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Interaction Between RGC Bodies and Glia

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Neuroprotection and Neuroregeneration for Retinal Diseases

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Abstract

The interactions between glial cells and retinal ganglion cells (RGC) in glaucoma are complicated and are variable depending on the cell types and the status of cell activity. Structural stability is only one function of glial cells. Other important roles of glial cells include intertalking with neurons, other glial cells, and extracellular matrix through direct or indirect communication methods. The transition from quiescent status to reactive status drastically changes the activity and characteristics of glial cells in glaucoma. Glial cells exert both neuroprotective and neurotoxic effects on RGC and effect not only cell survival but also cell morphology, synapse connectivity, and cell functions. Investigations into glial cell modulation and their roles in glaucoma could provide new strategies for glaucoma therapy that could complement intraocular pressure reduction therapy. These new strategies could rescue RGC from death, promote optic nerve regeneration, preserve dendritic morphology and synaptic connectivity, and inhibit the pathological reformation of extracellular matrix in the optic nerve.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Yamanashi, 1110 Shimokato Chuo, Yamanashi, 409-3898, Japan

    Kenji Kashiwagi

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  1. Kenji Kashiwagi
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Correspondence to Kenji Kashiwagi .

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Editors and Affiliations

  1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Toru Nakazawa

  2. Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan

    Yasushi Kitaoka

  3. Visual Research Project, Tokyo Metropolitan Inst of Med Sci, Tokyo, Japan

    Takayuki Harada

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Kashiwagi, K. (2014). Interaction Between RGC Bodies and Glia. In: Nakazawa, T., Kitaoka, Y., Harada, T. (eds) Neuroprotection and Neuroregeneration for Retinal Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54965-9_11

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  • DOI: https://doi.org/10.1007/978-4-431-54965-9_11

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