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Smart Bioconjugates

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Smart Biomaterials

Part of the book series: NIMS Monographs ((NIMSM))

Abstract

Bioconjugations with synthetic polymers have been a versatile way to add new value, advanced features and unique properties to biomolecules. Smart polymer-protein conjugates have been investigated over the past 30 years. Since the conjugation of smart polymer to single molecule can generate a nano-scale switch, many researchers have conjugated smart polymers to proteins for a great variety of applications in affinity separations, enzyme bioprocesses, drug delivery, diagnostics and biosensors, cell culture processes including tissue engineering, and DNA motors. Biomolecules that can be conjugated with smart polymers include not only proteins but also peptides, polysaccharides, and DNA, and lipids etc. This chapter reviews different types of smart polymer-biomolecule conjugates that have been developed in the last decades.

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Authors and Affiliations

  1. National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan

    Mitsuhiro Ebara, Yohei Kotsuchibashi, Koichiro Uto & Takao Aoyagi

  2. The University of Tokyo, Tokyo, Japan

    Young-Jin Kim

  3. University of Alberta, Edmonton, AB, T6G 2V4, Canada

    Ravin Narain

  4. Waseda University, 2-8-26 Nishiwaseda, Shinjuku-ku, Tokyo, 169-0051, Japan

    Naokazu Idota

  5. Stratos Genomics, World Trade Center North, 5th Floor, 2401 Elliott Avenue, Seattle, WA, 98121, USA

    John M. Hoffman

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  1. Mitsuhiro Ebara
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  3. Koichiro Uto
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Correspondence to Mitsuhiro Ebara or John M. Hoffman .

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© 2014 National Institute for Materials Science, Japan. Published by Springer Japan

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Ebara, M. et al. (2014). Smart Bioconjugates. In: Smart Biomaterials. NIMS Monographs. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54400-5_6

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