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Thymic Stromal Lymphopoietin (TSLP)

TSLP in Allergy, Autoimmunity, and Cancer

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Cytokine Frontiers

Abstract

Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells (DCs), basophils, eosinophils, mast cells, CD4+, CD8+, and natural killer (NK) T cells, B cells, and epithelial cells. Although the role of TSLP in the promotion of TH2 responses has been extensively studied in the context of lung- and skin-specific allergic disorders, it is becoming increasingly clear that TSLP may impact multiple disease states within multiple organ systems, including the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity. This review will highlight recent advances in the understanding of TSLP signal transduction, as well as the role of TSLP in allergy, autoimmunity, and cancer. Importantly, these insights into TSLP’s multifaceted roles could potentially allow for novel therapeutic manipulations of these disorders.

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Abbreviations

AD:

Atopic dermatitis

AR:

Allergic rhinitis

BAL:

Bronchoalveolar lavage

COPD:

Chronic obstructive pulmonary disease

DC:

Dendritic cell

FITC:

Fluorescein isothiocyante

JAK:

Janus kinase

LC:

Langerhans cell

Nod2:

Nucleotide-binding oligomerization domain-containing protein 2

SPINK5:

Serine protease inhibitior Kazal-type 5

STAT:

Signal transducers and activators of transcription

TSLP:

Thymic stromal lymphopoietin

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Acknowledgments

Support was provided by the Crohn’s and Colitis Foundation of America (F.R.) and NIH grants 5T32AI007411-19 (B.D.B. and T.A.S.) and AI068731, AR056113, 5AR055695, HL098067, HL102708, AR059058 (S.F.Z.).

Conflict of Interest Statement 

The authors have no conflicts of interest concerning the work in this review.

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Authors and Affiliations

  1. Immunology Program, Benaroya Research Institute, Seattle, WA, 98191, USA

    Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima & Hongwei Han

  2. Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA

    Steven F. Ziegler & Florence Roan

  3. Benaroya Research Institute, 1201 9th Avenue, Seattle, WA, 98101, USA

    Steven F. Ziegler

  4. Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA, USA

    Florence Roan

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Correspondence to Steven F. Ziegler .

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  1. Department of Immunoregulation Institute of Medical Science, Tokyo Medical University, Tokyo, Tokyo, Japan

    Takayuki Yoshimoto

  2. Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

    Tomohiro Yoshimoto

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Ziegler, S.F., Roan, F., Bell, B.D., Stoklasek, T.A., Kitajima, M., Han, H. (2014). Thymic Stromal Lymphopoietin (TSLP). In: Yoshimoto, T., Yoshimoto, T. (eds) Cytokine Frontiers. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54442-5_12

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