B, Kruger DH (2003) Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature. J Virol 77(1):804–809

    CAS  PubMed Central  PubMed  Google Scholar 

  • Klempa B, Stanko M, Labuda M, Ulrich R, Meisel H, Kruger DH (2005) Central European Dobrava hantavirus isolate from striped field mouse, Apodemus agrarius. J Clin Microbiol 43:2756–2763

    PubMed Central  PubMed  Google Scholar 

  • Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YV, Morozov VG, Okulova NM, Slyusareva GP, Smirnov A, Kruger DH (2008) Hemorrhagic fever with renal syndrome cause by 2 lineages of Dobrava hantavirus, Russia. Emerg Infect Dis 14(4):617–625

    PubMed Central  PubMed  Google Scholar 

  • Klempa B, Koivogui L, Sylla O, Koulemou K, Auste B, Kruger DH, Ter Meulen J (2010) Serological evidence of human hantavirus infections in Guinea, West Africa. J Infect Dis 201(7):1031–1034

    PubMed  Google Scholar 

  • Klempa B, Avsic-Zupanc T, Clement J, Dzagurova TK, Henttonen H, Heyman P, Jakab F, Kruger DH, Maes P, Papa A et al (2013) Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics. Arch Virol 158(3):521–529

    CAS  PubMed Central  PubMed  Google Scholar 

  • Koster FT, Jenison SA (1997) Hantaviruses. In: Gorbach SL, Bartlett JG, Blacklow NR (eds) Infectious diseases. Saunders, Philadelphia

    Google Scholar 

  • Kraus AA, Priemer C, Heider H, Kruger DH, Ulrich R (2005) Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities. Intervirology 48(4):255–261

    PubMed  Google Scholar 

  • Ksiazek T, Peters CJ, Rollin P, Zaki S, Nichol S, Spiropoulou C (1995) Identification of a new North American hantavirus that causes acute pulmonary insuffieiency. Am J Trop Med Hyg 52:117–123

    CAS  PubMed  Google Scholar 

  • Ksiazek TG, Nichol ST, Mills JN, Groves MG, Wozniak A, Mcadams S, Monroe MC, Johnson AM, Martin ML, Peters CJ et al (1997) Isolation, genetic diversity, and geographic distribution of Bayou virus (Bunyaviridae: Hantavirus). Am J Trop Med Hyg 57(4):445–448

    CAS  PubMed  Google Scholar 

  • Lederer S, Lattwein E, Hanke M, Sonnenberg K, Stoecker W, Lundkvist A, Vaheri A, Vapalahti O, Chan PK, Feldmann H et al (2013) Indirect immunofluorescence assay for the simultaneous detection of antibodies against clinically important old and new world hantaviruses. PLoS Negl Trop Dis 7(4):e2157

    PubMed Central  PubMed  Google Scholar 

  • Leduc JW (1987) Epidemiology of Hantaan and related viruses. Lab Anim Sci 37:413–418

    CAS  PubMed  Google Scholar 

  • Leduc JW, Smith GA, Childs JE, Pinheiro FP, Maiztegui JI, Niklasson B, Antoniades A, Robinson DM, Khin M, Shortridge KF (1986) Global survey of antibody to Hantaan-related viruses among peridomestic rodents. Bull World Health Organ 64:139–144

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lee HW, Lee PW, Tamura M, Tamura T, Oku-no Y (1979) Etiological relation between Korean hemorrhagic fever and epidemic hemorrhagic fever in Japan. Biken J 22:41–45

    CAS  PubMed  Google Scholar 

  • Lee HW, Lee PW, Johnson KM (1978b) Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 137:298–308

    CAS  PubMed  Google Scholar 

  • Lee HW, Bark DH, Baek LJ, Choi KS, Whang YN, Woo MS (1980) Korean hemorrhagic fever patients in urban areas of Seoul. Korean J Virol 10:1–6

    Google Scholar 

  • Lee HW, French GR, Lee PW, Baek LJ, Tsuchiya K, Foulke RS (1981a) Observations on natural and laboratory infection of rodents with the etiologic agent of Korean hemorrhagic fever. Am J Trop Med Hyg 30(2):477–482

    CAS  PubMed  Google Scholar 

  • Lee HW, Lee PW, Baek LJ, Song CK, Seong IW (1981b) Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg 30:1106–1112

    CAS  PubMed  Google Scholar 

  • Lee HW, Baek LJ, Johnson KM (1982) Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J Infect Dis 146:638–644

    CAS  PubMed  Google Scholar 

  • Lee HW, Ahn CN, Song JW, Baek LJ, Seo TJ, Park SC (1990) Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome. Arch Virol (Suppl 1):35–47

    Google Scholar 

  • Levis S, Morzunov SP, Rowe JE, Enría D, Pini N, Calderón GE, Sabattini M, Jeor SC (1998) Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis 177(3):529–538

    CAS  PubMed  Google Scholar 

  • Liang M, Li D, Xiao SY, Hang C, Rossi CA, Schmaljohn CS (1994) Antigenic and molecular characterization of hantavirus isolates from China. Virus Res 31:219–233

    CAS  PubMed  Google Scholar 

  • Lin XD, Wang W, Guo WP, Zhang XH, Xing JG, Chen SZ, Li MH, Chen Y, Xu J, Plyusnin A et al (2012) Cross-species transmission in the speciation of the currently known murinae-associated hantaviruses. J Virol 86(20):11171–11182

    CAS  PubMed Central  PubMed  Google Scholar 

  • Linderholm M, Sandstrom T, Rinnstrom O, Groth S, Blomberg A, Tarnvik A (1997) Impaired pulmonary function in patients with hemorrhagic fever with renal syndrome. Clin Infect Dis 25(5):1084–1089

    CAS  PubMed  Google Scholar 

  • Liu PQ, Liao HX, Fu JL, Hang CS, Song G (1984) Isolation of epidemic hemorrhagic fever virus from Rattus losea and Rattus confucianus and their antigenic identification. Bull Jiangxi Med Coll 3:1–7

    Google Scholar 

  • Lokugamage K, Kariwa H, Lokugamage N, Miyamoto H, Iwasa M, Hagiya T, Araki K, Tachi A, Mizutani T, Yoshimatsu K et al (2004) Genetic and antigenic characterization of the Amur virus associated with hemorrhagic fever with renal syndrome. Virus Res 101(2):127–134

    CAS  PubMed  Google Scholar 

  • Lopez N, Padula P, Rossi C, Lazaro ME, Franze-Fernandez MT (1996) Genetic identification of a new hantavirus causing severe pulmonary syndrome. Virology 220:223–226

    CAS  PubMed  Google Scholar 

  • Luis AD, Douglass RJ, Hudson PJ, Mills JN, Bjornstad ON (2012) Sin Nombre hantavirus decreases survival of male deer mice. Oecologia 169(2):431–439

    PubMed  Google Scholar 

  • Lundkvist A, Verner-Carlsson J, Plyusnina A, Forslund L, Feinstein R, Plyusnin A (2013) Pet rat harbouring Seoul hantavirus in Sweden. Euro Surveill 18(27):pii = 20521. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20521

  • Makela S, Mustonen J, La-Houhala I, Hurme M, Partanen J, Vapalahti O, Vaheri A, Pasternack A (2002) Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha(−308) G/A polymorphism. J Infect Dis 186(6):843–846

    CAS  PubMed  Google Scholar 

  • Makela S, Kokkonen L, La-Houhala I, Groundstroem K, Harmoinen A, Huhtala H, Hurme M, Paakkala A, Porsti I, Virtanen V et al (2009) More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings. Scand J Infect Dis 41(1):57–62

    CAS  PubMed  Google Scholar 

  • Martin ML, Lindsey Regnery H, Sasso DR, Mccormick JB, Palmer E (1985) Distinction between Bunyaviridae genera by surface structure and comparison with Hantaan virus using negative stain electron microscopy. Arch Virol 86:17–28

    CAS  PubMed  Google Scholar 

  • Matheus S, Djossou F, Moua D, Bourbigot AM, Hommel D, Lacoste V, Dussart P, Lavergne A (2010) Hantavirus pulmonary syndrome, French Guiana. Emerg Infect Dis 16(4):739–741

    PubMed Central  PubMed  Google Scholar 

  • Mertz GJ, Hjelle B, Crowley M, Iwamoto G, Tomicic V, Vial PA (2006) Diagnosis and treatment of new world hantavirus infections. Curr Opin Infect Dis 19(5):437–442

    PubMed  Google Scholar 

  • Mills JN (2005) Regulation of rodent-borne viruses in the natural host: implications for human disease. Arch Virol 19:45–57

    Google Scholar 

  • Mills JN (2006) Biodiversity loss and emerging infectious disease: an example from the rodent-borne hemorrhagic fevers. Biodiversity 7(1):9–17

    Google Scholar 

  • Mills JN, Ksiazek TG, Ellis BA, Rollin PE, Nichol ST, Yates TL, Gannon WL, Levy CE, Engelthaler DM, Davis T et al (1997) Patterns of association with host and habitat: antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. Am J Trop Med Hyg 56(3):273–284

    CAS  PubMed  Google Scholar 

  • Mills JN, Johnson JM, Ksiazek TG, Ellis BA, Rollin PE, Yates TL, Mann MO, Johnson RM, Campbell ML, Miyashiro J et al (1998) A survey of hantavirus antibody in small-mammal populations in selected U.S. National Parks. Am J Trop Med Hyg 58(4):525–532

    CAS  PubMed  Google Scholar 

  • Mills JN, Ksiazek TG, Peters CJ, Childs JE (1999) Long-term studies of hantavirus reservoir populations in the southwestern United States: a synthesis. Emerg Infect Dis 5(1):135–142

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mills JN, Ellis BA, Calderón G, Enría DA, Siazek TG (2007) A longitudinal study of hantavirus infection in three sympatric reservoir species in agroecosystems on the Argentina Pampa. Vector Born Zoon Dis 7:229–240

    Google Scholar 

  • Monroe MC, Morzunov SP, Johnson AM, Bowen MD, Artsob H, Yates T, Peters CJ, Rollin PE, Ksiazek TG, Nichol ST (1999) Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. Emerg Infect Dis 5(1):75–86

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mori M, Rothman AL, Kurane I, Montoya JM, Nolte KB, Norman JE, Waite DC, Koster FT, Ennis FA (1999) High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis 179(2):295–302

    CAS  PubMed  Google Scholar 

  • Moritz C, Patton JL, Conroy CJ, Parra JL, White GC, Beissinger SR (2008) Impact of a century of climate change on small-mammal communities in Yosemite National Park, USA. Science 322(5899):261–264

    CAS  PubMed  Google Scholar 

  • Muranyi W, Bahr U, Zeier M, Van Der Woude FJ (2005) Hantavirus infection. J Am Soc Nephrol 16(12):3669–3679

    CAS  PubMed  Google Scholar 

  • Mustonen J, Partanen J, Kanerva M, Pietila K, Vapalahti O, Pasternack A, Vaheri N (1996) Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int 49(1):217–221

    CAS  PubMed  Google Scholar 

  • Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs JE, Zaki S, Peters CJ (1993) Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262:914–917

    CAS  PubMed  Google Scholar 

  • Oktem IMA, Uyar Y, Dincer E, Gozalan A, Schlegel M, Babur C, Celebi B, Sozen M, Karatis A et al (2014) Dobrava-Belgrade virus in Apodemus flavicollis and A. uralensis mice, Turkey. Emerg Infect Dis 20:121–130

    PubMed Central  PubMed  Google Scholar 

  • Olsson GE, White N, Ahlm C, Elgh F, Verlemyr AC, Juto P, Palo RT (2002) Demographic factors associated with hantavirus infection in bank voles (Clethrionomys glareolus). Emerg Infect Dis 8(9):924–929

    PubMed Central  PubMed  Google Scholar 

  • Olsson GE, White N, Hjalten J, Ahlm C (2005) Habitat factors associated with bank voles (Clethrionomys glareolus) and concomitant hantavirus in northern Sweden. Vector Borne Zoonotic Dis 5(4):315–323

    PubMed  Google Scholar 

  • Olsson GE, Hjertqvist M, Lundkvist A, Hornfeldt B (2009) Predicting high risk for human hantavirus infections, Sweden. Emerg Infect Dis 15(1):104–106

    PubMed Central  PubMed  Google Scholar 

  • Olsson GE, Leirs H, Henttonen H (2010) Hantaviruses and their hosts in Europe: reservoirs here and there, but not everywhere? Vector Borne Zoon Dis 10(6):549–561

    Google Scholar 

  • Ostfeld RS, Keesing F (2000) The function of biodiversity in the ecology of vector-borne zoonotic diseases. Can J Zool 78(2061):2078

    Google Scholar 

  • Padula PJ, Edelstein A, Miguel SDL, Lopez NM, Rossi CM, Rabinovich RD (1998) Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241:323–330

    CAS  PubMed  Google Scholar 

  • Padula PJ, Rossi CM, La Valle MO, Martinez PV, Colavecchia SB, Edelstein A, Miguel SD, Rabinovich RD, Segura EL (2000) Development and evaluation of a solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein. J Med Microbiol 49(2):149–155

    CAS  PubMed  Google Scholar 

  • Padula P, La Valle MG, Alai MG, Cortada P, Villagra M, Gianella A (2002) Andes virus and first case report of Bermejo virus causing fatal pulmonary syndrome. Emerg Infect Dis 8(4):437–439

    PubMed Central  PubMed  Google Scholar 

  • Palma RE, Polop JJ, Owen RD, Mills JN (2012) Ecology of rodent-associated hantaviruses in the Southern Cone of South America: Argentina, Chile, Paraguay, and Uruguay. J Wildl Dis 48(2):267–281

    PubMed  Google Scholar 

  • Pattamadilok S, Lee BH, Kumperasart S, Yoshimatsu K, Okumura M, Nakamura I, Araki K, Khoprasert Y, Dangsupa P, Panlar P et al (2006) Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. Am J Trop Med Hyg 75(5):994–1002

    CAS  PubMed  Google Scholar 

  • Peters CM (1997) Sustainable use of biodiversity: myths, realities, and potential. In: Grifo F, Rosenthal J (eds) Biodiversity and human health. Island Press, Washington DC, pp 312–333

    Google Scholar 

  • Peters CJ, Simpson GL, Levy H (1999) Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Annu Rev Med 50:531–545

    CAS  PubMed  Google Scholar 

  • Plyusnin A (2002) Genetics of hantaviruses: implications to taxonomy. Arch Virol 147:665–682

    CAS  PubMed  Google Scholar 

  • Plyusnin A, Vapalahti O, Vasilenko V, Henttonen H, Vaheri A (1997) Dobrava virus in Estonia: does the virus exist throughout Europe? Lancet 349:1369–1370

    CAS  PubMed  Google Scholar 

  • Plyusnin A, Nemirov K, Apekina N, Plyusnina A, Lunkdvist Å, Vaheri A (1999) Dobrava hantavirus in Russia. Lancet 353:207

    CAS  PubMed  Google Scholar 

  • Plyusnin A, Vaheri A, Lundkvist A (2006) Saaremaa hantavirus should not be confused with its dangerous relative, Dobrava virus. J Clin Microbiol 44(4):1608–1611

    PubMed Central  PubMed  Google Scholar 

  • Plyusnin A, Ibrahim IN, Plyusnin A (2009) A newly recognized hantavirus in the Asian house rat (Rattus tanezumi) in Indonesia. J Gen Virol 90(Pt 1):205–209

    PubMed  Google Scholar 

  • Ramsden C, Holmes EC, Charleston MA (2009) Hantavirus evolution in relation to its rodent and insectivore hosts: no evidence for codivergence. Mol Biol Evol 26:143–153

    CAS  PubMed  Google Scholar 

  • Razzauti M, Plyusnina A, Sironen T, Henttonen H, Plyusnin A (2009) Analysis of Puumala hantavirus in a bank vole population in northern Finland: evidence for co-circulation of two genetic lineages and frequent reassortment between strains. J Gen Virol 90(Pt 8):1923–1931

    CAS  PubMed  Google Scholar 

  • Rivera PC, Ittig REG, Fraire HJR, Levis S, Gardenal CN (2007) Molecular identification and phylogenetic relationships among the species of the genus Oligoryzomys (Rodentia, Cricetidae) present in Argentina, putative reservoirs of hantaviruses. Zool Scr 36(3):231–239

    Google Scholar 

  • Rodriguez LL, Owens JH, Peters CJ, Nichol ST (1998) Genetic reassortment among viruses causing hantavirus pulmonary syndrome. Virology 242:99–106

    CAS  PubMed  Google Scholar 

  • Rollin PE, Ksiazek TG, Elliott LH, Ravkov EV, Martin ML, Morzunov S, Livingstone W, Monroe M, Glass G, Ruo S et al (1995) Isolation of Black Creek Canal virus, a new hantavirus from Sigmodon hispidus in Florida. J Med Virol 46(1):35–39

    CAS  PubMed  Google Scholar 

  • Root TL, Schneider SH (2002) Climate change: overview and implications for wildlife. In: Schneider SH, Root TL (eds) Wildlife responses to climate change. Island Press, Washington DC, pp 1–56

    Google Scholar 

  • Ruedas LA, Salazar-Bravo J, Tinnin DS, Armien B, Caceres L, Garcia A, Diaz MA, Gracia F, Suzan G, Peters CJ et al (2004) Community ecology of small mammal populations in Panama following an outbreak of hantavirus pulmonary syndrome. J Vector Ecol 29(1):177–191

    PubMed  Google Scholar 

  • Salazar-Bravo J, Armién B, Suzán G, Armién A, Ruedas L, Avila M, Zaldívar Y, Pascale JM, Gracia F, Yates TL (2004) Serosurveyof wild rodents for hantaviruses in Panama, 2000–2002. J Wildl Dis 40:103–109

    PubMed  Google Scholar 

  • Sauvage F, Langlais M, Pontier D (2007) Predicting the emergence of human hantavirus disease using a combination of viral dynamics and rodent demographic patterns. Epidemiol Infect 135(1):46–56

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schmaljohn CS, Dalrymple JM (1983) Analysis of Hantaan virus RNA: evidence for a new genus of Bunyaviridae. Virology 131:482–491

    CAS  PubMed  Google Scholar 

  • Schmaljohn C, Hjelle B (1997) Hantaviruses: a global disease problem. Emerg Infect Dis 3:97–103

    Google Scholar 

  • Schmaljohn CS, Hasty SE, Harrison SA, Dalrymple JM (1983) Characterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome. J Infect Dis 148:1005–1012

    CAS  PubMed  Google Scholar 

  • Schmaljohn CS, Hasty SE, Dalrymple JM, Leduc JW, Lee HW, Von Bonsdorff CH, Brummer-Korvenkontio M, Vaheri A, Tsai TF, Regnery HL et al (1985) Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. Science 227:1041–1044

    CAS  PubMed  Google Scholar 

  • Schmaljohn CS, Jennings GB, Hay J, Dalrymple JM (1986) Coding strategy of the S genome segment of Hantaan virus. Virology 155:633–643

    CAS  PubMed  Google Scholar 

  • Schmaljohn CS, Chu YK, Schmaljohn AL, Dalrymple JM (1990) Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants. J Virol 64:3162–3170

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schmaljohn C, Huggins J, Calisher CH (1998) Laboratory and field safety (Chapter XII) In: Lee HW, Calisher CH, Schmaljohn C (eds) Manual of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. WHO Collaborating Center for Virus Reference and Research, Asan Institute for Life Sciences, Seoul, Korea, pp 191–198

    Google Scholar 

  • Schountz T, Prescott J, Cogswell AC, Oko L, Mirowsky-Garcia K, Galvez AP, Hjelle B (2007) Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus. Proc Natl Acad Sci U S A 104(39):15496–15501

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schwarz AC, Ranft U, Piechotowski I, Childs JE, Brockmann SO (2009) Risk factors for human infection with Puumala virus, southwestern Germany. Emerg Infect Dis 15(7):1032–1039

    PubMed Central  PubMed  Google Scholar 

  • Sibold C, Meisel H, Lunkdvist Å, Cifire F, Ulrich R, Kozuch O, Labuda M, Kruger DH (1999) Simultaneous occurrence of Dobrava, Puumala, and Tula hantaviruses in Slovakia. Am J Trop Med Hyg 61:409–411

    CAS  PubMed  Google Scholar 

  • Sibold C, Ulrich R, Labuda M, Lundkvist Å, Schütt M, Gerke P, Leitmeyer K, Meisel H, Kruger DH (2001) Dobrava hantavirus causes hemorrhagic fever with renal syndrome in central Europe and is carried by two different Apodemus mice species. J Med Virol 63:158–167

    CAS  PubMed  Google Scholar 

  • Sirotin BZ, Keiser NP (2001) On the history of the study of haemorrhagic fever with renal syndrome in eastern Russia. Nephrol Dial Transplant 16(6):1288–1290

    CAS  PubMed  Google Scholar 

  • Sohn YM, Rho HO, Park MS, Kim JS, Summers PL (2001) Primary humoral immune responses to formalin inactivated hemorrhagic fever with renal syndrome vaccine (Hantavax): consideration of active immunization in South Korea. Yonsei Med J 42(3):278–284

    CAS  PubMed  Google Scholar 

  • Song G (1999) Epidemiological progresses of hemorrhagic fever with renal syndrome in China. Chin Med J 112(5):472–477

    CAS  PubMed  Google Scholar 

  • Song JW, Baek LJ, Nagle JW, Schlitter D, Yanagihara R (1996) Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States. Arch Virol 141(5):959–967

    CAS  PubMed  Google Scholar 

  • Song KJ, Baek LJ, Moon S, Ha SJ, Kim SH, Park KS, Klein TA, Sames W, Kim HC, Lee JS et al (2007) Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea. J Gen Virol 88(Pt 11):3121–3129

    CAS  PubMed Central  PubMed  Google Scholar 

  • Stocker TF, Qin D (2013) Climate change 2013: the physical science basis. In: Working Group I Contribution to the fifth assessment report of the intergovernmental panel on climate change: summary for policymakers. http://www.ipcc.ch/report/ar5/wg1/docs/WGIAR5_SPM_brochure_en.pdf

  • Suzan G, Marce E, Giermakowski JT, Mills JN, Ceballos G, Ostfeld RS, Armien B, Pascale JM, Yates TL (2009) Experimental evidence for reduced rodent diversity causing increased hantavirus prevalence. PLoS One 4(5):e5461

    PubMed Central  PubMed  Google Scholar 

  • Suzuki A, Bisordi I, Levis S, Garcia J, Pereira LE, Souza RP, Sugahara TKN, Pini N, Enría D, Souza LTM (2004) Identifying rodent hantavirus reservoirs. Brazil Emerg Infect Dis 10(12):2127–2134

    Google Scholar 

  • Taller AM, Xiao SY, Godec MS, Gligic A, Vsic-Zupanc T, Goldfarb LG, Asher DM (1993) Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice. J Infect Dis 168:750–753

    CAS  PubMed  Google Scholar 

  • Terajima M, Vapalahti O, Van Epps HL, Vaheri A, Ennis FA (2004) Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica. Microbes Infect 6(2):238–245

    CAS  PubMed  Google Scholar 

  • Terajima M, Hayasaka D, Maeda K, Ennis FA (2007) Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? Immunol Lett 113(2):117–120

    CAS  PubMed Central  PubMed  Google Scholar 

  • Tersago K, Verhagen R, Servais A, Heyman P, Ducoffre G, Leirs H (2009) Hantavirus disease (nephropathia epidemica) in Belgium: effects of tree seed production and climate. Epidemiol Infect 137(2):250–256

    CAS  PubMed  Google Scholar 

  • Tersago K, Crespin L, Verhagen R, Leirs H (2012) Impact of Puumala virus infection on maturation and survival in bank voles: a capture-mark-recapture analysis. J Wildl Dis 48(1):148–156

    PubMed  Google Scholar 

  • Toro J, Vega JD, Khan AS, Mills JN, Padula P, Terry W, Yadon Z, Valderrama R, Ellis BA, Pavletic C et al (1998) An outbreak of hantavirus pulmonary syndrome, Chile, 1997. Emerg Infect Dis 4(4):687–694

    CAS  PubMed Central  PubMed  Google Scholar 

  • Torres-Pérez F, Navarrete-Droguett J, Aldunate R, Yates TL, Mertz GJ, Vial PA, Ferres M, Marquet PA, Palma RE (2004) Peridomestic small mammals associated with confirmed cases of human hantavirus disease on southcentral Chile. Am J Trop Med Hyg 70:305–309

    PubMed  Google Scholar 

  • Torres-Pérez F, Palma RE, Hjelle B, Ferrés M, Cook JA (2010) Andes virus infections in the rodent reservoir and in humans vary across contrasting landscapes in Chile. Infect Genet Evol 10:820–825

    PubMed  Google Scholar 

  • Travassos Da Rosa ES, Mills JN, Padula PJ, Elkhoury MR, Ksiazek TG, Mendes WS, Santos ED, Aruojo GC, Martinez VP, Edelstein A (2005) Newly recognized hantaviruses associated with hantavirus pulmonary syndrome in northern Brazil: Partial genetic characterization of viruses and serologic implication of likely reservoirs. Vector-Borne Zoon Dis 5(1):11–19

    Google Scholar 

  • Travassos Da Rosa ES, Medeiros DB, Nunes MR, Simith DB, De Souza PA, Elkhoury MR, Lavocat M, Marques AA, Via AV, D’andrea P et al (2011) Pygmy rice rat as potential host of Castelo dos Sonhos Hantavirus. Emerg Infect Dis 17(8):1527–1530

    PubMed Central  PubMed  Google Scholar 

  • Umenai T, Lee PW, Toyoda T, Yoshinaga K, Horiuchi T, Lee HW, Saito T, Hongo M, Nobo-naga T, Ishida N (1979) Korean hemorrhagic fever in an animal laboratory. Lancet 1(8130):1314–1316

    CAS  PubMed  Google Scholar 

  • Vaheri A, Mills JN, Christina F, Spiropoulou F, Hjelle B (2011) Hantaviruses. In: Palmer SR, Soulsby L, Torgerson T, Brown DWG (eds) Oxford textbook of zoonoses. Oxford University Press, Oxford, pp 307–322 (Chap. 28 Fig. 28.2)

    Google Scholar 

  • Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T, Vapalahti O (2013) Hantavirus infections in Europe and their impact on public health. Rev Med Virol 23(1):35–49

    PubMed  Google Scholar 

  • Vapalahti O, Lundkvist A, Kukkonen SKJ, Cheng Y, Gilljam M, Kanerva M, Manni T, Pejcoch M, Niemimaa J, Kaikusalo A et al (1996) Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae. J Gen Virol 77(Pt 12):3063–3067

    CAS  PubMed  Google Scholar 

  • Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A (2003) Hantavirus infections in Europe. Lancet Infect Dis 3(10):653–661

    PubMed  Google Scholar 

  • Vincent MJ, Quiroz E, Gracias F, Sanchez A, Ksiazek T, Kitzutani P, Ruedas LA, Tinnin D, Caceres L, Garcia A et al (2000) Hantavirus pulmonary syndrome in Panama: identification of novel hantaviruses and their likely reservoirs. Virology 277:14–19

    CAS  PubMed  Google Scholar 

  • Wang H, Yoshimatsu K, Ebihara H, Ogino M, Araki K, Kariwa H, Wang Z, Luo Z, Li D, Hang C et al (2000) Genetic diversity of hantaviruses isolated in China and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus. Virology 278(2):332–345

    CAS  PubMed  Google Scholar 

  • Wilson DE, Reeder DM (2005) Mammal species of the world. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Wolfe ND, Daszak P, Kilpatrick AM, Burke DS (2005) Bushmeat hunting, deforestation, and prediction of zoonoses emergence. Emerg Infect Dis 11:1822–1827

    PubMed Central  Google Scholar 

  • Wright HE, Kutzbach JE, Webb T, Ruddiman WE, Street-Perrott FA, Bartlein PJ (1993) Global climates since the last glacial maximum. University of Minnesota Press, Minneapolis

    Google Scholar 

  • Xiao SY, Diglisic G, Vsic-Zupanc T, Leduc JW (1993) Dobrava virus as a new Hantavirus: evidenced by comparative sequence analysis. J Med Virol 39:152–155

    CAS  PubMed  Google Scholar 

  • Xu ZY, Gou CS, Wu YL, Zhang XW, Liu K (1985) Epidemiological studies of hemorrhagic fever with renal syndrome: analysis of risk factors and of transmission. J Infect Dis 152:137–144

    CAS  PubMed  Google Scholar 

  • Yan L, Fang LQ, Huang HG, Zhang LQ, Feng D, Zhao WJ, Zhang WY, Li XW, Cao WC (2007) Landscape elements and Hantaan virus-related hemorrhagic fever with renal syndrome, People’s Republic of China. Emerg Infect Dis 13(9):1301–1306

    PubMed Central  PubMed  Google Scholar 

  • Yashina LN, Patrushev NA, Ivanov LI, Slonova RA, Mishin VP, Kompanez GG, Zdanovskaya NI, Kuzina II, Safronov PF, Chizhikov VE et al (2000) Genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of Russia. Virus Res 70(1–2):31–44

    CAS  PubMed  Google Scholar 

  • Yates TL, Mills JN, Parmenter CA, Ksiazek TG, Parmenter RR, Vande Castle JR, Calisher CH, Nichol ST, Abbott KD, Young JC et al (2002) The ecology and evolutionary history of an emergent disease: hantavirus pulmonary syndrome. Bioscience 52(11):989–998

    Google Scholar 

  • Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, Feddersen RM, Zumwalt RE, Miller GL, Khan AS et al (1995) Hantavirus pulmonary syndrome: pathogenesis of an emerging infectious disease. Am J Pathol 146:552–579

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zhang YZ, Zou Y, Yao LS, Hu GW, Du ZS, Jin LZ, Liu YY, Wang HX, Chen X, Chen HX et al (2007) Isolation and characterization of hantavirus carried by Apodemus peninsulae in Jilin, China. J Gen Virol 88(Pt 4):1295–1301

    CAS  PubMed  Google Scholar 

  • Zhang YZ, Zou Y, Fu ZF, Plyusnin A (2010) Hantavirus infections in humans and animals, China. Emerg Infect Dis 16(8):1195–1203

    PubMed Central  PubMed  Google Scholar 

  • Zou Y, Hu J, Wang ZX, Wang DM, Yu C, Zhou JZ, Fu ZF, Zhang YZ (2008) Genetic characterization of hantaviruses isolated from Guizhou, China: evidence for spillover and reassortment in nature. J Med Virol 80(6):1033–1041

    PubMed  Google Scholar 

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Yuill, T.M., Mills, J.N. (2014). Hantaviruses. In: Yamada, A., Kahn, L., Kaplan, B., Monath, T., Woodall, J., Conti, L. (eds) Confronting Emerging Zoonoses. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55120-1_4

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