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First and Second Heart Field

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Congenital Heart Diseases: The Broken Heart

Abstract

The heart forms from the first and second heart fields which contribute to distinct regions of the myocardium. This is supported by clonal analyses which identify corresponding first and second cardiac cell lineages in the heart. Progenitor cells of the second heart field and its subdomains are controlled by a gene regulatory network and by signalling pathways which determine their behaviour. Multipotent cells in this field also can contribute cardiac endothelial and smooth muscle cells. Furthermore skeletal muscles of the head and neck are related clonally to myocardial cells that form the arterial and venous poles of the heart. These lineage relationships, together with the genes that regulate the heart fields, have major implications for congenital heart disease.

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Acknowledgements

MB acknowledges support from the Pasteur Institute and the CNRS (URA 2578). She thanks Robert G. Kelly for comments on the text.

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Authors and Affiliations

  1. Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France

    Margaret Buckingham

Authors
  1. Margaret Buckingham
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Correspondence to Margaret Buckingham .

Editor information

Editors and Affiliations

  1. Cardiovascular Genetics, Charité - Universitätsmedizin Berlin , Berlin, Germany

    Silke Rickert-Sperling

  2. Developmental Biology, Inst. of Marseilles, Aix-Marseille Univ. , Marseille, France

    Robert G. Kelly

  3. Dpt. of Pediatrics Div.of Pediatric Card, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

    David J. Driscoll

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Buckingham, M. (2016). First and Second Heart Field. In: Rickert-Sperling, S., Kelly, R., Driscoll, D. (eds) Congenital Heart Diseases: The Broken Heart. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1883-2_3

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